Yaguo Technology Files IPO Prospectus for China's First Combined Diaphragm-Abdominal Neuromuscular Stimulator: Respiratory Neuromuscular Stimulator

Respiration is primarily achieved through the contraction and relaxation of respiratory muscles, facilitating the processes of inhalation and exhalation. Among these muscles, the diaphragm and abdominal muscles are the most critical components. As the primary muscle of respiration, the diaphragm’s contraction and relaxation directly determine changes in thoracic volume, thereby influencing pulmonary ventilation. Meanwhile, the abdominal muscles also play a vital role during breathing; they work in synergy with the diaphragm to ensure that each breath is efficient and unobstructed. Therefore, gaining a deep understanding of the significant roles played by the diaphragm and abdominal muscles in respiration is of great importance for elucidating the operational mechanisms of the respiratory system and promoting respiratory health.

Respiratory Neuromuscular Stimulator is a therapeutic device that can effectively improve pulmonary ventilation function and promote respiratory rehabilitation. By employing electrophysiological technology, it delivers coordinated feedback electrical stimulation to the phrenic nerves and abdominal muscles through six pairs of external electrodes, inducing rhythmic contractions of the diaphragm and abdominal muscles, increasing tidal volume, and promoting the expulsion of CO₂ from the alveoli.₂Facilitate secretion clearance, alleviate dyspnea, enhance respiratory muscle strength and endurance, and promote pulmonary rehabilitation in patients.

Since its launch, Yaguo Technology’s respiratory neuromuscular stimulator has been widely acclaimed and supported in clinical practice due to its significant efficacy, with a coverage rate exceeding that of the Top 100 hospitals in China.80%, including the Chinese PLA General Hospital, Beijing Tiantan Hospital, the First Affiliated Hospital of Zhengzhou University, Shanghai Zhongshan Hospital, the Third Affiliated Hospital of Sun Yat-sen University, and the First Affiliated Hospital of Chongqing Medical University, with installations in hundreds of hospitals. Meanwhile, it has been exported to Europe10Multiple Countries, Global30Spanning multiple countries across Asia, Europe, Oceania, and Latin America.

8June 6 (Tuesday) at 19:30, VCBeat New Product Review Session No. 82, featuringLi Qian, Founder and General Manager of Yaguo Technology; Li Fengying, Sales Manager of Yaguo Technology; Song Kai, Sales Director for South China at Yaguo TechnologyProduct Introduction by Beijing Yaguo Technology Co., Ltd.

Respiratory Neuromuscular Stimulator Synchronizes Patient Breathing via Audio-Visual Feedback.

Respiratory Muscle Dysfunction Caused by Multiple Etiologies (Manifested as Dyspnea, Reduced Diaphragmatic/Abdominal Muscle Strength, Ineffective Cough and Sputum Clearance, Difficulty in Weaning and Extubation, Gastroesophageal Reflux, etc.)

Department of Respiratory Medicine:Chronic Obstructive Pulmonary Disease (COPD), Bronchial Asthma, Interstitial Lung Disease, Pulmonary Hypertension, Acute Respiratory Distress Syndrome (ARDS), Respiratory Failure;

ICU：Ventilator-induced diaphragmatic dysfunction (VIDD), ICU-acquired weakness (ICU-AW);

Rehabilitation Department:Stroke, brain and spinal cord injuries, trauma, tumors, intractable hiccups, neuromuscular diseases (such as ALS);

Department of General Surgery:Enhanced Recovery After Surgery (ERAS); cardiothoracic and abdominal surgery (preoperative/postoperative);

Cardiology Department:Cor pulmonale, chronic heart failure;

Oncology Department:lung cancer, etc.

Biphasic electrical stimulation of the phrenic nerve and abdominal muscles allows for independent selection of either the diaphragm or abdominal muscle therapy channel.

Personalized respiratory parameter settings with dual auditory and visual feedback, synchronized with spontaneous breathing for greater comfort and efficiency.

Treatment Data Record Management: Assisting Physicians in Formulating Rational Treatment Plans.

