Biotranex

Biotranex is an innovative biotechnology service company located in New Jersey, USA, primarily providing a wide range of drug metabolism and pharmacokinetic studies for pharmaceutical and biotechnology companies. It offers various services to study the transport properties of new chemical entities to meet FDA and EMA guidelines, such as unidirectional or bidirectional permeability assays in CACO-2, MDCK, and P-gp- and BCRP-transfected cell lines; transporter phenotyping/inhibition (IC50 or Ki), and hepatic uptake in human hepatocytes and preclinical species. Biotranex has also developed proprietary technologies, such as BSEPcyte® and MDR3cyte®, to understand the roles of bile salt export pump (BSEP) and multidrug resistance protein 3 (MDR3) in drug-induced liver injury (DILI).