ManShu Medical, Founded by Experts from Tier-3 Hospitals, Files IPO Prospectus with Integrated 'Hospital Treatment, Home Rehabilitation' Solution for Chronic Wound Care

Data released by the National Bureau of Statistics show that,2023In [year], China's elderly population and aging level increased to2.97Yirenhe21.1%, the rapid aging of the population has ushered in a moderately aged society.

Moreover, as noted by the National Health Commission in the “14th Five-Year Plan for Healthy Aging,” “more than 78% of older adults suffer from at least one chronic disease.” This results in substantial and prolonged demand for medical resources, driving up healthcare costs, placing greater pressure on social security systems and the allocation and utilization of medical resources, and consequently increasing the demand for nursing care personnel.

However, as the population ages further, consumption patterns are shifting accordingly. The healthcare and related industries are facing new market opportunities, with medical and health services extending into the home setting. Medical devices designed for home use are gradually helping to alleviate the pressures brought about by an aging society.

Against this backdrop, Changzhou Mansoul Medical Technology Co., LTD (hereinafter referred to as “Mansoul Medical”), an innovative enterprise dedicated to the research and development, manufacturing, and sales of wound care devices and consumables under the philosophy of “hospital-based treatment and home-based rehabilitation,” was officially established in 2021.

Changzhou Mansoul Medical Technology Co., LTD’s self-developed portable negative pressure wound therapy (NPWT) device and biological dressings can significantly accelerate wound healing and improve healing quality, while minimizing the risk of complications. This innovation introduces a new paradigm for modern home-based wound care management, particularly for chronic and complex wounds prevalent in the elderly, such as diabetic foot ulcers, pressure injuries, and arterial or venous ulcers.

Taking diabetic foot as an example, elderly patients with diabetes constitute the primary population affected by diabetic foot in China. They often present with more severe lesions and face higher rates of disability and mortality. Diabetic foot causes significant suffering and economic loss to patients and their families, while also imposing a heavy burden on the healthcare system and society at large.

Given the enormous population of diabetic patients in China, the protracted treatment and rehabilitation process cannot rely solely on medical staff at diabetic foot care centers and primary healthcare institutions. Furthermore, improper out-of-hospital care can compromise the efficacy of in-hospital treatment and exacerbate the condition. Therefore, experts have pointed out that home-based care for diabetic foot represents the most advantageous model for managing this condition under China’s current healthcare system and resource allocation.

Driven by clinical demand, negative pressure wound therapy (NPWT) offers significant benefits, including enhanced local perfusion, promotion of granulation tissue growth, and acceleration of wound healing. The “Expert Consensus on the Application of Vacuum Sealing Drainage Technology in the Treatment of Diabetic Foot Wounds” also points out that the use of NPWT for diabetic foot wounds can significantly improve wound healing rates, shorten healing time, and reduce amputation rates. Undoubtedly, NPWT has become an important adjunctive therapy in the management of diabetic foot wounds.

In this regard,Zhang Ye, General Manager of Mansoul MedicalIt was introduced that conventional negative pressure therapy devices generally consist of tabletop units placed beside the hospital bed and medical central suction systems fixed at the patient’s bedside. Both options only support treatment while the patient remains in a hospital bed or within the hospital, significantly limiting their application scenarios. Furthermore, medical central suction systems face challenges in precisely regulating negative pressure values, which compromises the precision and efficacy of wound care.

Portable Negative Pressure Wound Therapy Device

Compared with traditional methods, Mansoul Medical’s portable negative pressure wound therapy device not only provides patients’ wounds with continuous, constant, and adjustable negative pressure, but also features a smaller size, lighter weight, and lower cost.Specifically, this portable negative pressure wound therapy device offers the following key advantages.

First, traditional wound care requires frequent dressing changes by medical staff and prolonged hospitalization. In contrast, Changzhou Mansoul Medical Technology’s portable negative pressure wound therapy device features an integrated drainage bottle that allows for self-replacement of the collection canister, thereby reducing the workload on healthcare professionals. Furthermore, with a footprint no larger than a palm, the device is highly portable, enabling patients to receive treatment conveniently across various settings and environments.

Especially for patients with chronic wounds requiring long-term care, portable devices have enabled a home-based model of wound management, allowing patients to receive continuous negative pressure wound therapy. With a single charge lasting over 30 hours, these devices continuously remove exudate and infectious materials while maintaining a moist healing environment, thereby accelerating the migration and proliferation of skin tissue cells at the wound site.

Secondly, by improving system algorithms, Changzhou Mansoul Medical Technology Co., LTD has controlled the negative pressure adjustment accuracy within ±0.5 mmHg, whereas traditional medical central suction systems typically operate at around ±5 mmHg. Through a refined negative pressure wound care model, the device precisely maintains negative pressure within the clinically required range, thereby improving wound healing outcomes. Furthermore, the negative pressure settings can be further customized and adjusted according to physicians’ requirements based on the specific conditions of individual patients.

