Polaris × Tetramer Shop: Ultra-Fast, High-Throughput T Cell Immune Profiling Platform Files IPO Prospectus
Tetramer Shop
Cell Technology R&D Provider
Polaris Biology
Supplier of Single-Cell Precision Diagnosis Technology R&D and Clinical Applications
MHC Tetramer Staining technology is widely used for the detection and analysis of antigen-specific T cells. The new generation of MHC tetramer products developed by Tetramer Shop enables rapid, high-throughput preparation of tetramers within 30 minutes. Through this strategic partnership, Polaris Biology’s solutions support users in conducting high-throughput screening of T-cell epitopes alongside multiparametric “phenotype + function” analysis of T cells. Furthermore, all related products are fluorescently labeled to ensure compatibility with conventional flow cytometry analysis. This addresses the demands for speed, throughput, and cost-effectiveness in epitope mapping and T-cell analysis across fields such as T-cell biology research, neoantigen discovery, tumor immunotherapy development, and vaccine development.
The tetramer technology provided by Polaris Biology features the following characteristics:
1 Ultra-rapid preparation. Polaris Biology offers unique unloaded MHC tetramer products, enabling the preparation of various peptide-MHC tetramers in just 30 minutes with a peptide loading efficiency of over 90%;
2. Wide variety of MHC types and label options. The product catalog includes over 300 pre-made antigen-MHC tetramers, offering a choice of 19 fluorescent detection channels and 40 mass cytometry metal detection channels; tetramer staining experiments can be easily performed on flow cytometers and mass cytometers.
3. Ultra-high detection throughput. Polaris Biology’s customized solutions utilize metal-element combinatorial coding-labeled tetramers to enable high-throughput, rapid screening of over 100 distinct antigenic epitopes from tumors or viruses, while simultaneously performing “phenotype + function” analysis of more than 30 biomarkers on lymphocytes, including antigen-specific T cells.
“Since our initial contact, we have been deeply impressed by the professionalism and diligence of the Polaris Biology team,” said Søren N. Jakobsen, Founder and CEO of Tetramer Shop. “Polaris Biology has conducted numerous pioneering and advanced works in the field of single-cell analysis technology, making it the ideal partner for Tetramer Shop. We look forward to jointly exploring the Chinese market with them.”
In fields such as immunology research, antibody drug development, and vaccine development, high-throughput analysis of peptide-MHC complex and T-cell receptor (TCR) pairing, as well as T-cell function, is often required. However, due to limitations in the preparation time and cost of peptide-MHC tetramers, classic tetramer products are difficult to prepare rapidly, often requiring dozens of hours to complete antigen loading. Furthermore, the limited number of detection channels in conventional flow cytometry restricts its broad application. Mass cytometry technology achieves a qualitative leap in channel capacity by quantifying mass tags via metal ion systems. Through barcode design, it enables simultaneous high-throughput screening of T-cell antigen epitopes and multiparametric “phenotype + function” analysis of T cells.
About Polaris Biology's Mass Cytometry Immunology Solutions:
1. Antibody Panel: Polaris Biology offers more than 20 pre-formulated metal-tagged antibody panels, encompassing over 100 metal-tagged antibodies, to facilitate the rapid initiation of mass cytometry experiments.
2. Tetramer Staining Reagents (Tetramer): Polaris Biology offers cost-effective products, including pre-assembled tetramers, unloaded tetramers, and custom tetramers, to support immunological research and drug development efforts;
3 Service: Based on the mass cytometry platform, Polaris Biology also provides users with technical services such as in-depth immune profiling analysis, biomarker discovery, and tumor neoantigen screening.
About Polaris Biology
Polaris Biology is a leading single-cell precision diagnostics technology company, dedicated to the research, development, and manufacturing of tumor companion diagnostic solutions tailored to clinical needs. We provide accurate, safe, and reliable testing technologies to support more precise clinical diagnosis and treatment of cancer. We are committed to helping physicians obtain clear and definitive tumor information and evidence-based diagnostic and therapeutic insights in a timely manner, addressing the severe challenges facing modern medicine.
About Tetramer Shop
Headquartered in Copenhagen, Denmark, Tetramer Shop was founded by a team of senior immunologists. The company is dedicated to serving global customers, supporting academic research institutions and medical R&D laboratories in their development efforts in fields such as cancer vaccines and T-cell therapies. Tetramer Shop promotes the widespread application of high-performance MHC tetramers, enabling faster, more efficient, and cost-effective detection and monitoring of antigen-specific T cells. It has developed a series of tetramer products, including tetramers for screening T-cell epitopes associated with COVID-19.