Tingsn Medical Completes Nearly RMB 100 Million Series B+ Financing to Advance 4D ICE Development

The financing funds will be mainly used for4DIntracardiac Ultrasound (4D ICE）The research and development of products, clinical advancement, and preparation for mass production further consolidate TINGSN's leading advantage in the high-end cardiovascular imaging sector.

It is worth noting that TINGSN Technology this year4Month29Successfully Completed on [Date]China's First Case4D ICEClinical Research in Humans, marking a new phase where China enters the "parallel running" stage internationally in the field of cardiovascular interventional imaging. This major technological breakthrough also verifies TINGSN'sFrom2D ICETo4D ICEThe full-chain independent innovation capabilityHas become increasingly mature. 

▲Image SourceTINGSN TechnologyOfficial WeChat

# The First Case in China4D ICEClinical Research in Humans

2025Year4Month29Day, byProfessor Kong Xiangqing from Jiangsu Provincial People's HospitalLed by Professor Sun Wei and Professor Zhang Haifeng in collaborationTINGSN 4D ICEFirst Clinical StudyAchieved complete success.

The patient is76-Year-Old Female,7Diagnosed with atrial fibrillation and underwent ablation surgery before the year, followed by recurrent palpitations,10Days ago, the patient had a recurrence accompanied by nausea and vomiting. The patient has a history of hypertension. Preoperative transesophageal echocardiography indicated slow blood flow in the left atrium and left atrial appendage, showing "spontaneous echo contrast," with reduced emptying velocity of the left atrial appendage blood flow.22cm/sAfter comprehensive evaluation by the medical team and full communication with the patient and family about the treatment plan, it was decided to perform a "one-stop" atrial fibrillation radiofrequency ablation combined with left atrial appendage occlusion interventional surgery.

During the operation after puncture, the operator proceeds.TINGSN 4D ICEThe catheter enters the right heart through the femoral vein approach, and then observes the structure of each chamber and the condition of the valves.4D ICEUnder guidance, complete the atrial septal puncture and observe the preoperative pericardium. After establishing access, perform pulmonary vein isolation first, then observe the left atrial appendage under real-time dynamic 3D ultrasound imaging, guide the occlusion device into position, and complete the occlusion. After completing the intervention, withdraw the delivery system and confirm the integrity of the pericardium through 2D and 3D images. The patient's vital signs were stable post-operation and transferred to the ward. Compared with traditional methods...XFluoroscopy,ICETechnology reduces radiation exposure timeShorten62%, Total operation timeReduced by approximately30Minute。

"The reconstructed 3D real-time intracardiac images are accurately matched with the 2D intracardiac ultrasound images, and synchronized implementation is achieved.360°Panoramic observation."Professor Xiangqing Kong particularly pointed out,"This multi-dimensional information integration capability is of great value in reducing the incidence of complications and improving the efficiency of surgical ablation."The clinical team feedback indicates that the imaging quality of this device in critical aspects such as valve regurgitation assessment and atrial appendage lobulation measurement has reached the level of mainstream international products.

TINGSN General Manager Wang Jing revealed that the smooth progress of this clinical research stems from"Ten Years to Sharpen a Sword"Technical沉淀: FromASICFrom the underlying architecture design of the chip to its implementation1mmAdaptive imaging algorithm for axial resolution, the R&D team has made a breakthroughControl the size of the ultrasound probe2mmDiameter, while maintaining high frame rate imaging capabilities.

# AboutTINGSN 4D ICESystem (Under Development)

TINGSN 4D ICEThe system integratesASICElectronic Matrix Transducer Technology and High-Speed Volumetric Reconstruction Algorithm Achieve Imaging Breakthrough in Cardiac Interventional Diagnosis and Treatment, Constructing High-Resolution Dynamic 3D Heart Models with the Following Revolutionary Advantages in Complex Surgeries:

● Intelligent Measurement and Precision Navigation:Integrated real-time 3D spatial coordinate system supports millimeter-level dimensional measurement of devices such as occluders and ablation catheters during surgery, reducing the complexity of operations like left atrial appendage closure.83%Preoperative imaging dependence. Through multi-planar reconstruction technology, the anatomical structure of the fossa ovalis and the ablation path can be observed simultaneously, achieving puncture point localization error during interatrial septal puncture.<2mmClinical Breakthrough.

