Shanghai-based Chao Weijing Biotech Launches China's First In Vivo Two-Photon Microscopy System for Clinical Dermatology Applications

Two-Photon Microscopy Imaging TechnologyAs one of the most important imaging techniques in the field of biology, it not only provides morphological information but also spectral information, which holds significant potential application value for clinical auxiliary diagnosis, evaluation of early-to-mid-term efficacy in medical aesthetics, and assessment of skincare product efficacy. However, the imaging components currently used in two-photon microscopy are bulky and poorly designed from an ergonomic perspective, limiting the examination sites in clinical applications. Furthermore, the complex and precise internal optical path structure results in poor stability and reliability.

Based on this, Academician Cheng Heping of Peking University and his team have developed an in vivo two-photon microscopy imaging system after years of technological breakthroughs. This development isFirst Application of Interdisciplinary Brain Science Technology to Assist in Skin Detection, introducing the most advanced two-photon microscopy imaging technology into the field of modern dermatological diagnostics, achieving “Real-time, Non-invasive, In vivo, In situ, Label-free” high-resolution 3D imaging of skin cells and extracellular tissue, bringing convenience to patients and physicians.

The in vivo two-photon microscopy imaging system was approved for market launch in December 2023, and isChina's First Medical Device Based on Two-Photon Microscopy Imaging Principle。

On Wednesday, January 31, at 19:30, the 43rd session of VCBeat Select New Product Review will feature Lin Feng, Product Director of the Product Division at TRANSCEND VIVOSCOPE, and Dr. Wang Junjie, Assistant Researcher at the School of Future Technology, Peking University, who will presentChina's First In Vivo Two-PhotonProduct Promotion.

Figure: TRANSCEND VIVOSCOPE In Vivo Two-Photon Microscopy Imaging System

Technical Specifications:

Excitation Wavelength: 780±10 nm

Horizontal resolution: ≤ 0.8 μm

Scanning Field of View: ≥125 μm x 125 μm

Imaging Depth: ≥200 μm

Imaging Frame Rate: >8 fps

Imaging Channel: 420–580 nm (AF Channel)

375–410 nm (SHG channel)

In vivo two-photon microscopy imaging system is used for epithelial cells and tissues of the body surface skinHigh-Resolution 3D Layered Scanning Imagingan innovative medical imaging device.

The instrument itself consists ofHostandHandleIt consists of two parts: the main unit and the handle, which are connected by a flexible optoelectronic composite cable.Easy to GripThe ergonomic handle design enables operators to quickly examine various parts of the subject's body. The entire unit weighs only13kg. This instrument facilitates the identification of tissue components and assists in assessing metabolic function, thereby providing a new paradigm for multimodal imaging in dermatological clinical practice and scientific research.It provides a convenient option for researchers, physicians, and professionals in the beauty and cosmetics industry who are engaged in skin-related work.

Highly Integrated, Suitable for Multiple Application Scenarios

Handheld probe, suitable for all body surface areas

By leveraging the principle of two-photon excitation, it is possible to achieveIn vivo, in situ, non-invasive, label-freereal-time imaging.

Optical sectioning thickness as thin as 2 μm

Clearly Visualize Cellular and Extracellular Matrix Morphology

Two-Photon Excitation Fluorescence (TPEF) ——NAD(P)H/FAD, pigment granules, elastic fibers, keratin, etc.

Second Harmonic Generation (SHG) — Collagen Fibers

1. Auxiliary Diagnosis of Skin Diseases

2. Clinical Basic Research

3. Evaluation of Aesthetic Medicine Efficacy and Cosmetic Effectiveness

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Lin Feng

Product Director, Medical Products Division, TRANSCEND VIVOSCOPE

Previously held positions at multinational corporations such as GE Healthcare and NVIDIA, with over ten years of experience in the medical industry within foreign enterprises.

Earned bachelor’s and master’s degrees from Beihang University.

Primarily engaged in the R&D, registration, and quality management of medical imaging equipment, as well as the productization and commercialization of innovative medical devices.

Dr. Wang Junjie

Assistant Researcher, Peking University

Primarily engaged in research on biomedical imaging technologies. Successfully developed the world’s first two-photon microscope for space stations, which has been successfully operated in orbit on the Chinese Space Station. Concurrently, the in vivo two-photon microscopic imaging system developed by the team was approved as China’s first Class II innovative medical device based on the principle of two-photon imaging, marking a key breakthrough in transitioning two-photon microscopy from laboratory platforms to in vivo biomedical monitoring.

For years, TRANSCEND VIVOSCOPE has been committed to becoming a global leader in the field of biomedical imaging, providing high-quality, systematic solutions to advance research and development in the life sciences. Through cutting-edge technologies and active collaborations with academic institutions both in China and abroad, we jointly promote the high-quality development of global brain science research.

Looking ahead, TRANSCEND VIVOSCOPE will innovate life sciences technologies and create a better life under its brand philosophy of “Better Technology, Better Life.”

“VCBeat Select New Product Launch” is a live-streaming series under the “VCBeat Select” brand, dedicated to supporting medical enterprises in launching innovative products. The program’s mission is to empower every milestone launch of innovative medical products.

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