Home Professors Zhang Yan and Guo You Pioneered the First National Clinical Application of DEEPQUAKE Peripheral Lithoplasty System

Professors Zhang Yan and Guo You Pioneered the First National Clinical Application of DEEPQUAKE Peripheral Lithoplasty System

Nov 07, 2025 08:30 CST Updated 08:30
Trulive

Structural Heart Disease Device Developer

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In the field of pan-vascular intervention, the treatment of calcified lesions is one of the key and difficult points in clinical practice. Produced by Trulive and promoted by Grand Pharmaceutical Group Limited,DEEPQUAKE Peripheral Vascular Intravascular Shockwave SystemOfficially launched (Approval No. 20243012335 in China). This system is suitable for the pretreatment of calcified lesions and balloon dilatation in the iliac artery, femoral artery, popliteal artery, renal artery, and infrapopliteal arteries, providing new treatment options for clinical use.


This issue is shared with everyoneFirst Application of DEEPQUAKE Peripheral Shock Wave System in China — A Case of Lower Limb Artery (Left Superficial Femoral Artery, Popliteal Artery) Atherosclerotic Occlusive Disease, by the Fourth Affiliated Hospital of Guangzhou Medical UniversityProf. Zhang Yan / Prof. Guo You TeamCollaboration completed, welcome everyone to read, learn, exchange, and discuss.



Features of DEEPQUAKE Peripheral Shock Wave System


Advantage 1LargerPulse Energy

  • Energy adjustable in five levels, with the highest energy reaching 3.2kV (fixed energy of 3.0kV for similar products).

Gear

Energy

Gear 1

2.8kV

Level 2

2.9kV

3-speed

3.0kV

4-speed

3.1kV

5 levels

3.2kV


Advantage 2MoreNumber of electrodes

  • The balloon is equipped with one pair of electrodes every 8mm, and the three lengths of 40/60/80mm have 4/6/8 pairs of electrodes respectively, ensuring uniform energy release. Treatment stitching does not require "Overlapping".

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40mm

4 pairs of electrodes

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60mm

6 pairs of electrodes

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80mm

8 pairs of electrodes


Advantage 3LongerBalloon Length

  • Provides an 80mm length balloon, more suitable for long lesions.Reducing operation time and IVL treatment frequency, cost-effective

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Surgeon's Evaluation

Professor Zhang Yan from the First Affiliated Hospital of Jinan University

▲Click to play video


Case Brief

Patient Basic Information

Patient:Female, 76 years old.

Chief Complaint:Left foot pain and ulcer for more than half a year.

History of Present Illness:The patient reported that about half a year ago, without obvious cause, pain and skin lesions appeared on the left foot, with a wound approximately 2*2 cm in size. No special treatment was given, and the symptoms gradually worsened. Currently, there is local redness, swelling, ulceration, and exudation on the left foot. The patient came to our outpatient department today for further treatment.The patient is admitted to our department with a tentative diagnosis of "Lower Limb Skin Infection (Left Foot)." Recently, the patient has been in good mental state and spirit, with normal bowel and bladder functions, good sleep, and no significant weight loss.

Past Medical History:History of hypertension for over 10 years, long-term oral administration of nifedipine, with blood pressure under fair control; history of diabetes for over 10 years, taking oral hypoglycemic drugs (details unknown); denies history of chronic bronchitis and emphysema; denies history of hepatitis; denies history of tuberculosis; denies history of other infectious diseases; denies history of blood transfusion; denies history of other trauma; denies history of surgery; denies history of allergies.

Physical Examination:T:36.5°C, P: 80 beats/min, R: 18 breaths/min, Bp: 120/75 mmHg; clear consciousness, clear speech, well-developed, natural expression, cooperative during examination. No jaundice, no ecchymosis or petechiae on the skin and mucous membranes, no enlargement of superficial lymph nodes; no deformity of the skull, no abnormality of the conjunctiva, no scleral icterus. Normal lips, tongue in midline, no deviation of the mouth corner, soft neck, no enlargement or tenderness of bilateral thyroid glands, no vascular murmur, trachea in midline, no jugular vein distension. Symmetrical chest without deformity, no abnormality of chest wall veins, clear breath sounds in both lungs, no dry or wet rales heard, normal percussion sound over both lung fields. No bulge in the precordial area, normal apical impulse, no palpable thrill, no pericardial friction rub, no cardiac enlargement, heart rate 80 beats/min, regular rhythm; no murmurs heard in any valve auscultation areas. Flat abdomen, no visible gastroenteric pattern, no visible peristaltic waves, soft throughout, no tenderness, no rebound tenderness, liver not palpable below the costal margin, spleen not palpable below the costal margin. Anus and external genitalia not examined. Left foot pain, skin lesion, no edema in other limbs, no deformity, redness, swelling, or tenderness in limb joints, full range of motion, bilateral knee reflexes present. Normal physiological curvature of the spine, no tenderness on percussion of the spine, normal physiological reflexes, pathological reflexes not elicited.

Rutherford Classification:Level 5

Preoperative Examination

Ultrasound Examination:

  1. Severe stenosis with segmental sclerotic occlusion in the left femoral artery, bilateral posterior tibial arteries, and dorsalis pedis arteries.