● Dynamic Visualization of Surgical Process Optimization:Real-time 3D imaging can more intuitively display the surgical process, optimize the transseptal puncture procedure, clearly show the contact between the ablation catheter tip and the pulmonary vein, define the morphology of the left atrial appendage and the positional relationship between the surgical instruments and the left atrial appendage during left atrial appendage closure, assist the operator in quickly locating the operation, shorten operation time, reduce complications, and thereby lower surgical risks.

● Low Radiation and Convenient Operation System:Paired with a cart-type color Doppler ultrasound diagnostic instrument, it features an ergonomic design and a minimalist operation interface, significantly reducing the workload for both doctors and patients.X Radiation Exposure, Optimize Clinical Workflow.

# Executive Evaluation

TINGSN TechnologyCEOZhang DongyuIndicates:“4D ICERepresents the pinnacle of cardiovascular interventional imaging technology, the team can4The successful completion of the product's development and the smooth execution of the first human clinical trial within the year are attributed to TINGSN's solid foundational technology accumulation, sufficient R&D investment, and outstanding, highly efficient team execution.4D ICEThe successful development has injected strong momentum into the company's future growth, which will significantly enhance the company's competitiveness in the global market, marking a major step forward for the team in achieving‘Become an influential medical device brand made in China’has taken a solid step towards the vision.”

Managing Director of Efung CapitalFan RongkuiIndicates:“Intracardiac Interventional Ultrasound (ICE) as various cardiac electrophysiological and structural heart interventional procedures‘Eyes’, which has been continuously gaining clinical recognition. The product has high overall technical barriers and is currently on the eve of replacing Chinese production. The TINGSN team possesses strong medical-engineering integration and innovation capabilities, deep technical accumulation and engineering transformation abilities, as well as rich commercialization experience and execution power. The core product2D ICEThe first product in China to obtain certification through the medical device green channel, achieving rapid and significant commercial success,4D ICEPioneering the completion of the first human study and achieving significant breakthroughs in the autonomous development of core component supply chains, which is expected to maximize its cost and differentiation advantages in future competition.”

Director of Star Bridge CapitalGuo KaiIndicates:“TINGSN, as a leading enterprise in intracardiac ultrasound in China, from2D ICETo4D ICE, from the first domestically produced transducer自主研发与生产 to completionASICChip tape-out,7Completed several during the year‘Zero Breakthrough’, achieving true China-made substitution and technology leadership amid the rapid growth of China's electrophysiology-related fields. We believe TINGSN will continue to shine on an even broader stage!”

# ICEMarket Prospects and Overview

Intracardiac Ultrasound (ICE) is aIntegration of Phased Array Ultrasound Imaging and Cardiac Catheterization in Percutaneous Vascular Interventional Ultrasound Technology。

ICE HasReal-time Ultrasound Imaging、Not limited by the imaging windowAndGood ToleranceAdvantages such as these. During the surgical procedure, only local anesthesia is required, with flexible bending adjustments, and real-time ultrasound imaging visibility throughout. This helps clinicians obtain anatomical structures within the heart chambers, monitor intraoperative complications in real time, and perform Doppler blood flow assessments.

In recent years, with the rapid development of interventional diagnosis and treatment technologies for structural heart disease and arrhythmia, the requirements for intraoperative imaging have been increasing. ICE The scope of application of the technology is becoming wider and wider,ICE Catheters are gradually becoming a key tool for interventional cardiologists.“Golden Eye”。

2021Year, GlobalICEThe market size has reached8135Million USD, Expected2028will reach by the year1.3Billion US dollars, Compound Annual Growth Rate (CAGR) for6.61%。

From a regional perspective, the Chinese market has changed rapidly in the past few years.2021Annual market size is443Million US dollars, accounting for approximately global5.45%。Expected2028Will reach by the year769Million USD, at which time the global share will reach5.89%。

▲GlobalICEMarket Size, DataOriginated fromGlobaI Info Research

According to the "2025-2029Annual Intracardiac Ultrasound (ICE) Catheter Industry In-Depth Market Research and Investment Strategy Recommendation Report" shows that, globally,ICEThe catheter market has attracted Siemens, Johnson & Johnson, Philips,GEThe layout of well-known international companies such as medical, Boston Scientific, and Abbott has led to intense market competition. Foreign companies started their research and development earlier, in3D ICECatheter and New Generation4D ICELeading in catheter technology.

