2024 Training Course on Construction of Biomanufacturing Pilot-Scale Platforms Announces Enrollment Surge Ahead of September 23–24 Session

The Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences; Bloomage Biotech; Dr. Fang; and VCBeat jointly launch the course “Ideas and Solutions for Building Pilot-Scale Platforms in Bio-Manufacturing in 2024.” Leveraging the mature expertise of institutions such as the Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, and Bloomage Biotech, the course helps bio-manufacturing enterprises efficiently overcome critical challenges.

Training Name: Training on Strategies and Plans for the Construction of Pilot-Scale Platforms in Biomanufacturing (2024)

Training Time: September 23–24, 2024 (tentative)

Training Location: Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences

Training Scale: 60-80 attendees (limited venue capacity; first come, first served)

Organizer: Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences; Professional Committee on Scientific and Technological Development and Consultation, Chinese Society for Microbiology; Bloomage Biotechnology Corporation Limited

Organizer: Dr. Fang, Beijing VCBeat Technology Co., Ltd. (VCBeat)

Total duration: 2 days, including 1.5 days (10 hours) of theoretical study and 0.5 days (2 hours) for pilot platform inspection.

TrainingTopicI:Intelligent Pilot-Scale Platform for Biomanufacturing

Title:Overall Strategy for the Construction and Operation of Pilot-Scale Production Platforms

1. Domestic and International Landscape and Development Trends of the Biomanufacturing Industry

2. The Importance of Pilot-Scale Platforms to National, Regional, and Enterprise Development

3. Positioning and Functions of the Biomanufacturing Pilot-Scale Platform: Process Optimization, Scale-Up Trials, Process Package Development, Application Development, Technology Transfer, and Incubation

4. Construction Content and Overall Framework of the Pilot-Scale Platform for Biomanufacturing, Including Pilot-Scale Fermentation, Downstream Processing, Industry R&D Laboratories, Analytical Testing Laboratories, and Utilities

5. Construction, Operational Models, and Sustainable Development of Pilot-Scale Platforms for Biomanufacturing, Including Funding, Talent, Projects, Management, Services, and Government-Enterprise Relations

Training Topic 2:Intelligent Pilot-Scale Platform for Biomanufacturing

Background, Challenges, and Solutions for the Construction of the High-Throughput Fermentation Module of the Pilot-Scale Platform (Part I)

1. Revolutionary Advances Driven by Synthetic Biology Biofoundries and Bottlenecks in the Industrialization of Their Outcomes

• The Paradigm Shift in Research Driven by Automated Equipment for High-Throughput Strain Construction

• The Significant Discrepancy Between High-Throughput Screening Standards for Microbial Strains and Industrial Environments

• Problems and Challenges Arising from Insufficient Throughput in Fermentation Optimization

2. High-throughput fermentation optimization is the key hardware system for resolving bottlenecks

• Research Progress and Development Trends at Home and Abroad

• Application Status of Mature, Commercialized Products

• Development and Existing Deficiencies of Corresponding Equipment Technologies in China

3. High-throughput fermentation optimization is the key software technology for resolving bottlenecks

• High-Throughput Experimental Design Methods

• High-Throughput Process Data Analysis Methods

• Applications of Data Science and Artificial Intelligence

Background, Challenges, and Solutions for the Construction of the High-Throughput Fermentation Module in the Pilot-Scale Platform (Part II)

4. Digitalization and Intelligence in the Construction of Pilot-Scale Platforms for Biomanufacturing

• Intelligent Sensing Infrastructure for Biomanufacturing Processes

• Digital Twins and Intelligent Decision-Making in Biomanufacturing Processes

• Potential Pathways to Achieving Intelligence in Biomanufacturing Processes

5. Talent Requirements for the Construction of Pilot-Scale Platforms in Biomanufacturing

• Demand for Interdisciplinary Talent in Biomanufacturing Processes

• Cultivation of Interdisciplinary Talents in Biomanufacturing Processes

• The Critical Role of Technical Managers in Biomanufacturing Processes

6. Reflections on the Operational Mechanism of Pilot-Scale Platforms in Biomanufacturing

• Construction of Credible Public Technical Service Platforms

• Mission and Responsibility of the Public Technical Service Platform

• Potential Operating Mechanisms for the Privatization of Pilot-Scale Platforms

Training Topic 3:Construction, Operation, and Application of Bloomage Biotech’s Pilot-Scale Platform

