Zunyi Medical University Affiliated Hospital Completes One of China’s First ICE-Guided RhythPulse® PFA Ablations Using XuanYu Medical's Innovative System
ShineyoMedical
Provider of Atrial Fibrillation Electrophysiology and Peripheral Vascular Intervention Solutions
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ENTERPRISE
Recently, the electrophysiology team of the Cardiology Department at the Affiliated Hospital of Zunyi Medical University successfully completed one of the first cases in China using the domestically produced ShineyoMedical RhythPulse under ICE guidance.®PFA Pulsed Field Ablation Surgery. The validation of PFA technology's comprehensive advantages in effectiveness, safety, and efficiency; marks that China's indigenous PFA technology is developing comprehensively, providing a safer and more efficient new treatment option for patients suffering from atrial fibrillation.
Patient Information
Patient: Female, 57 years old
Chief Complaint: Palpitations for 1 Year, Recurrent for 20 Days
Present Illness: A 57-year-old female patient was admitted to the hospital due to "palpitations for 1 year, recurring for 20 days." Over the past year, the patient has repeatedly experienced palpitations accompanied by dizziness and amaurosis, but without nausea or vomiting, and no chest tightness or chest pain. For the past 20 days, the patient's palpitation symptoms have occurred more frequently with prolonged duration, lasting from a few minutes to about ten minutes each time. She then visited the local hospital where further examinations suggested "atrial fibrillation." For further diagnosis and treatment of atrial fibrillation, she visited our hospital’s outpatient department and was admitted to our department with a diagnosis of "paroxysmal atrial fibrillation." Since the onset of the disease, her mental state and sleep have been fine, appetite is normal, bowel movements and urination are regular, and there has been no significant change in weight.
Preoperative Diagnosis: Paroxysmal Atrial Fibrillation
Communicate with the patient and family members. The current diagnosis is paroxysmal atrial fibrillation, which indicates the need for catheter ablation. Generally, traditional radiofrequency ablation is chosen, but the newer pulsed field ablation for atrial fibrillation is also an option. After fully informing them of the pros and cons of both procedures, the patient and family decided to choose ShineyoMedical RhythPulse.®Treatment with PFA pulsed electric field ablation.
Surgical Procedure
During the pulse atrial fibrillation surgery under deep sedation, the patient lies supine, with routine disinfection and draping. The puncture site is locally anesthetized with 2% lidocaine. Under ultrasound guidance, three punctures are made in the right femoral vein to insert the coronary sinus electrode and the AgileView ICE intracardiac echocardiography catheter. After successful transseptal puncture guided by ICE, heparin is administered for systemic anticoagulation. ShineyoMedical's RhythPulse is selected.® A 10mm ring-shaped pulsed electric field ablation catheter was used for three-dimensional pulsed electric field ablation, with continuous ICE monitoring of the catheter position, contact, pericardial conditions, and thrombosis during the procedure.
ICE-Guided Atrial Septal Puncture
ICE-guided PFA Catheter in Pulmonary Vein
ICE-guided PFA Catheter in the Superior Vena Cava
The patient underwent left-sided PVI while in sinus rhythm. Atrial fibrillation (AF) occurred during the ablation of the left inferior pulmonary vein. After completing bilateral PVI, AF had not terminated, so additional ablation lines were applied to the posterior box, superior vena cava, and tricuspid isthmus; however, AF still did not terminate. Subsequently, Marshall vein ethanol ablation was performed, during which AF converted to atrial tachycardia (AT). The A-wave at CS 9-0 was the earliest, suggesting a right atrial origin. RhythPulse was then used.®️-PFA catheter was withdrawn to the right atrium, and activation mapping showed an origin from the superior vena cava. Focal ablation was performed below the original isolation line at the septal side of the superior vena cava, after which sinus rhythm was restored. Upon completion of the procedure, electrophysiological examination did not induce any other arrhythmias. Bidirectional conduction block was achieved in both pulmonary veins and the isolation lines. ICE showed no pericardial effusion or thrombus, and the surgery was successfully completed.
