Medtronic's Penditure™ Left Atrial Appendage Exclusion System Completes First Clinical Implantation in Mainland China

Introduction

China Builds the Stage, the World Sings in Harmony. Since 2018, the CIIE has been successfully held for eight consecutive sessions, becoming the premier launchpad for global new products, a preferred site for cutting-edge technologies, and a leading platform for innovative services. Thanks to the powerful spillover effects of the CIIE, numerous exhibits have accelerated their market entry, achieving rapid transformations from booth to shelf, farm to table, and concept to reality. The column "From Exhibits to Goods" documents, based on media reports, how high-quality global products promote high-quality development and create a better life at "CIIE speed."

On March 17, relying on the "Hong Kong and Macao Medicine and Medical Devices Access Policy" of the Guangdong-Hong Kong-Macao Greater Bay Area, Mr. Ma (pseudonym), a 54-year-old patient with atrial fibrillation in Guangdong, successfully received the implantation of Medtronic's Penditure at Guangdong Provincial People's Hospital.™Left Atrial Appendage Closure System (hereinafter referred to as the "System"). This marks the first clinical implantation of the system in mainland China, and represents a significant achievement by the Provincial Hospital in the field of globally advanced left atrial appendage closure surgical treatment technology.

Professor Guo Huiming, Deputy Director of the Department of Cardiovascular Surgery and Director of the Minimally Invasive Valve Center at the Provincial Hospital, introduced that atrial fibrillation (AF) is a common type of arrhythmia. Data shows that the number of AF patients in China has exceeded 20 million, and with the intensification of population aging, this figure is expected to continue to rise. AF can increase the risk of stroke by about five times, and in AF patients who experience thromboembolism, over 90% of blood clots originate from the left atrial appendage.

"Therefore, effective intervention on the left atrial appendage has become the key to stroke prevention in atrial fibrillation," said Professor Guo Huiming. In traditional surgical treatment, methods for handling the left atrial appendage include resection and suturing, stapler resection, epicardial ligation, or endocardial suturing. However, these methods often pose risks of bleeding or incomplete closure. To improve the success rate of left atrial appendage removal, many explorations have been carried out in the surgical field, leading to the development of left atrial appendage occlusion.

Compared with traditional left atrial appendage closure devices, Medtronic's Penditure™The Left Atrial Appendage Closure System is currently the world's only system that can be repeatedly deployed (i.e., retrieved, repositioned, and redeployed) during surgery, offering higher operational flexibility and precision. The device has received the CE mark and FDA approval. Professor Guo Huiming believes that the successful completion of the first clinical implantation in mainland China by Guangdong Provincial People’s Hospital marks the official entry of this globally innovative technology into real-world medical scenarios in mainland China.

In 2024, Medtronic Penditure™The Left Atrial Appendage Closure System made its debut at the 7th China International Import Expo and was officially approved in November 2025 through the "Hong Kong-Macao Drug and Medical Device Access" policy, creating favorable conditions for its clinical implementation in the Guangdong-Hong Kong-Macao Greater Bay Area.The Cardiovascular Disease Research Institute of Guangdong Provincial People's Hospital was the first to complete the implantation surgery of this system in mainland China, becoming a pioneer in the clinical implementation in China and providing high-standard treatment options synchronized with international standards for atrial fibrillation patients at high risk of stroke.

Original Title:First Case in Mainland China! Latest Left Atrial Appendage Closure System Lands at Provincial Hospital via "Hong Kong-Macao Medicine and Device Access"

Source:Guangzhou Daily New Flower City