As a portable, reusable medical device, Mansoul Medical has enhanced equipment safety through system design to simplify hospital cleaning and disinfection procedures.On one hand, the polyvinyl alcohol dressings, sterile adhesive dressings, catheter fixation devices, and collection canisters used in portable negative pressure wound therapy (NPWT) devices are all single-use disposables, ensuring that the NPWT pump itself does not come into contact with drainage fluids. On the other hand, the company’s R&D team has designed a dual-protection system featuring check valves and reverse osmosis membranes to prevent contamination risks between the pump and the collection canister.

Of course, Mansoul Medical’s portable negative pressure wound therapy device is not only suitable for complex and refractory diabetic foot ulcers, but also applicable to various surgical wounds, traumatic wounds, and acute or chronic wounds, such as surgical incisions, burns and scalds, skin graft sites, pressure ulcers, and venous leg ulcers.

Demonstration of Portable Negative Pressure Wound Therapy Device Operation

“Portable negative pressure wound therapy devices are just one component of Mansoul Medical’s comprehensive wound management solution. The company aims to provide end-to-end solutions spanning hospital, community, and home settings for post-surgical wound care and complex chronic wounds, covering the entire lifecycle of wound diagnosis, assessment, repair, and prevention,” said Zhang Ye.

One of the simplest methods to assess wound progression or deterioration is to measure wound dimensions, area, and volume. Chronic wounds, such as diabetic foot ulcers, require regular re-evaluation and adjustment of treatment plans. This process often relies on healthcare professionals with extensive clinical experience to perform visual inspections and use auxiliary tools for comparative observation and measurement, which is both time-consuming and costly.

In response, to improve the accuracy and efficiency of wound diagnostic assessment, Changzhou Mansoul Medical Technology Co., LTD has developed an Intelligent Wound Diagnostic Device based on digital technology and artificial intelligence. By leveraging high-precision optical imaging technology alongside deep learning and AI-assisted systems, the device helps physicians conduct precise wound assessments and achieve efficient wound data management.

Specifically, the device assesses wound infection status by detecting the fluorescence of wound microbes. It also records blood flow at the wound site using infrared thermal imaging and performs automated, intelligent wound classification, assessment, and measurement based on comprehensive indicators such as inflammatory factors. This innovation fills a gap in the industry for intelligent wound management, assists physicians in improving clinical care, and ultimately alleviates patient suffering.

“Since its establishment over three years ago, the company has closely aligned with clinical needs and adhered to clinical standards, proposing multiple innovative solutions for comprehensive wound management. Currently, its portable negative pressure wound therapy (NPWT) devices and associated consumables, as well as silicone gel foam dressings, have received regulatory approval and are commercially available. The smart wound diagnostic device is nearing completion of its prototype manufacturing. In addition, the company has one Class III, one Class II, and four Class I medical device products under development. These achievements are inseparable from the dedication and deep expertise of our core team,” said Zhang Ye.

According to reports, Mansoul Medical was co-founded by experts from tertiary hospitals and engineering technicians.On one hand, the company addresses various technical, methodological, and equipment-related challenges in clinical wound management through interdisciplinary collaboration between medicine and engineering, thereby improving healthcare quality and efficiency as well as patients’ quality of life. On the other hand, these innovative achievements—including new technologies, products, and methodologies—will further drive progress in the wound management industry and foster a virtuous innovation ecosystem integrating medicine and engineering.

As an innovative medical device enterprise in Changzhou, Mansoul Medical is located in the China-Israel Changzhou Innovation Park and has established in-depth collaborations with the park and its enterprises.. The China-Israel Changzhou Innovation Park is the first innovation demonstration park jointly established by the governments of China and Israel through a bilateral agreement, aiming to promote innovative cooperation in industry, technology, and talent between the two countries.

Zhang Ye explained, “Mansoul Medical primarily focuses on the research and development of active medical devices, whereas Israel has achieved numerous innovations in the field of high-value consumables. Through collaborations with Israeli research institutions and enterprises, the company has not only further expanded its product portfolio but also laid a foundation for consolidating and enhancing its global competitiveness.”

At the end of the interview, Zhang Ye continued, “In the future, Mansoul Medical will continue to deepen its engagement in the research and development, manufacturing, and sales of wound care devices and consumables, continuously enhancing product innovation, reputation, and brand influence. Currently, the company is also building its own official mobile sales platform, aiming to deliver portable and intelligent wound care products to patients across China and around the world through a more efficient, convenient, and precise direct-sales model, thereby promoting the concept of ‘hospital-based treatment and home-based rehabilitation.’”