1. Significance and Positioning of Bloomage Biotech’s Pilot-Scale Platform Development

• Background & Significance of Pilot-Scale Platform Construction

• Positioning of the Pilot-Scale Platform Development

2. Characteristics and Capabilities of Bloomage Biotech’s Pilot-Scale Platform

• Characteristics of Pilot-Scale Platform Development

• Hardware Capabilities of the Pilot-Scale Platform

• Software Infrastructure Capabilities of the Pilot-Scale Platform

3. Service Model and Advantages of Bloomage Biotech’s Pilot-Scale Platform

• Service Model of the Pilot-Scale Platform

• Service Advantages of the Pilot-Scale Platform

• Service Cases of the Pilot-Scale Platform

4. Future Outlook

Training TopicIV：Intelligent Pilot-Scale Platform for Biomanufacturing

Development Strategy and Solutions for a Bio-Manufacturing Application Platform in the Food Sector

1. Background and Challenges in Building a Development Platform for Biomanufacturing Applications in the Food Sector

• Background of Biomanufacturing in the Food Sector

• The Significance of Platform Development: Driving the Transformation and Upgrading of the Food Industry

• Challenges Facing the Construction of Food Biomanufacturing Platforms

2. Research and Innovation in Platform Technologies for the Development of Biomanufacturing Applications in the Food Sector

• Process Innovation in Food Biomanufacturing Platforms

• Nutritional Evaluation of Food Bio-Manufacturing Platforms

• Toxicological Research on Food Biomanufacturing Platforms

• Applications of Food Biomanufacturing Platforms

3. Intelligent Construction of Bio-manufacturing Platforms in the Food Sector

• Hardware Specifications and Configuration for Food Biomanufacturing

• Talent Requirements for the Food Biomanufacturing Platform

• Management and Strategic Planning of the Food Bio-Manufacturing Platform

4. Summary and Outlook

• The Role of Platforms in Driving Technological Innovation in the Food Industry

• Outlook on the Long-Term Impact of Platforms on Sustainable Development in the Food Industry

Training TopicFive：Intelligent Pilot-Scale Platform for Biomanufacturing

Strategic Framework and Solutions for Building a Biomanufacturing Application Platform for Cosmetic-Grade and Pharmaceutical-Grade Products

1. Background and Challenges in Building a Biomanufacturing Application Development Platform for the Cosmetics and Pharmaceutical Sectors

• Background of Biomanufacturing in the Cosmetics and Pharmaceutical Industries

• Significance of Platform Development: Driving the Transformation and Upgrading of the Pharmaceutical Industry

• Challenges in Building Platforms for Cosmetics and Biopharmaceutical Manufacturing

2. Intelligent Construction Strategies for Biomanufacturing Platforms in the Cosmetics and Pharmaceutical Sectors

• Hardware Specifications and Configuration of the Pilot-Scale Platform

• Pilot-Scale Platform: Architectural Configuration and Talent Requirements

• Supporting Facilities Matching

3. Key Points in the Operation of Biological Manufacturing Platforms in the Cosmetics and Pharmaceutical Fields

• Quality System Level

• Registration Level

• Confidentiality Level

4. Summary and Outlook

Training TopicVI：Application Development Cases of Bio-manufacturing Related Products

1. Conditions Required for Pilot-Scale Amplification

• Process Stability and Product Stability

• Operating Conditions, Raw and Auxiliary Materials, and Three Wastes Issues

• Process Safety

2. Common Issues During Pilot-Scale Up

• Device Compatibility and Tolerance

• Performance Variations of Medical Devices

• Variations in Raw Materials and Excipients During Scale-Up

3. Bloomage Pilot-Scale Case Study

• Risks in the Pilot-Scale Amplification Process of BL-21 Series Strains

• Process Control During Escherichia coli Scale-Up

• Process Optimization During Pilot-Scale Scale-Up

*More training outlines are being continuously updated

● Professor Xia Jianye, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences

