SEIMEI Completes $4M Pre-A Financing to Advance Personalized Nutritional Anti-Aging Solutions

VCBeat has learned that SEIMEI, a high-end personalized nutrition and anti-aging technology brand, has announced the completion of its $4 million Pre-A financing round. The round was led by BlueFocus, with participation from ETP Zhihe Daokang Fund, Jiacheng Capital, and four high-net-worth individuals. The funds will be used for clinical studies, recruitment of senior scientific research and R&D talent, supply chain investment, and product marketing.

Over the past decade, the field of nutritional technology has advanced rapidly, yielding a substantial body of high-quality scientific research, particularly in areas such as gut microbiota and intestinal nutrition. Furthermore, the pandemic has heightened public awareness of leveraging nutrition to improve health. Nutrition should not be confined to the perioperative period; rather, it should be integrated reasonably and scientifically into daily life throughout one’s lifespan.

Meanwhile, driven by policy support and capital investment in recent years, the long-term, certain market demand and growth potential of the nutritional health market for middle-aged and elderly people have been recognized.

Taking the high-end nutritional anti-aging market targeted by Yisen Yimei as an example, there are currently approximately 400 million households in China, of which about 1% are high-net-worth households. The comfortable spending range for nutrition and health among these households averages around RMB 50,000–100,000, directly creating a market opportunity in China worth hundreds of billions of yuan. When including the global Chinese and Asian consumer demographics, the market size would expand by another threefold.

This high-net-worth demographic often bears multiple pressures from both their careers and families. From a demand perspective, they strive to maintain a state of “not getting sick” while “sustaining energy levels.” Most of their parents are over the age of 70 and frequently face various health issues, lacking access to scientific guidance. On the supply side, these individuals possess both the understanding and the ability to disseminate the scientific rationale behind health products.

However, in reality, technological innovations targeting the “new middle-aged” demographic aged 40–60 remain scarce. The market is highly fragmented and even chaotic, with the sector as a whole still in its early stages of development. This undoubtedly represents a significant opportunity gap for emerging brands.

Yan Zhao, Founder and CEO of Yisen Yimei, stated that the most critical factor in this industry is to build long-term product strength through scientific approaches—such as data-driven strategies, evidence-based medicine, and consumer research—while centering on consumers and establishing trust, alongside delivering high-quality services. The team at Yisen Yimei excels by leveraging rigorous evidence-based medical support and harnessing the power of AI to deliver digitalized, automated, and personalized services, thereby significantly improving labor efficiency.

It is reported that Yan Zhao graduated from the College of Chemistry and Molecular Engineering at Peking University. He previously served as a Technical Product Manager at Procter & Gamble’s Global R&D Center, and as Co-Founder and Co-President of Mininglamp Technology, an artificial intelligence enterprise. He possesses extensive experience in product development and team management. Moreover, the core team members of Senmei are entrepreneurial partners who once worked alongside Yan Zhao at Mininglamp Technology, sharing multiple layers of trust through connections such as Peking University alumni and Procter & Gamble alumni. The core scientific R&D team primarily hails from globally renowned food and nutrition science companies, including Nestlé and Danone.

From an individual’s perspective, to improve one’s health status through nutritional supplements, the first step is to choose the right products; secondly, it is essential to complement this with health monitoring data to track dynamic changes in indicators and make timely adjustments. Ideally, a dedicated service team should also be available to address any unresolved nutritional concerns. In response, Senmei has specifically developedProduct + Digitalization + Servicecomposite model.

Product Aspect, Senmei has partnered with the most authoritative experts and supply chains in the nutritional food sectors of China and Japan, ensuring comprehensive quality assurance from raw materials and formulations to production processes. Currently, Senmei has launchedONE Pro 3D Comprehensive Nutritional Supplement Powder, NMN Cellular Nutritional Supplement, and PB ONE ProbioticsThree products with innovative, multi-dimensional formulas that are delicious and meet the nutritional needs of middle-aged and elderly individuals.

Digitalization, Senmei has developed a mini-program for user health assessment that integrates users’ physical examination reports, hospital test results, and smart bracelet monitoring data, helping to form aScientific nutritional health plans and relatively comprehensive personal health data profiles. When users follow the nutritional plan provided by Yisen Yimei to consume its products, they can verify the changes brought about by the products through continuously updated health data.Combining data with experiential validation also helps further enhance user word-of-mouth and drive repeat purchases.

Service Aspect, Senmei is equipped withA professional “dual-specialist” service team comprising “nutritionists + counselors.”Consultants are responsible for addressing pre-sales and after-sales issues related to user products, while nutritionists provide lifestyle guidance once users obtain their health data, delivering personalized and targeted service experiences.

Currently, Senmei focuses onProduct Strength Development and WeChat Ecosystem Construction, match ONE Pro, the complete-nutrition minimalist product best suited to Chinese consumers, with users’ dietary characteristics to provide precise dosage recommendations. Meanwhile, integrate this with a user community engagement activation plan,Achieve viral growth through a model of high repurchase rates and word-of-mouth referrals.

