Recently, the Xbiome scientific team andAssociate Professor Sun Quancai and Assistant Professor Peng Ye from the Faculty of Medicine at Macau University of Science and TechnologyThe joint research article "Combined Administration of Bifidobacterium adolescentis XA-1069 and Lactobacillus plantarum XA-6827 Attenuates Obesity in High-Fat Diet-Induced Obese Mice" was published inFood Science and Human WellnessPublished, the latter isOne of the international journals with the highest impact factor in the food field(Impact Factor 8.45, CAS Q1 Zone).
Multi-target synergy, fat reduction effects advance layer by layer
Currently, obesity has become a major global health challenge, and traditional weight loss methods have significant health risks such as severe side effects and a high risk of rebound.
This article focuses on the launch of XbiomePostbiotic Combination of Lactiplantibacillus plantarum XA-6827 and Bifidobacterium adolescentis XA-1069, conducting research on fat reduction and weight loss effects, using microorganisms as a tool to open up a safe and efficient new path for weight loss. The article points out that in animal models of obesity, this combination demonstrates comprehensive anti-obesity capabilities.
1. Weight Management Master:After an 11-week intervention, the model animals showed a significant 30.6% reduction in body weight compared to the control group, effectively curbing weight gain and avoiding the "rebound weight increase" phenomenon.
2. Precision Strike on Fat:Significantly reduce epididymal white adipose tissue mass by 40%, decrease adipocyte hypertrophy by 22%, and lower the proportion of visceral fat,告别臃肿体态与健康隐患.
3. Comprehensive Optimization of Blood Lipids:Targeted reduction of serum triglycerides and low-density lipoprotein cholesterol (bad cholesterol) levels, while regulating total cholesterol balance, safeguarding cardiovascular health.
4. Liver Metabolism Repair:Significantly downregulate the expression of obesity- and inflammation-related genes such as ppar-γ, fas, and tnf-α in the liver, while activating the key gene acox for fatty acid oxidation, fundamentally improving metabolic disorders.
5. Gut Microbiota Remodeling:Powerfully PromoteAkkermansia, AllobaculumThe proliferation of "lean bacteria" (increased 2.3 times compared to the control group) was observed, while inhibition occurred.Dorea, FaecalibaculumThe abundance of "obesogenic bacteria" restores the balance of the intestinal microecology, turning the gut environment into a fat-reduction aid.
6. Precision Metabolic Regulation:Bidirectional regulation of intestinal metabolite levels, upregulating beneficial metabolites downregulated by high-fat diets, and inhibiting abnormally elevated harmful metabolites, comprehensively improving the metabolic environment.
Scientific evidence-based mechanistic research and substantial scientific data indicate that the use of a postbiotic combination of Lactiplantibacillus plantarum XA-6827 and Bifidobacterium adolescentis XA-1069No need to change diet or exercise habits,which can achieve multi-target intervention for obesity and metabolic issues through "intestinal regulation + metabolic improvement + inflammation relief."Achieve "Easy Fat Loss Without Rebound",Avoids the gastrointestinal discomfort, dizziness, fatigue, and muscle loss side effects brought by most current weight-loss drugs, making the weight-loss process more comfortable and safer.
China's "Intelligent" Safe Fat Reduction Black Technology
Xbiome's scientific team introduced that this golden postbiotics combination, derived from the gut of healthy Chinese people, is truly suitable for the Chinese population, referred to as "Chinese bacteria." Leveraging the industry-leading AI+BT technology platform, and through the "double validation" experiments of sequence alignment and protein structure simulation, Xbiome has meticulously selected two "winners" — XA-6827 and XA-1069 — from its proprietary gut strain library (XGB) of over 16,000 strains. Their preservation numbers are CGMCC No.31383 and CGMCC No.31381, respectively.Subsequent mechanistic studies and in vivo research have both confirmed the excellent performance of the XA-6827 and XA-1069 strain postbiotic compositions in anti-obesity efforts.
Since 2024, the Xbiome scientific team has been collaborating with Associate Professor Sun Quancai and Assistant Professor Peng Ye from the Faculty of Medicine at Macau University of Science and Technology on a joint research project targeting anti-obesity postbiotics. Concurrently with the official publication of the research article,The jointly filed invention patent application, "A Plant Lactobacillus with Weight-Reducing Effects and Its Postbiotic Composition," has also entered the substantive examination stage.The application materials introduce that in a high-fat diet animal model, the strain and its postbiotic composition can address obesity from the perspective of gut microbiota, achieving multi-target intervention in obesity-related physiological and pathological processes.
It is worth mentioning that,StabilityIs another major advantage of the XA-6827 and XA-1069 postbiotic compound. Unlike live probiotics, this combination...Inactivated bacterial bodies and metabolitesAt its core, after inactivation treatment, the key functional components are still fully retained. Therefore, it possesses the characteristics of being heat-resistant, acid-resistant, and bile salt-resistant, requiring no cold chain storage and maintaining stable efficacy at room temperature.Providing a brand-new intestinal microecology solution for various consumption scenarios such as health food and beverages.
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This article inFood Science and Human WellnessThe official publication marks that the postbiotic combination of Lactiplantibacillus plantarum XA-6827 and Bifidobacterium adolescentis XA-1069, as a scientifically evidenced innovative solution for weight management, has gained authoritative academic recognition.Xbiome's new product, developed based on this combination, is about to hit the market.Look forward to bringing a scientific, light, and healthy new lifestyle to the urban population with fast-paced lives, who find it inconvenient to change their diet and living habits.
Source: https://www.sciopen.com/article/10.26599/FSHW.2025.9250892
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