  2. Bilateral femoral veins, popliteal veins, anterior tibial veins, and posterior tibial veins are patent with smooth blood flow.

  3. Atherosclerosis of bilateral femoral arteries, right femoral artery, and bilateral anterior tibial arteries.

CT Scan:

  1. The lumen of the lower segment of the abdominal aorta and bilateral common iliac arteries is narrowed by approximately 30-40%; the lumen of the bilateral internal iliac arteries is narrowed by approximately 40-50%; the lumen of the lower segment of the right femoral artery and the upper-middle segment of the left femoral artery is narrowed by approximately 60-80%; the lumen of the bilateral leg arteries is narrowed by approximately 50-70%; the bilateral peroneal arteries are not visible, suggesting severe stenosis to occlusion; the lumen of the bilateral anterior tibial arteries is narrowed by approximately 60-80%, with some distal vessels not visible; the lumen of the bilateral posterior tibial arteries is narrowed by approximately 50-60%.

  2. Right Femoral Neck Fracture.

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Diagnosis and Surgical Strategy

Preoperative Diagnosis:Lower Extremity Arteriosclerosis Obliterans with Gangrene (Rutherford Grade IV/Fontaine Stage IV); Type 2 Diabetes; Hypertension.

Lesion Grading:TASC D grade/PACSS grade 4 lesions.

Proposed Surgical Strategy:Abdominal Aortic Angiography, Lower Limb Arterial Angiography, Lower Limb Arterial Balloon Dilatation and Angioplasty.

Lesion Location:Left superficial femoral artery, popliteal artery.

Surgical Approach:Right common femoral artery.

Baseline Angiography

Angiography revealed a long segment occlusion of the superficial femoral artery, severe calcification of the arterial wall, visualization of the popliteal artery through collateral circulation, unclear imaging of the infrapopliteal arteries, and slow blood flow.

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Lesion Opening Process

With the support of CXI catheter, the V18 guidewire successfully passed through the lesion segments of the superficial femoral artery and popliteal artery, but the balloon could not pass smoothly. Later, it was changed to V-14 guidewire with a 3.0*150mm balloon, which passed smoothly and performed pre-dilation.

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Shockwave BalloonLesion Management Process

A 3.0*150mm balloon was used for pre-dilation of the superficial femoral artery and popliteal artery lesions, followed by the introduction of a DEEPQUAKE shockwave balloon 5.0*60mm to sequentially perform shock treatment on the lesion sites. A total of 10 cycles of shock treatment were conducted at level 5.After contrast imaging, the unsatisfactory lesion segment was treated again at level 5, with gradually increasing treatment pressure, followed by 5 cycles of shockwave therapy, totaling 450 shocks.The effect has reached an ideal state.

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4atm

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6atm

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10atm

Disease Treatment Process

A 5.0*220mm drug-coated balloon was used to treat lesions in the superficial femoral artery and popliteal artery. Subsequently, local stenosis was dilated, and finally, 5.5*10mm and 6*8mm arterial stents were implanted.

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Local dissection and residual stenosis were treated with stent implantation, and the stent was well-expanded.

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DCB Treatment for Full-Length Lesions

Final Angiography

The occluded lesion has been fully recanalized, and blood flow has returned to normal.

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Preoperative and Postoperative Comparison

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Preoperative

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Postoperative



Expert Introduction

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Professor Zhang Yan

Director Physician and Associate Professor at the First Affiliated Hospital of Jinan University, Master's Graduate Supervisor, graduated with a bachelor’s degree from Sun Yat-sen University of Medical Sciences, and obtained master’s and doctoral degrees from Jinan University. Spent one year in Germany as a visiting scholar. With over 20 years of experience in interventional radiology, primarily focuses on endovascular treatments for tumors and peripheral vascular diseases, especially limb salvage treatment for arteriosclerosis obliterans and diabetic foot, playing a pioneering leading role in southern China. Currently serves as: - Vice Chairman of the Lower Extremity Artery Committee under the Chinese Division of the International Union of Angiology (IUA);- Vice Chairman of the Expert Committee on Aortoiliac Artery Surgery of the Peripheral Vascular Disease Committee of the Chinese Society of Microcirculation;- Vice Chairman of the Lower Extremity Artery Group of the Endovascular Society of the Chinese Medical Doctor Association;- Vice Chairman of the Interventional Therapy Branch of the Guangdong Hospital Management Association;- Deputy Director of the Peripheral Vascular Disease Professional Committee of the Guangdong Hospital Management Association;- Deputy Director of the Vascular Medicine Professional Committee of the Guangdong Health Management Society;- Standing Committee Member of the Interventional Branch of the Guangdong Medical Association of the Chinese Medical Association;- Standing Committee Member of the Guangdong Interventional Physicians Branch of the Chinese Medical Doctor Association;- Standing Committee Member of the Peripheral Vascular Disease Management Branch of the Chinese Geriatric Medical Society;- Standing Committee Member of the Chinese Venous Treatment Committee;- Committee Member of the Endovascular Treatment Branch of the Chinese Medical Doctor Association;- Committee Member of the Oncology Imaging and Intervention Diagnosis and Treatment Professional Committee of the Guangdong Anti-Cancer Association;- Committee Member of the Hemodialysis Access Group of the Vascular Surgery Branch of the China International Exchange and Promotive Association for Medical and Healthcare.


