On July 8, the Chinese Drug Clinical Trial Registration and Information Disclosure Platform showed that AstraZenecaRegistered oneResearch on AZD5492 inSystemic Lupus Erythematosus or Idiopathic Inflammatory MyopathyStudy on the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics in Adult Subjects.Screenshot source:Drug Clinical Trial Registry and Information Disclosure PlatformThis is aOpen-label, Phase I Study, Aimed atEvaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of AZD5492 in adult subjects with systemic lupus erythematosus or idiopathic inflammatory myopathy following single ascending dose and stepwise ascending dose administration. The primary endpoints of the study include AE, vital signs, clinical laboratory results, and ECG results. The dosing regimen for the trial drug is as follows:Screenshot source:Drug Clinical Trial Registration and Information Disclosure PlatformAZD5492 is the world's firstCD20/TCR/CD8 Trispecific Antibody, which was submitted for clinical application in China in August 2024 and received its first clinical approval in October for use.Recurrent or Refractory B-Cell Malignancies. In April 2025, the drug was approved for clinical use again in China, forSystemic Lupus Erythematosus and Idiopathic Inflammatory Myopathies, achieving a crossover from oncology to autoimmune diseases.Screenshot source: Insight databaseInsight database shows that the drug has currently initiated 2 clinical trials, which are being conducted simultaneously.
Screenshot source: Insight databaseScan the WeChat QR code, add the editor of the Antibody Circle, and those who meet the requirements can join the Antibody Circle WeChat group!Please indicate: Name + Research Direction!
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