Advanced Bifurcation Systems Secures $20.8 Million Oversubscribed Financing and Files Preliminary IPO Prospectus

Jan 21, 2025 22:15 CST Updated 22:15

Advanced Bifurcation Systems

Medical Device Developer

Advanced Bifurcation Systems（ABS）Announced the completion of a new round of $20.8 million in oversubscribed financing. The company also expanded its board of directors,Advanced Bifurcation Systems（ABS）Malia Chui from the largest investment firm, Brandon Holdings, and Susan Yashar, Deputy Global CEO and Global General Counsel of Deloitte, join the board.

Executive Evaluation

"We are honored to have received strong support from investors in this oversubscribed financing round. Many of them are industry experts who recognize the transformative potential of our technology. We are equally pleased to welcome Malia Chui and Susan Yashar to our board of directors. Their expertise, along with the guidance of Willie Lawrence, M.D., as a new member of our Scientific Advisory Board and advisor to our CEO, will help us prepare for FDA and other regulatory approvals as we work towards the commercialization of the ABS device."

---Mehran Khorsandi CEO of ABS, M.D.

Coronary artery bifurcation lesions refer to severe stenosis occurring either separately or simultaneously in the main coronary artery and its branches, mainly including the left anterior descending artery, diagonal branch, circumflex artery, obtuse marginal branch, distal bifurcation of the right coronary artery, and left main bifurcation lesions. These account for 15%-20% of all percutaneous coronary interventions and represent a challenge in coronary interventional treatment.

Currently, there are two main categories for the treatment of coronary artery bifurcation disease:

Single-stent technique, which involves implanting a stent only in the main branch while protecting the side branch with a guidewire or dilating it with a balloon. This includes the dual-balloon kissing technique, where balloons in both the main vessel and the side branch are expanded simultaneously to prevent plaque shift towards the side branch, which carries a risk of branch occlusion.
The double-stent technique, which involves implanting stents in both the main branch and larger side branches. This includes: T-stenting, crush technique, culotte technique, stent kissing technique, V-stenting, and Y-stenting. There is no risk of branch occlusion, but the technical difficulty is high, and determining the strategy in advance is crucial.

These two categories can partially solve the problem.CrownReopening of coronary artery bifurcation lesions, but there are still many problems. Restenosis is a major issue.The restenosis rate of coronary artery bifurcation lesions is significantly higher than other coronary artery lesions. The main reasons are:

The stent was not properly apposed to the vessel wall at the ostium of the bifurcation lesion and failed to fully cover the ostium.
Plaque "snowplow effect" or ridge displacement in collateral vessels leads to their occlusion or significant stenosis.
Metal overlap at the bifurcation site, slow endothelial coverage, and susceptibility to late thrombotic events.

In fact, causingTreatment of coronary artery bifurcation lesions is challenging, with many adverse events after stent implantation, primarily due to the lack of truly matching solutions.Stents for Coronary Bifurcation Lesions. It requires doctors to continuously develop various surgical techniques, but due to the lack of good tools, even though doctors keep optimizing treatment methods, they still cannot solve the problems of difficulty and multiple complications.

AndAdvanced Bifurcation SystemsDevelopment of a Coronary Stent with Side Branches---ABS, which is expected to solve the existing problems of PCI surgery.ABS was granted the "Breakthrough Device" designation by the FDA in 2023.

ABS

ABSIt is a modular, dual-catheter, independently movable stent system. ABS is developed byMother-Child Stent (MDS)Balloon CatheterAndDaughter Stent (DS)Balloon CatheterComposition.Daughter Stent (DS)Balloon Catheter LoadInMother-Child Stent (MDS)Balloon CatheterTheOn the sleeve, and throughOverMother-Child Stent (MD)ChinaThe opening between。

Among themSide-Branch Stent (DS)Balloon catheters can be divided into two types: with stent and without stent, according to the lesion requirements.

Without StentDaughter Stent (DS)Balloon Catheter

InABSTheIn the case of bifurcation stent components,Side-Stent (DS)Balloon CatheterThe length of the delivery balloon is mounted on the distal half of the balloon.Daughter Stent (DS)Twice as much.

With stentDaughter Stent (DS)Balloon Catheter

ABSMultiple clinical trials have been completed, and the following is one of the case images:

Circle in the pictureA is the proximal narrowing or stenosis,CircleCircle B is a bifurcation lesion

The figure belowThe occluded vessel is shown, and the vessel is shown to have good blood flow recovery after implantation. The ABS was deployed in about 5 minutes and passed directly through another stent without pre-dilation before deployment.

ABS Demo

Belt Stand

WithoutSub-stent

Advanced Bifurcation Systems

Advanced Bifurcation Systems Advanced Bifurcation Systems Inc. is a clinical-stage innovative medical device company developing a novel stent platform for the simplified treatment of all bifurcation lesions in coronary angioplasty.