Zhiran Medical Secures Over RMB 300 Million Series A Funding Led by Legend Capital and IDG Capital to Advance Invasive Flexible Brain-Computer Interface Platform

Since its inception, BCIFlex has resolutely chosen the path widely recognized as the most challenging in the industry—invasive brain-computer interfaces—a technical route also adopted by Musk's Neuralink team. This strategic decision stems from BCIFlex's profound insight into the essence of brain-computer interface technology.Invasive solutions based on ultra-thin flexible electrodes represent the ultimate form of brain-computer bidirectional interaction technology and are key to achieving more efficient and precise human-computer interaction.

Electrodes are the core of the development of invasive brain-computer interfaces. Traditional rigid electrodes cause significant implantation damage and are prone to issues with brain tissue after implantation.Relative displacement occurs, triggering inflammatory responses and affecting the long-term stable acquisition of EEG signals. After 2010, with advancements in micro-nano processing technology and advanced material techniques, high-throughput flexible electrodes emerged, becoming a core competitive advantage for invasive brain-computer interface R&D companies.

BCIFlex's R&D team has been deeply engaged in the research field of flexible electrode materials for decades. The team's self-developed invasive high-throughput flexible electrode has been granted patents in both China and the United States, setting a precedent in the industry.This electrode is made of ultra-thin flexible material, with micron-level thickness that significantly reduces its proportion in the brain and minimizes implantation damage. It has passed biocompatibility tests, and its mechanical properties match excellently with brain tissue, ensuring safe implantation.

In response to the electrode displacement issues encountered in Neuralink's initial clinical trials, the BCIFlex team was well-prepared: their innovative anti-dislodgement electrode design effectively prevents relative movement between the electrode and brain tissue, significantly reducing inflammatory responses, and overcoming the industry-wide challenge of long-term stable signal acquisition.

Invasive brain-computer interface technology is a complex systematic engineering. While continuously consolidating its core advantage in flexible electrodes, BCIFlex has proactively laid out key aspects of invasive brain-computer interfaces. The company not only independently developed core components such as hardware systems, software and decoding algorithms, and implantation robots, but also built clinical-grade micro-nano processing workshops and GMP workshops spanning over a thousand square meters. Thus,BCIFlex has built a complete closed-loop from research and development to scaled production, achieving full independent control of clinical-grade products.This systematic layout provides a solid guarantee for the application of future medical scenarios.

In terms of technology development, BCIFlex has further independently developed deep neural network algorithms and built a high-precision EEG data platform with pre-trained neuronal EEG models, thereby achieving high-precision, high real-time, and highly versatile online decoding.To promote large-scale clinical application in the future, an automatic implantation robot has been developed to achieve precise and efficient automatic electrode placement.