Topos Bio

Topos Bio is an AI-based biotechnology company dedicated to developing therapies targeting Intrinsically Disordered Proteins (IDPs). Headquartered in San Francisco, the company’s platform combines physics with generative artificial intelligence to target proteins involved in neurodegenerative diseases, oncology, and metabolic disorders. The company’s models can generate large-scale ensemble models to capture the dynamic behavior of proteins, identify transient binding opportunities within these ever-changing structures, and apply generative chemistry approaches to design small molecules capable of modulating disordered regions, thereby helping individuals find treatments for their conditions.