Xia Jianye, Researcher and Doctoral Supervisor, is a recipient of the Chinese Academy of Sciences (CAS) “Hundred Talents Program” and a Leading Talent in Tianjin. He serves as Vice Chairman of the Special Committee on Biochemical Process Modeling and Control under the Chinese Society for Microbiology, and currently holds the position of Director of the Pilot Platform for Intelligent Biomanufacturing at the Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences.He obtained his Ph.D. from East China University of Science and Technology in 2008, studying under Professor Zhang Siliang. He proposed a fermentation process optimization and scale-up method based on the integration of reactor flow fields and cellular physiology, which has been successfully applied in numerous biomanufacturing enterprises across China. His accolades include one Second Prize of the National Science and Technology Progress Award, one First Prize of the Shanghai Science and Technology Progress Award, and one Second Prize of the Science and Technology Progress Award from the China National Light Industry Council. He has published more than 30 research papers in journals such as *Cell*, *Nature Communications*, *Biotechnology and Bioengineering*, and *Trends in Biotechnology*, and holds five authorized patents.In July 2021, he joined the Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, as a full-time researcher, where he was responsible for establishing the laboratory platform of the Center for Intelligent Biomanufacturing. He built a 6,000-square-meter digitalized and intelligent biomanufacturing pilot platform, innovated the technical service mechanism for pilot platforms, and facilitated the industrial translation of three synthetic biology products from the laboratory to commercial production.

● Professor Sun Jibin, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences

August 2020–Present, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Director of the Center for Systems Biology

Research Areas: Systems biology of industrial microorganisms; multi-omics technologies; synthetic biology technologies; design and development of industrial microbial strains

● Professor Fu Shaoping, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences

Shao-Ping Fu, male, born in 1978, holds a Ph.D. and is a Senior Member of the Chinese Chemical Society. He serves as a Professor-Level Senior Engineer at the Center for Intelligent Biomanufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences. He received his Ph.D. in Analytical Chemistry from the Dalian Institute of Chemical Physics, Chinese Academy of Sciences, in March 2006. In the same year, he joined the School of Biological and Food Engineering at Dalian Polytechnic University. From 2008 to 2009, he conducted research on the separation and structural identification of complex components of plant natural products at the Universidad de Granada in Spain. In October 2012, he joined the Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, where his main research focus has been on the separation and purification processes for bio-fermentation products. He has presided over key projects under the Tianjin Municipal Science and Technology Support Program and the National Key R&D Program. He was responsible for completing the development of separation and purification processes for more than thirty industrialization projects involving lycopene, inositol, protocatechuic acid, and other compounds, generating significant economic value. His honors include the Second Prize for Scientific and Technological Progress of Dalian City (2010), the Second Prize for Scientific and Technological Progress of Liaoning Province (2011), selection as one of the “Top 1,000 High-Level Talents Introduced within Three Years” in Tianjin Municipality (2012), selection as a Tier II candidate in the “131” Talent Training Project of Binhai New Area, Tianjin (2013), recognition as a “Key Technical Talent” of the Chinese Academy of Sciences (2019), and appointment to the “Distinguished Research Backbone Position” of the Chinese Academy of Sciences (2022).

● Professor Xia Xiaole, Academic Dean of the College of Food Science and Engineering at Tianjin University of Science and Technology, and Professor at the School of Biotechnology, Jiangnan University

Primary Research Areas:

1. Future Fermented Foods

Based on evolutionary analysis, synthetic biology and computational biology approaches are employed to identify, analyze interactions, and reconstruct the core microbiota of traditional fermented foods, aiming to address issues such as food safety and flavor enhancement in industrial practices.

2. Synthetic Biological Manufacturing of Bioactive Macromolecules

Health-relatedActivityMacromolecules, such as lipopeptides, hydrolases, and Monacolin K, leverage computational biology and synthetic biology to address challenges in their synthesis, expression, and engineering, with applications in the life and health sectors.