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Professor You Guo

Director of the Department of Interventional Vascular Surgery, Fourth Affiliated Hospital of Guangzhou Medical University,Chief Physician, Doctor of Medicine, Master's Graduate Supervisor, Lingnan Renowned Doctor,Engaged in interventional and vascular surgery for 28 years.Skilled in interventional minimally invasive treatment for vascular and tumor conditions;The interventional vascular surgeon who first mastered the Magnetic Resonance-guided Focused Ultrasound (MRgFUS) technology in China.

Vice Chairman of the Youth Committee of Intracavitary Radiation Oncology, China Pharmaceutical Education Association;Vice Chairman of the Peripheral Vascular Disease Committee of the Guangdong Provincial Association of Traditional Chinese Medicine;Vice Chairman of the Professional Committee on Tumor Interventional Therapy, Guangdong Association of Integrated Traditional Chinese and Western Medicine;Vice Chairman of the Peripheral Vascular Disease Branch of the Guangdong Precision Medicine Application Society;Standing Committee Member of the Vascular Surgery Professional Committee of the Guangdong Provincial Clinical Medical Association;Standing Committee Member of the Vascular Disease Diagnosis and Treatment Management Professional Committee of the Guangdong Provincial Hospital Association;Standing Committee Member of the Vascular Medicine Professional Committee of the Guangdong Health Management Association;Standing Committee Member of the Vascular Surgery Branch of the Guangzhou Medical Association;Member of the Expert Group of Guangzhou Vascular Surgery Medical Quality Center.


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Professor Cui Haoran

The Fourth Affiliated Hospital of Guangzhou Medical University,Attending Physician, Member of the Interventional Medicine Branch of the Guangdong Health Management Association, Fourth Affiliated Hospital of Guangzhou Medical University; Member of the Interventional Medicine Branch of the Guangdong Traditional Chinese Medicine Association;Graduated with a master's degree, engaged in peripheral intervention and imaging diagnosis for nearly 10 years. Skilled in diagnosing various complex diseases through CT and MRI, followed by treatment using minimally invasive interventional methods. Possesses extensive clinical experience in treating various vascular diseases such as liver cancer, liver metastases, biliary obstruction, deep vein thrombosis of the lower extremities, hepatic vein-inferior vena cava stenosis, gastrointestinal bleeding, hemoptysis, and uterine hemorrhage. Proficient in various puncture approaches, capable of independently performing PTCD, lower extremity arterial recanalization, TACE, filter insertion/removal, biopsy, uterine artery embolization, gastroduodenal artery embolization, bronchial artery embolization, hepatic vein-portal vein balloon dilation, various angiographies, and dialysis catheterization among other interventional procedures. Has conducted in-depth research and accumulated rich clinical practice in the interventional treatment of mid-to-late stage liver cancer. Published numerous articles in core journals both domestically and internationally, with research achievements widely recognized.


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Professor Zhang Chu Tu

Attending Physician,Bachelor of Clinical Medicine,Bachelor's Degree.

Proficient in the diagnosis and treatment routines and principles of common diseases in various departments; skilled in the use of various rescue instruments and procedures; proficient in DSA operations, information acquisition, and high-pressure injector settings; skilled in various puncture techniques; experienced in great saphenous vein radiofrequency ablation, varicose vein stripping, inferior vena cava filter implantation, lower limb venous thrombectomy, lower limb arterial balloon dilation angioplasty, and transjugular intrahepatic portosystemic shunt (TIPS); capable of independently completing abdominal aorta + lower limb arteriovenous angiography, full cerebral angiography, etc.; able to assist senior physicians in completing endovascular angioplasty for lower limb arteries and veins, biliary stent angioplasty, ruptured vessel embolization, tumor vascular embolization chemotherapy, endovascular exclusion for aortic dissection/aneurysm, and intracranial occluded vessel thrombectomy, etc.



Trulive


Jiangsu Trulive Medtech Co., Ltd. focuses on the field of cardiovascular diseases, which have extremely high mortality and disability rates and remain a gap in the domestic market. Its business comprehensively covers multiple interventional treatment areas such as heart valves, peripheral, and coronary arteries. It is a platform enterprise that takes the lead in providing one-stop innovative solutions for blood flow management globally. With strong research and development capabilities and a senior, complete operational team, Trulive Medtech has developed high-quality domestically produced medical devices with independent intellectual property rights and comprehensive solutions, filling the gap in China’s high-end cardiovascular interventional medical devices. This provides more advanced and diverse treatment options for Chinese doctors and patients. Meanwhile, Trulive Medtech, based in China and strategically expanding worldwide, continues to upgrade through technological innovation and development, accelerating the expansion of its global commercial network. In many细分 markets within the cardiovascular intervention field that have long been monopolized by imported products, the company offers "Chinese solutions" and contributes "Chinese wisdom."

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