Origin Medtech Launches World’s First Self-Developed Biodegradable Magnesium Vascular Clip – BaiYouMei®

Addressing the urgent clinical need for “intervention without implantation, and implantation without residue,”Biodegradable Materialshas become a hot topic in biomaterials research,In recent years,Biodegradable Medical-Grade Magnesium Alloy Materialsresearch and clinical applications have garnered widespread attention.

In the field of medical implant metal materials, stainless steel, titanium alloys, cobalt-chromium alloys, nickel-titanium alloys, and others are widely used due to their favorable mechanical properties, biological inertness, corrosion resistance, and overall structural stability. However, for numerous application scenarios where the implant is no longer needed after the therapeutic function has been fulfilled, these metallic materialsInability to Achieve In Vivo Degradation and Biological Integration, necessitating a second surgical procedure for removal. The resulting secondary trauma causes significant suffering for many patients, or the device remains permanently in the body, posing risks associated with foreign bodies. Meanwhile, although polymeric materials currently used in clinical practice, such as polylactic acid (PLA), are biodegradable and absorbable in vivo, their widespread market acceptance is limited due to issues including low mechanical strength and inflammation induced by acidic degradation products.

Magnesium is an essential macroelement for the human body. During its degradation process, magnesium ions, hydroxide ions, and hydrogen gas are produced, all of which are beneficial to the human body. Therefore, since 2000,In the global field of biomedical materials, biodegradable metallic magnesium has garnered significant attention and is hailed as a “transformative medical metal material.”

Dr. Zhang Xiaonong, founder of Origin Medtech, and his team have been engaged in research since 2002 onBiodegradable Magnesium Metalconducted fundamental research and founded Origin Medtech in 2010,Relying on a self-built, domestically leading technology platform for degradable magnesium metal materials, to explore this material inMinimally Invasive Surgery, Orthopedic Sports Medicine, Medical Aesthetics, and Interventional Medicineclinical practical application. Developed by Origin Medtech“"Biodegradable Magnesium Metal Closure Clip"Completed in December 2023Obtained the Class III medical device registration certificate from China's National Medical Products Administration (NMPA), filling the previous domestic gap in this field,It is expected to significantly increase the clinical benefits for patients.

On Tuesday, July 23, at 19:30, the 78th edition of VCBeat Select New Product Review will feature Dr. Zhang Xiaonong, CEO of Origin Medtech, and Mr. Li Hailong, Product Manager at Origin Medtech, who will present “"The World's First Independently Developed Biodegradable Magnesium Metal Closure Clip—Baiyoumei®"Product Introduction.

Biodegradable Magnesium Metal Hemostatic Clip (Magnesium Clip)Composed of biodegradable magnesium metal clips and a base.Magnesium ClipIt consists of three parts: the upper arm, lower arm, and tail O-shaped structure, which are placed within the base.

Magnesium clips are usedHigh-Purity Magnesium Materialsmanufactured to effectively avoid the potential health risks associated with elements commonly used in existing industrial magnesium alloy products, such as aluminum and rare earth elements. After being surgically implanted into the patient's body, based onDifferences in Small, Medium, and Large Specifications and Models，Magnesium ClipIt can be fully degraded in the human body within approximately six months to one year.，Furthermore, post-implantation does not interfere with postoperative imaging diagnostics such as CT and MRI.. Meanwhile, based on biodegradable magnesium metal materialsGood mechanical compatibility, physical compatibility, and biocompatibility, and magnesium inAnti-inflammatory, Anti-tumorGiven its superior potential in this regard, magnesium clips hold significant clinical value.

This product is indicated for the ligation and closure of tubular tissues, such as blood vessels or bile ducts, that do not require permanent closing force during surgical procedures. It is not suitable for use in major arteries and veins.The launch of this product will provide more and better options for clinical treatment.

Including but not limited to the following scope:

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Zhang Xiaonong

CEO of Origin Medtech

Since 2003, I have been engaged in exploratory research on materials and devices based on nutrient-element-containing biodegradable magnesium alloys for biomedical applications. I have published more than 100 papers as first or corresponding author (with over 6,000 citations) and obtained more than 80 authorized patents. Related achievements have led to the establishment of Origin Medtech to conduct product translation research.

Its independently developed biodegradable absorbable magnesium alloy closure clip was recognized as an innovative medical device by the National Medical Products Administration (NMPA) in 2018 and has currently obtained a Class III medical device registration certificate (No. 20233021931). It is the first medically approved magnesium metal implant device in China and the world’s first biodegradable magnesium metal closure clip, demonstrating the company’s leading position in research within this field.

Li Hailong

Product Manager at Origin Medtech

Graduated with a degree in Clinical Medicine from Tongji University, previously served at multiple hospitals in Shanghai, primarily engaged in surgical medical practice. Later transitioned to the medical device industry, participating in the research and development as well as clinical application of products across multiple specialties. Possesses extensive experience in promotion within the fields of medicine and medical devices.

The company is located in the Changshu Economic and Technological Development Zone in Suzhou, Jiangsu Province. Established in June 2010 as a high-tech startup, it is dedicated to the innovation and industrialization of novel biodegradable and absorbable metallic materials and their related medical devices.

The company’s technical team hails from Shanghai Jiao Tong University and brings over 20 years of R&D expertise in medical-grade metallic materials. Medical magnesium alloys, hailed as “revolutionary metallic biomaterials,” have demonstrated clinical feasibility internationally and are poised to replace traditional medical materials, emerging as a star player in the field of bioresorbable medical devices.

The company holds nearly 80 invention patents, utility model patents, design patents, and international PCT patents. Its globally first magnesium-metal surgical medical device has been approved by the National Medical Products Administration (NMPA) and is now fully commercialized, maintaining a leading position in China. The biodegradable magnesium metal closure clip is the first approved metallic biodegradable material in China; it was recognized as an Innovative Medical Device as early as 2018 and is the 245th innovative medical device approved by the state.

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