Yinghe Neuro Announces First Anniversary of Perceptual DBS Clinical Implantation, Ushering in a New Paradigm for Brain-Computer Interfaces

One year ago, the "Dual-Channel Rechargeable Implantable Deep Brain Stimulation System" independently developed by AMYGDALA NEURO successfully completed the implantation in the first batch of clinical pre-experiment subjects.

One year later, the follow-up data showed that: the symptoms of the subjects improved significantly and remained stable, and China-produced neuromodulation technology officially stepped into the "sensing era".

This is not only a success in clinical trials but also a milestone in the deep integration of AMYGDALA NEURO's self-developed technology with clinical practice applications, and perceptible technologies will gradually be applied to reality.

01 Stability: One-Year Follow-Up, the "Assurance" of Long-Term Efficacy

Professor Niu Chaoshi's team is performing DBS implantation surgery on the patient.

For patients with Parkinson's disease, DBS (Deep Brain Stimulation) surgery is not the endpoint, but the starting point of a high-quality life.

According to the clinical trial summary report, after the implantation of AMYGDALA NEURO's DBS system, the MDS-UPDRS III motor function score of the subjects decreased by 23.33±8.59 points from baseline under the condition of medication withdrawal and stimulation activation, showing a significant improvement. The PDQ-39 score, reflecting quality of life, dropped from 66 at baseline to 37.5, with a reduction of nearly 43%. Meanwhile, statistically significant improvements were observed in the Schwab and England scale, HAMD depression scale, and Parkinson’s Non-Motor Symptoms Scale (NMSS) scores, indicating a clinically meaningful enhancement in both motor function and quality of life for the patients.

It has been a year since the first patients were implanted.The patients' symptoms such as tremors and rigidity have achieved continuous and stable relief, not only ensuring a smooth postoperative transition but also improving their ability in daily life. This long-term stability verifies the outstanding quality of the AMYGDALA NEURO DBS system in electrode design, current distribution, and system reliability.

02 Intelligence: Decoding β Waves, Capturing the "Rhythm of Life" Deep in the Brain

The biggest difference between AMYGDALA NEURO's DBS system and traditional DBS lies in:It is no longer a simple "unidirectional blind discharge," but a treatment product with sensing capabilities and directional stimulation.And the subjects received MRI scans in both the on and off states of the device, which showed stable operation and good imaging performance.

Abnormal synchronization of β waves in the brain functional regions of Parkinson's disease patients is considered a key biomarker of motor disorders.In this clinical trial, local field potential (LFP) signals of the STN nucleus were collected, and by analyzing changes in the intensity of beta waves, "brain signals" related to movement disorders were captured in real time. This sensing capability lays the foundation for future closed-loop regulation, shifting treatment from a "one-size-fits-all" approach to individualized precision programming that adapts to the timing and needs of each patient.

EEG Signal Acquisition FFT Calculation Results

03 Innovation: Driven by Hardcore Technology, Breaking Overseas Technical Barriers

The success of AMYGDALA NEURO's DBS system is attributed to several industry-leading technological breakthroughs:

More Precise:Innovative Directional Electrodes: A single lead integrates 2 omnidirectional contacts and 6 directional contacts, allowing for free combination of stimulation directions, effectively reducing side effects caused by traditional ring electrodes. Each stimulation contact can be independently parameterized for output.

More Compact:The implantable pulse generator (IPG) is approximately 20% smaller in volume compared to similar products, enhancing patient comfort after implantation.

More Compatible:The entire system supports 3.0T superconducting MRI scans, breaking the limitations of postoperative imaging monitoring and eliminating patients' concerns for follow-up medical care.

AMYGDALA NEURO Dual-Channel Rechargeable Implantable Deep Brain Stimulation System

04 Far: Racing Towards the Brain-Computer Interface Trend, Empowering the Future of Brain Science

Brain-computer interface is at the forefront of human exploration of the mysteries of the brain.AMYGDALA NEURO is not only dedicated to the treatment of Parkinson's disease but also extends its technology to a broader range of neuropsychiatric disorders, such as dystonia, epilepsy, obsessive-compulsive disorder, and depression, by building two major platforms: "Generalized Neuromodulation" and "Brain-Computer Interface."

As Professor Niu Chaoshi, the principal investigator of this clinical trial from the First Affiliated Hospital of the University of Science and Technology of China, stated: "This product integrates directional electrodes with sensing functionality, offering a more comprehensive and refined solution for complex cases and the realization of closed-loop systems."

Conclusion

From the lab to the operating room, AMYGDALA NEURO is leveraging its hardcore R&D capabilities to transition "Made in China" from "substitution" to "leadership."In the future, AMYGDALA NEURO will continue to deepen its research in brain-computer interface technology, using the power of science and technology to light up the hope of life for tens of millions of patients with nervous system diseases.

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