Multiple First-in-Class Biologics Unveiled at AACR 2025 by AstraZeneca, GSK, Innovent and Others

The 2025 AACR is in full swing. At this conference, nearly 50 FIC biologics are making their debut. What exactly are they? Let's take a look together. Also, there's a complete list at the end of the video, so be sure to save it.

First, let's talk about MNC,AstraZenecaA brand-new product was unveiled for the first time at the conference.Prostate Cancer TCE Therapy（AZD6621）Preclinical study data. This product enhances the therapeutic index in three ways, including targeting new pathways.（STEAP2）, optimize the affinity of the CD3 binding domain, and integrate the CD8 binding domain. It is said that the first human clinical trial of this product will be launched this year.

GSK and Merck also不甘示弱, each bringing a FIC new drug.GSKIt is a phosphate channel protein.（XPR1）Inhibitor, mainly used for OC(Ovarian Cancer)and UC(Uterine Cancer)。MerckIt is a tri-specific antibody.（MUC1/TRAILR1/TRAILR1). This product has been developed for cancer treatment and also has the potential to be used in combination with chemotherapy and ADC, showing great promise.

Let's take a look at the performance of pharmaceutical companies in China. Innovent Bio announced the most, releasing four FIC new drugs at once, including bispecific antibodies.（MUC16 TCE）, Triple Antibody（IBI3019，CDH17/EGFR/FCGR3A）, there are also bispecific ADCs（IBI3022，B7-H4/TROP2）And antibody fusion protein(PD1-IFNα Fusion Protein), with a particularly rich variety of drug types.

In addition, about a dozen pharmaceutical companies, including Dongyangguang, Philochem, Fluoropharm, Qide, Orange Sail, and Tagray, also showcased their FIC new drugs at the conference. The indications for these drugs are mostly focused onOncology FieldAmong them, ADCs, bispecific antibodies, and trispecific antibodies are the most common, while others include PDCs, antibody-conjugated degraders, radiopharmaceuticals, and more.

Finally, friends who want the 2025 AACR conference's first-release FIC new drug list, remember to take a screenshot and save it.