Academic Leader
Shi Bei
Affiliated Hospital of Zunyi Medical University
Director of Cardiovascular Disease Hospital, Zunyi Medical University, Second-level Professor, Doctoral Supervisor; Expert with Outstanding Contributions to the National Health Commission of China (NHC) as a Middle-aged and Young Expert; National Committee Member of the Chinese Society of Cardiology (CSC) and Deputy Head of the Clinical Research Group; National Committee Member of the Cardiovascular Physicians Branch of the Chinese Medical Doctor Association and Deputy Head of the Arrhythmia Group; Vice Chairman of the Cardiovascular Disease Branch of the Chinese Stroke Association; Vice Chairman of the Grassroots Cardiovascular Disease Branch of the Chinese Society of Cardiothoracic Vascular Anesthesiology; Vice Chairman of the Specialized Committee on Cardiac Intervention and Rehabilitation of the Chinese Rehabilitation Medical Association; Vice President of the China Metabolic Alliance/China Chest Pain Alliance; Chairman of the Electrocardiology and Pacing Branch of the Guizhou Medical Association.
Principal investigator of 6 projects funded by the National Natural Science Foundation of China (General and Regional programs); published over 300 papers as the first or corresponding author (58 SCI papers, total IF 349, average 6.05); editorial board member for the chapters on arrhythmia in the 9th and 10th editions of the Chinese national five-year undergraduate textbook "Internal Medicine" (People's Medical Publishing House); editorial board member of journals such as "Asian Heart Journal," "Heart & Mind," and "Chinese Journal of Cardiology"; editor-in-chief of "Standardized Training Course for Emergency PCI at the Grassroots Level" (Science Press).
Zhaoran Zun
Affiliated Hospital of Zunyi Medical University
Director of the Department of Cardiology, Affiliated Hospital of Zunyi Medical University, Doctor of Medicine, Professor, Doctoral Supervisor; Member of the 11th and 12th Youth Committee of the Cardiovascular Disease Branch of the Chinese Medical Association; Vice Chairman of the Cardiovascular Disease Branch of the Guizhou Medical Association, and Leader of the Cardiac Critical Care Group.
Principal Investigator of 1 sub-project under the National Key Science and Technology Special Project, and 3 projects of the National Natural Science Foundation of China; awarded 2 second prizes of the Guizhou Province Science and Technology Progress Award, and published over 40 research papers.
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Expert Profile
Liu Xiping
Affiliated Hospital of Zunyi Medical University
Chief Physician, Master's Graduate Supervisor; Executive Deputy Director of the Atrial Fibrillation Center at Zunyi Medical University Affiliated Hospital; Vice Chairman of the Guizhou Provincial Medical Association's Electrophysiology and Pacing Branch; Member of the Cross-Strait Hypertension Professional Committee; Vice Chairman of the Guizhou Atrial Fibrillation Center Alliance.
Li Li
Affiliated Hospital of Zunyi Medical University
Director of Cardiology, Affiliated Hospital of Zunyi Medical University, Member of the Guizhou Branch of the Chinese Society of Cardiac Electrophysiology and Pacing, Standing Committee Member of the Cardiovascular Disease Professional Committee of the Guizhou Rehabilitation Medical Association, Standing Committee Member of the Cardiovascular Specialty Committee of the Guizhou Integrated Traditional Chinese and Western Medicine Society, and Mentor of the Arrhythmia Training Base of the National Health Commission and the Chinese Medical Doctor Association.
Wang Yan
Affiliated Hospital of Zunyi Medical University
Doctor of Medicine, Associate Chief Physician, Doctoral Supervisor, "Thousand Talents Plan" Expert of Guizhou Province, "Clinical Master" in the "12345 Talent Plan" of Zunyi Medical University, and "Outstanding Young Talent" of the Affiliated Hospital of Zunyi Medical University.
Principal Investigator of 5 projects funded by the National Natural Science Foundation of China, including 1 General Program project, 1 Youth Fund project, and 3 Regional Fund projects. Leader of the Innovative Team for Basic and Clinical Translational Research on Myocardial and Vascular Injury Repair at Higher Education Institutions in Guizhou Province. Principal Investigator of 2 provincial/ministerial-level projects and 2 municipal-level projects.