Acts directly on the respiratory muscles without increasing systemic oxygen consumption, and is not limited in patients with dyspnea.

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Li Qian

Founder and General Manager of Yaguo Technology Co., Ltd.

Senior Professor-Level Engineer, Master’s degree from the Chinese Academy of Sciences, and Engineering Doctorate in Innovation Leadership from Tsinghua University. Led the team in dedicated R&D of multiple products, establishing three product lines: critical care respiratory medicine, chronic respiratory disease management, and intelligent disease management systems. Developed numerous innovative medical device products and a series of algorithms that were the first of their kind both domestically and internationally, and led or represented the company in winning numerous honors at home and abroad.

Meanwhile, Ms. Li Qian serves as the Director of the Medical Device Professional Committee of the China-Africa General Chamber of Commerce and as an External MBA Mentor at Beijing Normal University. She has been honored with titles including Innovative and Entrepreneurial Talent by the Ministry of Science and Technology, National High-Level Talent, “New Gateway” Leading Talent, Scientific and Technological Leading Talent under the Suzhou Industrial Park “Jinji Lake Talent Program,” and Most Beautiful Scientific and Technological Worker in Daxing District.

Li Fengying

Sales Manager, Beijing Yaguo Technology Co., Ltd.

With years of sales experience, I have always been customer-centric, detail-oriented, and committed to continuously improving service quality, thereby earning high levels of customer trust and acclaim while achieving sustained growth in sales performance.

Song Kai

Sales Director, South China, Beijing Yaguo Technology Co., Ltd.

With over 10 years of experience in the medical device industry and more than a decade specializing in critical care respiratory solutions. Collaborated extensively with renowned Chinese experts in critical care and respiratory medicine. Served as National Sales Director for a company valued at over RMB 10 billion, leading the team to achieve annual sales exceeding RMB 500 million. Recipient of multiple Best Team and Top Sales awards.

Beijing Yaguo Technology Co., Ltd.Beijing Yaguo Technology Co., Ltd. is a national high-tech enterprise integrating R&D, manufacturing, and sales, with a focus on innovation in medical devices and solutions for airway management and respiratory therapy. Upholding the caring philosophy of “Gathering the Fruits of Thought, Restoring Elegance to Life,” Yaguo leverages advanced, safe, and efficient medical products and technical services. The company is committed to providing high-quality, comprehensive solutions to healthcare institutions, as well as patients with chronic diseases and critical illnesses, aiming to become a superior partner in intelligent airway management and respiratory therapy.

Yaguo currently has three product lines: respiratory critical care, chronic respiratory diseases, and intelligent disease management systems, encompassing nine medical device products and a suite of algorithms.Among these, the Intelligent Bionic Sputum Excretion System was recognized by Google X and the American Association for the Advancement of Science (AAAS) as one of the five Moonshot projects in the Asia-Pacific region. It was included in the “Key Export Products for Epidemic Prevention” published by the Beijing Municipal Bureau of Economy and Information Technology, and granted priority review status by the National Medical Products Administration (NMPA). This research achievement was assessed by the China High-Tech Industrialization Research Association as being at an internationally leading level. The Respiratory Neuromuscular Stimulator was approved by the NMPA as an innovative medical device. Available in multiple models—including hospital, community, and home-use versions—it covers the entire rehabilitation process for patients, thereby facilitating tiered diagnosis and treatment. The Airbag Manometer has been incorporated into the 13th Five-Year Plan textbooks, and related articles have been published in the Chinese Critical Care Medicine journal. Furthermore, in 2020, all three aforementioned products were selected for the “Catalogue of Urgently Needed Medical Equipment for COVID-19 Prevention and Control” certified by the China Association of Medical Equipment, as well as the “List of New Technologies, Products, and Services for Epidemic Combat” released by Zhongguancun.

As of April 2024, Yaguo has filed 75 patent applications, including 6 international invention patents and 37 Chinese invention patents; its series of products have reached more than 700 hospitals across 30 provinces in China and have been exported to over 30 countries overseas.

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