ExceptTINGSN TechnologyExternal,ChinaICECatheter Market Layout EnterprisesAlsoIncluding Suzhou Bingjing Intelligent Medical Technology Co., Ltd., Shenzhen Xinhuantech Co., Ltd., and Shenzhen Saihe Medical Technology Co., Ltd., etc.

Among them, TINGSN independently developedTINGSN Sonic Eyes 10In2023Year11Month28Approved for marketing in Japan, becomingChina's First Domestically Produced Intracardiac Ultrasound Diagnostic Catheter。

Due to4D ICEWith extremely high technical barriers，Due to technical limitations,ICE products from Chinese manufacturers are mostly in the research and development and clinical stages, and with2D ProductionProduct-oriented,4D ICEThe market is still in its infancy, with only a few manufacturers truly making strategic moves.

Currently, there are mainly 3 imported products in China (includingJohnson & Johnson、Abbott、Siemens) and 4 domestically produced (includingTINGSN Technology、Heart寰 Technology、Crystal Ice Technology、Saihe Medical）ICE Product Approved。

TINGSN Technology——China's First Self-Developed ICE Catheter

AsThe First Domestically Produced Product Approved in China(In November 2023) intracardiac echocardiography diagnostic catheter,TINGSN TechnologyTINGSN Sonic Eyes 10 consists of a catheter body, an operating handle, and a connector. It is used in conjunction with the company's portable color ultrasound diagnostic system and is suitable for medical institutions to perform ultrasound imaging of the heart, major cardiac vessels, and intracardiac anatomical structures.

Heart寰 Technology currently has 2D and 4D ICE products,Among which2D ICE System Has the World's Thinnest Ultrasound Catheter Size, approaching the industry's technological limit, will help minimize complications caused by puncture injuries and provide patients with a high-quality ICE solution made in China.

▲4D ICE Catheter

4D ICE SystemIntegrated with multiple cutting-edge technologies in current ultrasound imaging, such as soft beamforming and arbitrary waveform transmission.，Supports dynamic 3D display of cardiac structures and 2D imaging of arbitrary sections, with flexible and convenient operation (bending radius ≥120°), a broad imaging field of view (≥90°x 90°), and high 4D frame rate, ensuring efficiency and precision during interventional procedures.Effectively reduce the risk of cardiac interventional surgery and shorten the learning curve for operators.ThisThe system has completed clinical enrollment.In animal experiments, the three-dimensional structures such as the four-chamber heart, atrium, ventricle, and valves are clearly and dynamically visible in real-time, achieving excellent imaging results.

Portable Ultrasound Diagnostic DeviceComposed of an ultrasound host, connector, and power adapter.Single-Use Intracardiac Ultrasound Imaging CatheterComposed of the catheter tip, adjustable bend tube, operation handle, and tail connector.UtilizeInverse Piezoelectric EffectConvert the pulse electrical signal output by the portable ultrasound diagnostic device into ultrasound waves and emit them into the cardiac cavity tissue., and receive the echo signal transmitted to the portable ultrasound diagnostic instrument, which is then converted into a digital image signal and displayed on the monitor.

The above two products are used together for ultrasonic imaging of the adult heart, major cardiac vessels, and intracardiac anatomical structures.Compared with similar products, it has a largerDetection depth, and the first intracardiac ultrasound imaging system in China。

# AboutTINGSN Technology

TINGSN TechnologyFounded in2017Year,Headquartered in Nanjing, China, with R&D centers in both China and the United States.，focusing on the field of cardiac electrophysiology and structural heart disease.

CompanyFounded by senior scientists in the ultrasound field, cardiologists, and serial entrepreneurs, and supported by the National Key Project.AThis type of talent (overseas returnee Ph.D.) has led the establishment of an international R&D team and is deeply collaborating with globally renowned clinical teams and top acoustic research institutions in China.

TINGSN TechnologyIn2024YearObtain“Jiangsu Potential Unicorn Enterprise”Focusing on technological innovation in cardiac electrophysiology and structural heart disease, through the combined application of imaging, mapping, and ablation energy, it aims to provide more effective treatment for a greater number of patients with heart disease.

Welcome companies to actively participate in the conference organized by SIYU ↓

July 17, 2025, The 2nd Global Medical Technology Conference

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