● Wang Enxu, Assistant General Manager of the Pilot Scale Achievement Transformation Center at Bloomage Biotech

Wang Enxu, Ph.D. candidate, Senior Engineer (Associate Professor level), Adjunct Master’s Supervisor at Tianjin University of Science and Technology, currently serves as Assistant General Manager of the Pilot Scale-up and Technology Transfer Center at Bloomage Biotechnology (Tianjin) Co., Ltd. He possesses comprehensive expertise in end-to-end technologies within synthetic biology, from upstream to downstream processes. With a holistic understanding of process development, scale-up, optimization, and commercial manufacturing of microbial fermentation products, he brings extensive experience in process development and industrial translation, dedicated to crafting tailored bioprocessing solutions for clients. He has established an elite team of 150 professionals and forged deep collaborations with numerous prestigious universities and research institutions, successfully completing pilot scale-up and industrial translation for over 20 bioactive substances. Furthermore, he has participated in or led multiple large-scale projects, including the construction of the Pilot Scale-up and Technology Transfer Center, which involves a total investment exceeding RMB 1 billion and covers an area of 30,000 square meters. This project integrates advanced flexible production line designs, capable of simultaneously supporting pilot experiments and small-scale commercial production for six major categories of substances: functional sugars, proteins, peptides, amino acids, nucleotides, and natural active compounds, thereby laying a solid foundation for the company’s future industrialization strategy.

● Xue Guoxi, Process Director of the Pilot Scale-up and Technology Transfer Center at Bloomage Biotech

Xue Guoxi, Master’s degree holder, with 16 years of experience in drug R&D at large pharmaceutical companies. Currently serves as the Process Director of the Pilot Scale Achievement Transformation Center at Bloomage Biotech (Tianjin) Co., Ltd. He has led and completed one National Science and Technology Support Program project (RMB 100 million), one major science and technology special project of Shandong Province (RMB 15 million), and one scientific and technological plan project funded by the Huayanghe City Finance Bureau (RMB 1.5 million). He holds four authorized patents. He spearheaded the R&D and scale-up of 16 raw materials for pharmaceutical, food, and cosmetic grades, among which three products generate approximately RMB 500 million in annual profit for the company. He completed drug registration filings for six microbial fermentation projects and underwent two FDA inspections and six GMP compliance inspections. He was responsible for the design and construction of fermentation and purification workshops with a fermentation capacity of 500 tons, and successively established and operated six R&D and pilot-scale platforms.

● Rong Jinlei, Process Director of the Pilot Scale-up and Technology Transfer Center at Bloomage Biotech

Rong Jinlei, Master of Science, currently serves as the Process Director at the Pilot Scale Achievement Transformation Center of Bloomage Biotechnology (Tianjin) Co., Ltd. With nearly two decades of specialized experience in the development and optimization of microbial fermentation, extraction, and purification processes, he has accumulated extensive expertise in project development and scale-up for active pharmaceutical ingredients (APIs) of small-molecule bioactives, antibiotics, peptides, proteins, and macromolecular polysaccharides. He has achieved outstanding results in industrial fermentation medium optimization, fermentation process improvement, and separation and purification optimization. The multiple products he led in development have achieved industry-leading standards in both cost efficiency and quality. As a key member, he participated in the project on Key Technologies and Industrialization of Glutathione (GSH) API and Formulations, which was awarded the First Prize for Provincial Scientific and Technological Progress.

