Nuoyun Bio Files IPO Prospectus: Pioneering Anti-Aging Solutions with 99.9% Pure NMN via Synthetic Biology
In 1946, the first World Health Assembly designated October 13 as “World Health Day,” advocating for commemorative activities worldwide to raise awareness of the importance of health. This year’s theme is “Maintain Health, Start Now.” Achieving a longer, healthier, and more fulfilling life has become a critical issue for global public health, aligning closely with the traditional Chinese concept of “prolonging life and enhancing longevity.”
In the field of biology, numerous authoritative studies have revealed various genes and mechanisms that influence longevity. The following are some key research findings:
Environmental factors such as diet, stress, temperature, and social interaction also have a significant impact on longevity;[1]
Overexpression of specific genes, such as SIRT6, can significantly extend lifespan, indicating that genes play a crucial role in regulating the aging process;[2]
Signaling pathways such as insulin-like growth factor-1 (IGF-1) and AMP-activated protein kinase (AMPK) play a key role in regulating mitochondrial function and lifespan;[3]
Thus, the relationship between longevity and mitochondria is a complex and important area of research. Optimization of mitochondrial function is considered one of the key approaches to extending lifespan.
In 2023, a research finding on the “Relationship Between Mitochondria and Aging” publicly released by the Buck Institute for Research on Aging in the United States sparked significant repercussions in the scientific community.[4]
In this clinical study, researchers were surprised to find that the mitochondrial size in aging experimental C. elegans was significantly reduced. However, after activating key genetic signals for mitochondrial fission, the mitochondria in the nematodes showed improvement, resulting in a 40% extension in lifespan. Moreover, the survival rate of Experimental Group 3 was 300% that of the normal control group.
Subsequently, the Russian Academy of Sciences and the UCL Cancer Institute at University College London jointly released an in-depth statistical study that revealed the link between mitochondria and human longevity.[5]
This study, initiated in 2003, enrolled 9,360 participants who were stratified into 10 groups based on their mitochondrial levels, and a 15-year follow-up study was conducted.
The study results showed that, after comparing participants in the lowest and highest mitochondrial count groups, the mortality rate in the former was 2.35 times that of the latter. Specifically, individuals with lower mitochondrial counts faced a 92% increased risk of death from cardiovascular diseases and a 266% increased risk of death from cancer.
Mitochondria, as the "powerhouses" of human cells, play a pivotal role in sustaining vital activities and promoting longevity. To enhance mitochondrial function, researchers have explored various approaches, among which supplementation with NMN (β-nicotinamide mononucleotide) has garnered significant attention.
NMN is the direct precursor of NAD+ (nicotinamide adenine dinucleotide), a crucial coenzyme indispensable for mitochondrial metabolism. Appropriate supplementation with NMN can effectively elevate intracellular NAD+ levels, thereby activating a series of NAD+-dependent enzymes, particularly longevity-associated proteins such as Sirt3. These enzymes help restore the normal function of mitochondrial proteins by removing acetylation modifications, thus enhancing mitochondrial efficiency, optimizing energy production, and potentially mitigating age-related decline.
Taking Japan, the country with the highest life expectancy globally, as an example, in March 2020, Japan revised the “List of Ingredients (Raw Materials) Not Classified as Pharmaceuticals Provided That No Pharmaceutical Functions or Efficacies Are Claimed.”[6], thereby officially approving NMN in Japan for use as a food ingredient and expanding its application scope within the Japanese food sector. On August 16, 2024, Japan’s Consumer Affairs Agency (CAA) granted its first approval for NMN with triple functional properties as a “functional” food ingredient, formally incorporating it into the category of foods with function claims.
On July 27, 2024, the Japanese financial publication Weekly Toyo Keizai published an article titled “The NMN Anti-Aging Craze,” reporting that the market size for NMN in Japan had reached tens of billions of yen and continued to grow.
In the early stages of large-scale NMN production, chemical synthesis was the predominant method, particularly before 2010. This approach utilized raw materials such as adenosine monophosphate (AMP), tetraacetylribose, and nicotinamide (NAM) to synthesize NMN through complex chemical reactions. However, due to challenges associated with chemical synthesis, including low yields and environmental pollution, researchers have shifted their focus toward biosynthetic methods in an effort to identify new avenues for enhancing NMN production.
Nanjing InnovaSyn Biotech Inc. (hereinafter referred to as “InnovaSyn Biotech”) is one of the companies that have achieved significant results in this field.
