MATLAB-Powered Mechanistic Modeling: Gaining an Edge in Innovative Drug Development
The overseas clinical trial and approval success rate for Chinese innovative drugs stands at merely 1.7% (compared to the global average of 7.9%), with the Phase II clinical trial success rate as low as 17%. These figures underscore critical flaws in clinical protocol design: lack of rationale for dosing regimens and dose selection, ambiguous inclusion criteria, and ill-defined endpoints. Given the limitations of the traditional “cash-burning trial-and-error” model, there is an urgent need for “scientific prediction” in innovative drug development.
The SimBiology platform based on MATLAB provides an efficient solution to this need. This platform enables the rapid construction of transparent, disease-specific models for various therapeutic modalities—including PROTACs and mRNA therapies—by integrating pharmacokinetic (PK) or detailed physiologically based pharmacokinetic (PBPK) models. Furthermore, the platform’s integrated environment enhances the reproducibility and transparency of results, offering robust scientific support for drug development.
This episode of "Artery Open Class" invitesMathWorks Team, bringing us"MATLAB-Driven Biomechanistic Modeling: Gaining a Competitive Edge in New Drug Development"Topic Sharing. In this session, you will learn how to optimize and accelerate the drug development process through modeling and simulation, significantly boosting the success rate of innovative drugs!
Scan the QR code on the poster below to reserve your spot for the live stream.
Course Duration:September 10, 2025 (Wednesday) 14:00-15:30
Course Topic:《MATLAB-Driven Biomechanistic Modeling: Gaining a Competitive Edge in New Drug Development》
Course Highlights:
· How to Build and Customize Mechanistic Models for Multiple Therapeutic Approaches
· How to Calibrate Models Using Experimental Data
· How to Evaluate the Impact of Parameters on Key Biomarkers
· How to Generate Virtual Populations
· How to Explore Hypothetical Scenarios to Optimize Dosing Strategies
· Case Sharing:
Pfizer Pharmaceuticals:Adopting Model-Informed Drug Development to Reduce Phase II Attrition Rates
MIT ：Development of Synthetic Circuits to Control Protein Expression Variations Arising from Changes in Gene Dosage
Yueyi Xu, Engineer, MathWorks China Academic Team. Primarily responsible for university collaborations and supporting faculty in teaching and research. Holds a B.S. in Chemical Engineering from Dalian University of Technology and a Ph.D. in Chemical Engineering from Texas Tech University. Previously engaged in research related to molecular dynamics simulations.
Dan Bo, Healthcare Industry Marketing Manager for China at MathWorks. He has long been responsible for in-depth technical support in China for image/medical image processing, artificial intelligence, and high-performance embedded hardware implementation. Prior to joining MathWorks, he worked in R&D for many years, accumulating extensive experience in medical image recognition, computer vision, time-series signal processing, and high-performance implementation on FPGAs and GPUs.
MathWorks is the world’s leading developer of mathematical computing software. Its flagship product, MATLAB, is a programming environment for algorithm development, data analysis, visualization, and numerical computation, often referred to as “the language of technical computing.” Simulink is a graphical environment used for simulation and model-based design of multi-domain dynamic systems and embedded systems. Engineers and scientists worldwide rely on MathWorks’ product families to accelerate invention, innovation, and development in industries such as automotive, aerospace, electronics, financial services, biomedicine, and more. In addition, MATLAB and Simulink serve as fundamental teaching and research tools, adopted by numerous universities and educational institutions around the globe. MathWorks currently employs over 6,000 people and operates 34 offices worldwide.
“VCBeat Open Course” is one of the brand columns under VCBeat. Focusing on the development pain points in the medical field and discussions of systematic solutions, it continuously invites senior industry practitioners and experts to jointly develop a series of thematic courses by building an online live-streaming platform for knowledge sharing and communication. It aims to provide in-depth and valuable content for healthcare enterprises. VCBeat Open Course: Making the choice of knowledge simpler.