*More instructor profiles are being continuously updated

The Intelligent Biomanufacturing Center is one of the six platform laboratories established under the National Center for Technology Innovation in Synthetic Biology. It serves as a biomanufacturing pilot-scale platform that provides technical services and conducts key R&D activities essential for the industrialization of synthetic biology innovations, including strain performance validation, pilot process development and verification, trial production of samples ranging from kilograms to hundreds of kilograms, and scale-up of biomanufacturing processes.Officially approved for establishment in September 2021, the Center has invested RMB 130 million in equipment and infrastructure, constructing 6,000 square meters of new laboratory space. Its equipment portfolio covers the entire chain of bioprocess development, optimization, and scale-up, including high-throughput strain performance validation, high-throughput media optimization, high-throughput fermentation process optimization, and digitalized, intelligent pilot production lines.Focusing on intelligent manufacturing technologies for industrial biological processes, the Center develops key technologies such as strain validation, media optimization, process scale-up, and intelligent biomanufacturing process packages. It drives the technological upgrade of traditional fermentation industries toward automation and intelligence, comprehensively supporting the efficient industrial translation of synthetic biology achievements. By significantly reducing the time and cost required to transfer high-performance strains from laboratory development to industrial production, the Center provides intelligent manufacturing process packages ready for industrial-scale production.Since its inception, the Center has actively explored new technical service models. It has introduced a novel pilot-scale service mechanism focused on ensuring core strain safety and innovatively proposed three customized and personalized service models: “Shared Kitchen,” “Shared Chef,” and “Commissioned Development.” To date, it has served more than 20 domestic biomanufacturing enterprises, successfully facilitating the industrial production of three biomanufacturing products transitioning from the laboratory stage, achieving remarkable results.

Bloomage Biotechnology (688363.SH), established in 2000, is a globally renowned biotechnology and biomaterials company. Driven by synthetic biology, the company is committed to continuously improving quality of life and extending lifespan, delivering healthy, beautiful, and joyful life experiences for humanity. Upholding its corporate mission of “Keeping Every Life Vibrant,” the company focuses primarily on the development and industrial application of bioactive substances beneficial to human health, including functional sugars, proteins, peptides, amino acids, nucleotides, and natural active compounds. As the world’s largest enterprise engaged in the research and development, production, and sales of hyaluronic acid, Bloomage Biotechnology ranks first globally in the industrialization of hyaluronic acid.

Ph.D. in Economics from Zhejiang University; Original Author of the WeChat Official Account “Dr. Fang”

Managing Director at Titanium Capital, overseeing government and corporate ecosystem partnerships, with a focus on synthetic biology, healthcare, and industrial internet.

During my tenure at the High-Tech Division of the Xiamen Municipal Development and Reform Commission, I was responsible for “mass entrepreneurship and innovation” initiatives, including the planning of startup parks, the drafting and promotion of entrepreneurial policies, and the implementation of policies for attracting high-end talent. Previously, I served in the Strategy Department of the Xiamen Development Research Center, where I led research projects on the Belt and Road Initiative and regional economic trends. I also contributed to the editing of internal reference reports at the Zhejiang Provincial Policy Research Institute, with more than ten reports receiving written instructions from senior leaders, including the then Secretary of the Zhejiang Provincial Committee of the Communist Party of China.

He also serves as a Distinguished Research Fellow at the Industrial Research Center of Fudan University’s Zhangjiang Institute, a member of the Expert Advisory Committee of the Xiamen Guoxin Credit Big Data Innovation Research Institute, and a consultant for multiple startup enterprises.

Tech projects involving investment, financing, or consulting services have secured over RMB 10 billion in funding, including Anchnet, HEC Pharm, Crown Bioscience, Lifechem Pharmaceutical, Yunyin Technology, and U-Lase.

Areas of Expertise: Regional development planning, policy consulting and project application, business plan writing, startup pitch coaching, corporate business and financial structuring, and investment and financing matchmaking.

VCBeatFounded in 2014, it is a company that leverages data as its foundation, research as its core, and brand media as its connector to facilitate the precise aggregation of industrial resources and help industry changemakers achieve rapid growth.Innovative Industrial Service Agency. Egg Yolk Tech focuses on the life and health sector, providing services such as brand communication, research consulting, data monitoring, and resource/project matchmaking to enterprises, scientists, government industrial parks, investment institutions, and other entities within the industry chain. Since its establishment, Egg Yolk Tech has received investments from multiple renowned firms, including Legend Capital, BV Baidu Ventures, Honghui Capital, Changling Capital, Yifang Group, and Weilai Capital, achieving a valuation of several hundred million RMB. Under the Egg Yolk Tech umbrellaVCBeat, innovation and investment in China's pharmaceutical, healthcare, and broader health industryOne of the Well-Known Media Outlets。