Published 20 SCI papers as the first author, with a cumulative impact factor of 120, and the highest impact factor of a single paper being 12.4. Published 5 papers in core journals recognized by Beihang (Peking University). Main contributor to the Second Prize of Science and Technology Progress Award in Guizhou Province, and the Second Prize of Science and Technology Award from the Guizhou Medical Association (as the principal investigator). Invited multiple times to present at authoritative academic conferences in China, including ECS and TCT. Led two provincial-level new technology projects and holds one invention patent.
Member of the 12th Precision Medicine Group of the Chinese Medical Association; Youth Editorial Board Member of the Chinese edition of Circulation – Special Issue on Arrhythmia and Electrophysiology; Corresponding Editorial Board Member of the "Chinese Journal of Cardiology" (Online Edition); Corresponding Editorial Board Member of the "Chinese Journal of Tissue Engineering"; Member and Secretary of the First Committee of the Cardiovascular Branch of the Zunyi Medical Association; Experienced in the diagnosis and treatment of common and frequently-occurring cardiovascular diseases, with expertise in catheter ablation for arrhythmias and the management of cardiac critical care.
Gao Yixuan
Affiliated Hospital of Zunyi Medical University
Attending Physician, Master of Medicine, Department of Cardiology, Affiliated Hospital of Zunyi Medical University; Secretary of the Arrhythmia Training Base, Affiliated Hospital of Zunyi Medical University; Independent Operator of Catheter Ablation for Atrial Fibrillation, Radiation-Free Atrial Fibrillation Operator; Secretary and Lecturer of Guizhou Province Atrial Fibrillation Center, CDQI; Tutor for Arrhythmia Intervention Training, Chinese Medical Doctor Association; Technical Advisor Expert for LAmbre Left Atrial Appendage Occluder.
Graduated from Zunyi Medical College Zhuhai Campus in 2009, has been engaged in the clinical diagnosis and treatment of cardiovascular diseases as well as scientific research and teaching work for a long time. In 2018, underwent advanced training in catheter ablation for arrhythmia at Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University. Skilled in the diagnosis and treatment of various types of arrhythmias, common diseases, frequently-occurring diseases, and critical emergencies in cardiology.
Chen Lei
Affiliated Hospital of Zunyi Medical University
Attending Physician, Master's Degree, Graduated from West China Clinical Medical College of Sichuan University. Long-term engagement in the diagnosis and treatment, teaching, and research of cardiovascular diseases. Specializes in interventional diagnosis and treatment of arrhythmia, CHRS radiation-free catheter ablation for atrial fibrillation.
Shen Youcheng
Affiliated Hospital of Zunyi Medical University
Master of Medicine, Ph.D. candidate at Zunyi Medical University. Published 4 SCI papers as the first/co-first author, proficient in the diagnosis and treatment of common and frequently occurring cardiovascular diseases. Completed a fellowship in catheter ablation at Anzhen Hospital in 2024, primarily focusing on catheter ablation therapy for arrhythmias.
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【ShineyoMedical RhythPulse®-PFA System】
ShineyoMedical's RhythPulse®-PFA System is the first approved Pulse Field Ablation (PFA) system in China that integrates multi-channel, large focal point, and targeted ablation, primarily used for treating rapid arrhythmias such as drug-refractory and recurrent atrial fibrillation. Its core advantages include:
Large Focal Design:Using the world's first 10mm ring ablation catheter, a single discharge can cover a lesion area with a diameter of 10mm, increasing the ablation efficiency by more than three times compared to traditional technology.
Targeted Ablation Technology:Equipped with an intelligent contact detection module, it monitors the contact status between the electrode and myocardial tissue in real time, reducing the risk of hemolysis caused by ineffective discharges, and decreasing postoperative plasma-free hemoglobin content by 50%.
Excellent clinical validation:In the clinical trial of 151 cases, the immediate success rate was 100%, and the success rate of atrial fibrillation treatment at 12 months post-operation reached 85.07%, achieving an internationally leading standard.
