Hydrogen-Oxygen Biomedicine Unlocks a Billion-Dollar Blue Ocean: Liedian Medical Builds a Diversified Supply Chain to Lead Market Entry

Hydrogen, a once-overlooked gas, is now gradually emerging in the field of biomedicine.

As early as 1776, the British scientist Henry Cavendish first identified and described hydrogen as a distinct substance. His discovery was not only a milestone in the history of chemistry but also laid the foundation for the extensive application of hydrogen in the fields of energy, chemical engineering, and medical aesthetics. However, it was not until 2007, when Japanese scientist Shigeo Ohta and colleagues published an article in *Nature Medicine* reporting that exogenous hydrogen could selectively scavenge hydroxyl radicals and peroxynitrite anions, thereby alleviating oxidative damage caused by middle cerebral artery ischemia-reperfusion in rats, that the physiological regulatory activity and signal transduction functions of hydrogen gained recognition, and hydrogen medicine officially entered the public eye.

According to relevant statistical data, as of August 24, 2019, the National Natural Science Foundation of China (NSFC) had funded 85 projects related to the biological functions of hydrogen, distributed across 42 research institutions. In January 2019, Shanghai Jiao Tong University took the lead in establishing the Hydrogen Science Center, directed by Academician Ding Wenjiang. The center focuses on supporting research in hydrogen energy and hydrogen biology, and has garnered significant attention from the Ministry of Science and Technology of China, the Shanghai Municipal Science and Technology Commission, as well as domestic and international peer experts, marking a milestone in this field. Furthermore, to date, more than 2,000 academic papers related to hydrogen medicine have been published, with the number increasing year by year.

Nowadays, numerous studies have demonstrated that hydrogen gas possesses antioxidant, anti-inflammatory, and anti-apoptotic properties. It exerts significantly beneficial effects on ischemia/reperfusion injury, inflammation-based acute tissue ischemic diseases, and chronic degenerative disorders associated with oxidative stress, such as Parkinson’s disease, Alzheimer’s disease, and atherosclerosis. Hydrogen molecules can be administered through methods including hydrogen inhalation, consumption of hydrogen-rich water, and hydrogen baths, thereby facilitating preventive healthcare and enhancing overall health status.

Medical Value of Hydrogen Molecules

Lidian Medical Mapping

With the deepening of domestic biomedical research on hydrogen-oxygen and the continuous expansion of its clinical applications, the hydrogen-oxygen health industry has gradually emerged. In March 2020, the official website of China's National Health Commission released the "Seventh Edition of the Diagnosis and Treatment Protocol for COVID-19," which formally included hydrogen-oxygen therapy as a treatment modality, marking the recognition of hydrogen's therapeutic efficacy in pneumonia. Meanwhile, relevant data indicate that by 2025, the scale of China's hydrogen health industry will exceed RMB 30 billion, becoming an important component of the broader health and wellness sector.

Meanwhile, as the aging trend in Chinese society continues to intensify, health has undoubtedly become the most critical demand. Against this backdrop, Guangdong Lidian Medical Technology Co., Ltd. (hereinafter referred to as “Lidian Medical”) conducted extensive research and field studies in Japan, a country that ranks among the highest globally in terms of population aging yet possesses rich experience in addressing this challenge. Through these efforts, the company gained access to hydrogen-oxygen medicine, which is widely popular locally. Leveraging its years of deep expertise in the broader health industry and its cutting-edge innovative technological capabilities, Lidian Medical has established a diversified supply chain, taking an early lead in the field of hydrogen-oxygen biomedicine.

Looking back on the history of hydrogen-oxygen biomedicine, American scholars Dole et al. first reported in 1975 in Science magazine that high-pressure hydrogen gas improved skin cancer in mice. Later, Ohta Shigeo proposed in Nature Medicine that hydrogen exerts its therapeutic antioxidant effects by selectively reducing cytotoxic oxygen free radicals.

Currently, organisms ingest H₂There are three main routes: gaseous, liquid, and solid. Typically, H₂Sources include canned hydrogen, water electrolysis, and chemical preparation, with water electrolysis being the mainstream technology for hydrogen production in biological applications. Among these, the gaseous hydrogen delivery route is primarily through H₂Inhalation; liquid hydrogen delivery primarily involves the use of (hydrogen-rich) water, with administration methods including oral ingestion, injection, and whole-body or local immersion; solid hydrogen delivery methods include oral administration to promote intestinal bacterial metabolism for H₂ production.₂nutrients, etc.

In this regard, Guangdong Lidian Medical Technology Co., Ltd. has mastered the core technologies for hydrogen electrolyzer development, as well as proprietary electronic control technologies for hydrogen-oxygen equipment. In terms of water electrolysis technology, the company employs pure-water hydrogen-oxygen separation technology to ensure product purity, thereby safeguarding public health. Furthermore, the company has mastered SPE (Solid Polymer Electrolyte) hydrogen-oxygen separation electrolysis technology, which enables highly efficient electrolysis and ensures hydrogen purity of up to 99.99%.