Yan Zhao stated: "In the long term, once Senmei’s user base reaches a certain scale, we aim to leverage users’ health data to achieve"Personalization and Customization: Achieving “A Thousand Faces for a Thousand People”, leveraging data-driven insights to help users effectively manage their health data both within and outside healthcare institutions, thereby enabling precision nutrition. Meanwhile, we are buildingCompetitive Advantages of New Ingredients Based on Synthetic Biology. In the realm of digital health, it is hoped thatLeveraging DTx and real-world studies and experience from a large-scale user base to penetrate deeper into more serious medical scenarios.”

“Yisen Yimei’s Short-Term GoalsTo establish the leading brand in comprehensive anti-aging nutrition,“By leveraging scientifically evidence-based expert endorsements, celebrity spokespersons, brand ambassadors, and user testimonials, we aim to build consumer brand recognition and trust, thereby establishing ONE Pro’s professional image. Senmei NMN, on the other hand, offers ultimate cost-effectiveness under the premise of high quality, positioning it as the top choice for anti-aging enthusiasts and serving as the brand’s key traffic-driving product. Our overall goal is to achieve a market scale of 100,000 long-term users within the next three years,” said Yan Zhao.

Currently, Yisen Yimei has partnered with the most influential players in the gut health industryGut Institute, a global leader inLongevity Technology Company Human Longevity Inc. China Baijia Medical, A Globally Leading CROWuXi AppTec, a globally renowned user research firmIpsos Group, Silver Economy Think Tank PlatformAgeclub、Zeno Technology(Establishing the Senmeizheno Synthetic Biology Joint Laboratory) and other industry partners with significant influence have reached strategic cooperation.

Ms. He Lu, General Manager of the Investment Department at BlueFocus Capital, the lead investor in this round, stated“BlueFocus remains bullish on the big health sector and continues to strategically position itself within this track. We firmly believe that the big health and life sciences fields still hold immense development potential in the coming years, and we are confident in China’s ability to incubate world-class brands. As a technology company focused on precision nutrition and anti-aging, Senmei SEIMEI’s unique DTC model aligns perfectly with BlueFocus’s strategic layout of ‘Marketing + Sales.’ Under the ‘BlueFocus Model,’ the integration and synergy between marketing and sales—where marketing drives sales and sales reinforce marketing—can assist Senmei in better positioning itself in the ‘Marketing + Sales’ direction, thereby enhancing its service value. As a leading marketing agency with robust capabilities in technology, data, resources, and services, BlueFocus is committed to empowering Senmei SEIMEI in the realm of intelligent marketing. By providing valuable expertise in new media operations, reaching new users, and expanding new sales channels, we aim to drive Senmei SEIMEI’s commercial growth and support the brand’s long-term development.”

Dr. Liu Xiaoling, Partner at ETP Zhihe Daokang Fund, stated“Zhihe Daokang Fund has long been deeply engaged in the frontier technologies of precision medicine, having invested in more than 110 innovative healthcare enterprises across China and the United States. In this process, we have witnessed the rapid development of precision medicine and experienced the revolutionary changes it has brought to personalized healthcare. Similarly, as individuals differ in their physiological baselines, their nutritional supplementation needs also vary. We believe that emerging precision medicine technologies and digitalization will bring about a similar transformation to the development of nutritional supplements, making now the right time to actively engage in the field of precision nutrition. Yan Zhao, founder of Senmei, possesses successful entrepreneurial experience in the field of precision digitalization, and the founding team offers complementary expertise in digitalization and health foods. We are highly optimistic about his innovative practices in precision nutrition and look forward to close collaboration between Senmei and the numerous precision medicine companies already invested in by ETP Zhihe Daokang Fund, to create more personalized precision nutritional products and services with high medical technological content.”

Li Li, Founding Partner of Jiacheng Capital, stated“Jiacheng continues to focus on technological innovation in the life sciences and healthcare sectors. As a representative company in the field of precision nutrition, Senmei integrates interdisciplinary approaches such as nutrigenomics and metabolomics to launch precision nutrition products and solutions for diverse populations, including middle-aged and elderly individuals seeking anti-aging interventions, as well as patients with chronic diseases or cancer. As Senmei’s angel-round investor, Jiacheng values Senmei’s in-depth collaborations with leading medical institutions both domestically and internationally, major players in the nutritional technology industry, and scientists in the life sciences field. By focusing on new formulations and novel ingredients, Senmei is ushering in a new era of health science. Leveraging its multi-tiered ecosystem of innovators and scientists—including the Jiacheng Entrepreneurship Roundtable, Future Alliance, and NEXT Innovation Camp—Jiacheng will connect Senmei with scientific networks and industrial partners. Furthermore, through professional post-investment management, Jiacheng will support Senmei’s subsequent financing rounds, helping the company secure sufficient development capital during the current downturn in the venture capital industry.”