Sainbio Biotech Secures Investment from Pine Seed Capital for Its Nanotechnology-Based Antiviral Spray Effective Against SARS-CoV-2 on Mucosal Surfaces

VCBeat has learned that Sinovate Capital announced on February 29 that it had swiftly invested in Chengdu Sainbei Biotechnology Co., Ltd. during the Spring Festival holiday. The company’s “cutting-edge technology products” are playing a significant role in the prevention and control of the COVID-19 epidemic.

Since the outbreak of the epidemic, to support epidemic prevention and control efforts, Sinovation Capital has swiftly leveraged its long-standing expertise and acumen in hard-tech investment to identify hard-tech companies worldwide that could have a direct impact on epidemic prevention and control.

Although the number of new COVID-19 cases in China has declined significantly, with the changing epidemic situation in countries such as the United States and Italy, and particularly given the large-scale population movement and gathering brought about by the resumption of work and production domestically, society as a whole must remain vigilant against the COVID-19 pandemic for an extended period.

According to some scientists and epidemiologists at the World Health Organization, the novel coronavirus may continue to coexist with human society, with asymptomatic carriers being the most troubling concern.During the pandemic, the primary source of infection was individuals carrying the SARS-CoV-2 virus. Some of these individuals remained asymptomatic, and their nucleic acid tests for the virus could even yield negative results. Before effective vaccines became available, no method was found to effectively block transmission other than physical isolation and strict personal protective measures. Asymptomatic carriers continued to exist among us, enabling the virus to infect vulnerable individuals through contact and respiratory droplets via the respiratory tract, oral cavity, and even mucous membranes. This was one of the key reasons why the outbreak was difficult to control and subsequently spread globally.

However, humans are social creatures. A vast amount of economic activity, social engagement, and daily life is inseparable from interpersonal interaction and contact.. Physical isolation can block viral transmission in the short term, but prolonged physical isolation and strict personal protective measures have an equally enormous impact and harm on socioeconomic, cultural, and daily life, and are completely unsustainable.

How to effectively prevent the spread of viruses while minimizing disruption to people’s normal production and daily life has become an urgent priority. In response to the emergency, masks, alcohol, disinfectants, and other protective supplies have become scarce commodities.However, alcohol and traditional disinfectants available on the market are highly irritating to the human body and even pose considerable risks. So, is there a method for disinfecting and eliminating the novel coronavirus that is both safe and effective, as well as convenient and relatively inexpensive?

Through thorough investigation, the investment team at Sinopharm Capital learned that a high-tech enterprise in Chengdu—Sainbei Biotechnology Co., Ltd.The innovative “black-tech” product—Nafuai Spray—obtained its medical device registration certificate last year. It is primarily indicated for chronic and hard-to-heal wounds, demonstrating significant efficacy in the eradication of persistent microbial infections (including viruses, mycoplasma, chlamydia, and bacteria) in advanced-stage diabetes.

During this epidemic, the Nafu Ai spray also demonstrated a significant virucidal effect against the novel coronavirus.Use. Unlike the chemical toxicity-based disinfection principles employed by all other disinfectants, this technology utilizes a comprehensive three-dimensional superposition of physical actions and nano-effects. By leveraging its unique free oxygen and nano-structure technology, it rapidly oxidizes the disulfide bonds in viral capsid proteins, causing denaturation of the capsid proteins and leading to viral disintegration. It further induces strand breakage in viral nucleic acids, thereby inactivating the virus. In addition to serving as an alternative to traditional disinfectant liquids such as alcohol, Naifuai Spray can be applied to mucous membranes, including those of the oral cavity, nasal passages, and eyes, effectively blocking the transmission and invasion of SARS-CoV-2 via mucosal routes.

This technology represents the pinnacle of scientific achievement by the ScienBay research team. Team member Professor Luo Zhongli earned his doctorate under Academician Zhang Shuguang, a globally renowned bioscientist, and completed his postdoctoral training under Academician Bengt Nordén, former Chair of the Nobel Committee for Chemistry.. The company boasts profound academic heritage and core foundational technologies. Notably, Zhang Shuguang is a scientist at the MIT Media Lab, a member of the Austrian Academy of Sciences, a member of the U.S. National Academy of Inventors, a Fellow of the American Institute for Medical and Biological Engineering, and an Honorary Professor at Shanghai Jiao Tong University and Sichuan University.