Since its establishment in March 2013, InnovaSyn Biotech Inc. has centered on synthetic biology technology, focusing on the research, development, and production of synthetic biological solutions. Its product portfolio extensively covers nutritional health ingredients, medical aesthetics raw materials, NAD-series coenzymes, and pharmaceutical intermediates. Leveraging robust R&D capabilities, InnovaSyn Biotech was recognized as a High-Tech Enterprise in 2016 and has accumulated more than 80 invention patents to date.
In August 2024, InnovaSyn Biotech Inc. won the first prize in the finals of the Synthetic Biology Special Competition at the 12th “Entrepreneurship Jiangsu” Science and Technology Entrepreneurship Competition.
InnovaSyn Biotech has developed a series of practical genome editing tools and screening technologies through independent R&D, including CMR microbial genome multiplex knockout technology, Seamless Fusion-based library construction technology, and HES high-throughput enzyme screening technology. Leveraging its proprietary genetic manipulation technologies and extensive industrialization experience, the company has achieved rapid product commercialization and swift process iteration. To date, the company has completed three iterations of its NMN and NAD production processes, becoming the first manufacturer globally to consistently maintain NMN purity at 99.9%.
InnovaSyn Biotech Product Overview
Wang Yong, Founder and General Manager of InnovaSyn Biotech Inc., once stated, “As a vitamin derivative and an endogenous substance in the human body, NMN participates in numerous energy metabolism processes, holding immense market potential.” However, selecting the right product category is only part of the equation; sustained revenue and market share depend on key factors such as “deepening expertise in the nucleotide series, leveraging first-mover technological advantages, pursuing continuous technological innovation and iteration, and upholding a long-term commitment to quality.”
In terms of patents, InnovaSyn Biotech Inc. has been deeply engaged in the field of synthetic biology for over a decade, accumulating substantial R&D capabilities. To address the limitations of existing processes for preparing β-nicotinamide mononucleotide (NMN), the company has invented an industrial-scale preparation process characterized by operational simplicity, ease of scale-up, and superior product quality. During the phosphorylation stage, technological improvements have eliminated the need for highly irritating phosphorus oxychloride, thereby ensuring safer and more environmentally friendly production operations that are more conducive to industrial scale-up and manufacturing.
In terms of production, the company currently operates three manufacturing bases in Changzhou (Jiangsu), Songyuan (Jilin), and Zoucheng (Shandong). The Changzhou base is equipped with pilot-scale and synthesis workshops, with an annual amino acid production capacity of nearly 1,000 metric tons. The Jilin base has established a cGMP-compliant production management system, obtained ISO 9001, FSSC 22000, and Halal certifications, and rigorously implements QA/QC quality control systems and standard operating procedures (SOPs) for each position to meet the demands of domestic and international customers. The Zoucheng (Shandong) base is primarily responsible for the research, development, and manufacturing of cosmetic raw materials.
In terms of manufacturing processes, InnovaSyn Biotech Inc. employs cutting-edge enzymatic production technology to enhance product purity, consistently maintaining a purity level above 99.9%. Through meticulous process control and a rigorous quality management system, the company continuously provides customers with safe, efficient, and pure NMN products, earning widespread market recognition and trust.
Furthermore, InnovaSyn Biotech Inc. has joined forces with the National Engineering Laboratory for Cereal Fermentation Technology at Jiangnan University. Having established a robust R&D framework encompassing microbial metabolic pathways, targeted engineered strain construction, and efficient microbial bioconversion, the company has taken solid strides toward industrial-scale manufacturing.
In terms of market presence, InnovaSyn Biotech Inc. is simultaneously expanding its footprint in both domestic and international markets. Taking gamma-aminobutyric acid (GABA) as an example, since commencing overseas trade in 2021, the company’s export market share from China to India has continued to grow, rising from 40% in 2022 to 50% by the end of 2023. In addition to GABA, products such as NMN, GSH, and NAD are also seeing sustained progress in overseas sales across North America, Europe and Asia, as well as Japan and South Korea.
As InnovaSyn Biotech Inc. continues to grow and expand, it has established offices in Europe and the United States, East Asia, and Japan, further expanding its overseas markets.
Literature Source:
[1] https://accessapps.amdi.usm.my/reqba_uploads/ebook/Handbook of the Biology of Aging 8th edition.pdf
[2] https://zhuanlan.zhihu.com/p/377623539
[3] http://swxxx.alljournals.cn/html/2019/4/20190401.html
[4] https://www.nature.com/
[5] https://www.researchgate.net/
[6] https://news.foodmate.net/