It is reported that Lidian Medical has successfully developed and manufactured a series of hydrogen-oxygen products, including hydrogen-oxygen inhalers, hydrogen-rich water dispensers, hydrogen-rich water cups, hydrogen beauty devices, and hydrogen bath machines. Among these, the hydrogen-oxygen inhaler utilizes advanced PEM (Proton Exchange Membrane) water electrolysis technology to decompose water into hydrogen and oxygen. The hydrogen-rich water dispenser relies on PEM ion exchange membranes, supplemented by iridium solid-state electrolytes, to ensure efficient separation of hydrogen and oxygen. The hydrogen-rich water cup employs electrolytic chip technology to generate hydrogen ions through electrolysis, allowing hydrogen molecules to be uniformly dissolved in water for a stable combination of hydrogen and water. Similarly, the hydrogen bath machine is based on PEM ion exchange membranes, achieving hydrogen-oxygen separation through electrolysis to ensure an appropriate concentration of hydrogen molecules in the bathwater.

This year, the company launched its first hydrogen-oxygen respirator, which has obtained multiple national patents. The device boasts a service life of over 30,000 hours and features a lifetime maintenance-free water system, an automatic water filling and draining system, a TDS water quality detection system, an intelligent timing system, and an AI voice alarm alert system. The hydrogen concentration can reach up to approximately 80%.

According to Lidian Medical, since its launch in the domestic market, the product has not only garnered widespread acclaim from distributors but also attracted significant attention from overseas clients in regions such as Russia and Japan.

“Lidian Medical’s independently developed products offer advantages such as high-purity hydrogen, ample flow rate, long service life, stable performance, ease of operation, high safety, and comprehensive services. In addition, the ‘Luobang Shangpin’ series of hydrogen-oxygen products are portable and mobile, making them particularly suitable for elderly users. We also support customized solutions tailored to specific needs, proactively addressing potential concerns from partners or end consumers at the upstream stage, which has enabled our products to stand out in the market. Most importantly, an increasing number of doctors and medical professors have professionally recognized our efforts,” the founding team of Lidian Medical told VCBeat.

To further enhance its R&D, production, and sales capabilities, Lidian Medical has demonstrated the advantages of its diversified layout in the supply chain. The company not only boasts a robust R&D and scientific research team and has established talent partnerships with pharmaceutical universities such as Guangdong Pharmaceutical University, but also maintains close collaborations with hospitals, community clinics, pharmacies, elderly care centers, postpartum care centers, and medical aesthetic institutions across China, setting up experience-based sales outlets in all these product usage scenarios. This diversified supply chain resource provides profound self-driven momentum for the educational popularization and market promotion of the company’s products.

As a distinctive medical device enterprise in the Greater Bay Area integrating industry, academia, and research, Lidian Medical made its debut on multiple national and provincial media platforms—including CCTV, Jiangsu Satellite TV, Hunan Satellite TV, and Guangdong Satellite TV—as early as 2022. The company has subsequently been recognized in batches as a “Guangdong Province Quality-Focused and Credibility-Respected” enterprise and as a member unit of the “Guangdong Medical Device Industry Association.” Its proprietary brand, “Luobang Shangpin,” is dedicated to providing solutions for respiratory health and sub-health conditions. Leveraging diversified supply chain and industry-academia-research resources, the company has also assembled an expert team comprising more than twenty medical consultants at the level of associate chief physicians, providing robust support for its integrated industry-academia-research model.

Notably, in May 2023, Lidian Medical formally entered into a long-term strategic partnership with Zhejiang Longfei Medical Instrument Co., Ltd., a well-established and renowned domestic oxygen concentrator manufacturer. Under this collaboration, Lidian Medical’s proprietary brand “Luobang Shangpin” was designated as a co-developed sub-brand for the Chinese market. Through resource integration and mutual empowerment, the partnership aims to expand Lidian Medical’s distribution network beyond the Greater Bay Area to achieve nationwide coverage across China. Meanwhile, it will also accelerate the global promotion of Longfei Medical’s oxygen therapy product series and deepen its industrial layout.

As hydrogen-oxygen medicine continues to develop and its applications expand, Guangdong Lidian Medical Technology Co., Ltd. is leveraging its technological expertise, innovative product capabilities, and diversified supply chain layout to further enhance product competitiveness and drive technological advancement in the field. Currently, Lidian Medical is actively pursuing medical device registrations and certifications for its products, striving to achieve national recognition and enable widespread adoption. “For any emerging innovation to truly enter the market, a process of dispelling misconceptions is essential,” stated the founder of Lidian Medical.

Looking ahead, Lidian Medical will remain steadfast in its original mission of “continuously creating value for target customers.” By keeping pace with the times, keenly observing market shifts, and leveraging technological innovation as its core engine, the company will build its competitive advantages. Through continuous product R&D and iteration, as well as service optimization, Lidian Medical is committed to delivering superior value experiences to China’s healthcare industry.