Academician Zhang Shuguang stated, “In patients with COVID-19 or among close contacts, the virus may adhere to the surfaces of various organs within the respiratory system. In the early stages, under favorable conditions, the virus can cause progressive damage to pulmonary cells, tissues, and other vital organs, thereby posing a threat to life. When the virus enters the body through the respiratory tract—such as via the oral cavity, nasal passages, eyes, and lungs—current medical treatments are unable to effectively halt its progressive damage to these organs.” To date, there are no effective medical interventions available; clinicians must wait for the virus to progressively attack the lungs and other vital organs, potentially endangering life. Consequently, patients typically seek hospital treatment only after symptoms have manifested.

“Is it possible to find a way to effectively eliminate the virus before it progressively destroys organs such as the lungs or causes death?”Recommended Cybenafu Ai Protocol："By using a spray method, microbes on the mucous membranes of the nasal cavity, oral cavity, eyes, and lungs, as well as the COVID-19 virus, can be eliminated within 30 seconds, effectively preventing viral attacks on the body and safeguarding life and health," said Academician Zhang Shuguang.。

Professor Luo Zhongli introduced that, while effectively curbing the spread of the virus, this technology also has the potential to provide a simple and rapid treatment for severe COVID-19 patients. The company plans to submit an application to the Sichuan Provincial Medical Products Administration, aiming to have the product classified as a Class II medical device as soon as possible, expand its scope of application, and quickly offer patients a novel and effective therapeutic option.

Through in-depth exchanges with Professor Luo Zhongli, founder of Cyenbay (a doctoral student of Academician Zhang Shuguang), Sinopharm Capital has learned that: “Currently, this solution can not only be used for the protection and prevention of frontline clinical medical staff, but also for the protection and prevention of suspected or confirmed patients, as well as individuals under voluntary isolation. It is more suitable for the general public. Due to relevant regulatory requirements, the use of this product for interventional treatment of patients with COVID-19 pneumonia is currently still in the clinical trial application stage.”

It is understood that,Currently, more than 100 hospitals across China, involving tens of thousands of frontline healthcare workers and members of the general public, are using Nafuai Spray for protection, with no reported cases of infection following its use.。

On February 24, the China-WHO Joint Expert Mission on COVID-19 reported that a total of 3,387 healthcare workers across 476 medical institutions in China had been infected with COVID-19. Several healthcare workers have died.

To protect the “most beautiful retrograders,” CytoBio donated large quantities of Nafuai Spray free of charge to frontline units combating the novel coronavirus, including Huoshenshan Hospital, Wuhan Taikang Tongji Hospital, the Liaoning Medical Team aiding Hubei, and the Wuhan Fire Eye COVID-19 Testing Laboratory, thereby safeguarding the health of healthcare workers through concrete actions.

 Sainbei Donates Nafuai Spray to Liaoning Medical Team Assisting Hubei and Frontline Journalists

Sainbei Donates Nafuai Spray to the First Affiliated Hospital of China Medical University

Since the onset of the COVID-19 pandemic, Sinoway Capital has fully leveraged its advantages as a hub-type and platform-oriented institution to actively participate in epidemic prevention and control. It not only donated RMB 10 million to co-establish the Peking University White Angel Guardian Fund, with a total scale of RMB 100 million, but also partnered with the Mammoth Foundation to upgrade nearly 20 testing laboratories across China, rapidly equipping them with capabilities for novel coronavirus detection. Furthermore, in collaboration with BGI and more than 200 other biotechnology enterprises, it covered 22 provinces, municipalities, and autonomous regions nationwide by providing professional personnel, testing equipment, and laboratories for deployment by local governments, thereby ensuring the testing needs for suspected COVID-19 cases and for employees returning to work.

Of course, as an investor, Sinopharm Capital has distributed the Nafu Ai spray to all employees as a benefit for personal protection. This is because safeguarding its employees is Sinopharm Capital’s most important responsibility.