Click the image to view event details.

Monthly Report on Overseas Developments in Synthetic Biology

This monthly report’s statistical analysis reveals that, in the international market, a total ofFive biomanufacturing companies completed financing, with a total funding amount of RMB729 million yuan.

From other developments,Corporate Expansion Coexists with Shutdowns, it is worth pondering:

What Are the Key Factors for Successfully Scaling Up Biomanufacturing? Success in Small-Scale Validation Does Not Equate to Feasibility in Large-Scale Operations, Let Alone Profitable Commercialization.Behind successful scaling lies a deeply optimized process flow, which ultimately resolves the key bottlenecks in expansion.

While market gaps may attract attention temporarily and technological advantages can provide a lead, ultimate success hinges on details, processes, and efficiency.

EVERY CoComplete5500$10 Million Financing: Precision Fermentation Proteins Move from Concept to Scale.

EVERY CoCompleted5500USD (equivalent to approximately RMB3.9100 million yuan)DFirst tranche of the financing round, with cumulative funding reaching2.94hundred million U.S. dollars. The products are about to be listed in Walmart stores across the United States and have entered the supply chains of major global food enterprises. The main product currently is ovalbumin (OvoPro), can replace liquid eggs, provided in powder form, with a shelf life of up to 18month.

Demand in this sector is driven primarily by economic and supply chain stability concerns, rather than purely ethical or sustainability considerations. Conventional egg products are constrained by issues such as price volatility, Salmonella risk, and avian influenza, prompting food companies to seek stable alternatives.EVERY CoCurrently manufactured in Europe, with plans to add a second manufacturing partner in the United States to enhance supply chain resilience. With the Abu Dhabi Investment Authority (ADIO) in collaboration with, to explore the construction of in the United Arab Emirates400Wansheng Alternative Protein Plant Meets the Region’s High Dependence on Egg Products, with Import Ratios in the Gulf Region Reaching as High as70%。

Gas-Fermented ProteinSolar FoodsofSoleinFirst Application in the United States

U.S. Health and Performance Nutrition Startup Fermentawill be in 2026 Limited Edition Launched in Q1GutsyBranded Protein Bars: First Use in the United States by a Finnish CompanySolar FoodsGas Fermentation ProteinSolein。SoleinProduced by fermenting carbon dioxide, hydrogen, and oxygen, it does not rely on farmland, irrigation, or chemical fertilizers and pesticides. The final product is an odorless powder containing78%Protein,6%Fat,10%Dietary fiber, with nutritional properties similar to soybeans or algae, and rich in iron and vitaminsB12。

Solar FoodsTo the United States this yearFDAConfirmGRAS, has already been in a series of products in SingaporeSolein Commercialization, including mooncakes, ice cream sandwiches, chocolate snack bars, and soy-free lattes. In addition, a type of usingSoleinegg-free and dairy-free mayonnaise.

Australian Seaweed Materials CompanyUluuCompleted160010,000 (approx.7400RMB 10,000) in Australian dollar financing, accelerating the commercialization of alternative plastics.

UluuIndicates that the funds will be used to convert existing100kg/Annual pilot plant expanded to10Ton/demonstration plant with an annual production capacity, established in Western Australia. Future plans include the construction of a commercial-scale facility capable of producing thousands of tons per year.

Currently,UluuCollaborations have been established with multiple international brands, includingQuiksilver、Papinelle、Audi etc., with application scenarios spanning the cosmetics, fashion, and automotive industries.

UluuAlgae-based materials are considered to have properties comparable to traditional plastics, featuring high strength, light weight, water resistance, and non-toxicity, and can be processed using existing plastic manufacturing equipment. Meanwhile, these materials are reusable, recyclable, home-compostable, and marine-degradable, offering significant advantages in environmental friendliness.

UluuThe financing and production expansion plans also highlight the market potential of algae-based materials. In addition toUluuIn addition, there are already in the marketNotpla、B’ZEOS、KelpiAs companies lay out relevant technologies, it indicates that this field is rapidly heating up.

Waste-Derived FermentationGreen Spot TechnologiesCompleted50010,000 euros (approximately4100(ten thousand yuan) in financing, launches cocoa substitute

The company converts food industry by-products (such as spent brewery grains, tomato skins, and grape pomace) into high-fiber, nutrient-rich powdered ingredients through dry fermentation, a process that conserves water compared to wet fermentation.60%, and has avoided approximately 235Emissions from food waste (in tons).Green SpotPlan to increase the annual production capacity from100tons increased to1,000tons, and launched a new brandMilatea, specializing in cocoa alternatives.

Green SpotIt is one of several alternative chocolate startups that attracted investment this year, including manufacturers of cocoa-free chocolate.PreferandWin-Win, and cell-based Keke CompanyFood BrewerandPluri. The cocoa industry faces an existential threat from the climate crisis, with scientists warning that by2050By year, one-third of the cocoa trees may die.

Singaporean StartupsUmami BioworksCell-Cultured Seafood Supplements to Address Nutritional Deficiencies in Non-Seafood Consumers.

Umami BioworksRenowned for cultivating seafood, it has now expanded into the supplements and cosmetics sectors. Fish-free alternatives account for only a fraction of the seafood market.1%. Vegan/Vegetarian Seafood Alternatives Are Often Lacking in Protein and VitaminsB12Vitamins D, iron, zinc, iodine, and highly absorbableomega-3. ViaAIPlatformAlkemystCultivating marine cells to produce bioactive substances identical to those found in fish: Pureomega-3, collagen peptides, selenium,B12etc.

Umami Bioworks LaunchedMarine RadianceSeries, includingPDRN. In addition, with JapanIntegriCultureCo-develop skincare products; collaborate with James Cook University on research into hypoallergenic farmed seafood. The company plans2026In the second quarter of the year, the first batch of supplements and cultivated seafood will be launched, targeting markets in nutrition, functional health, and beauty.

Finnish Functional Mushroom Biotechnology CompanyKÄÄPÄ Biotech Announced Completion900€10,000 (approx.7400RMB 10,000) Strategic Investment

This strategic investment will accelerate KÄÄPÄ BiotechHigh-quality, traceable, and clinically validated NordRelease® Bringing functional mushroom ingredients to the forefront of global health and wellness. The company will increase production capacity, expand vertical integration, scale up operations, and consolidate its NordRelease® Ingredients: Their Position in the Global Nutraceutical Market, Driven by Surging Demand in the Health, Nutrition, and Supplements Sectors.

CortevaLaunch of Its First Biopesticide: It Is Crucial to Combine Biological Agents with Chemically Synthesized Formulations.

Crop Protection Company Spun Off from DuPont and Dow Corteva Announces the Launch of Its First BiopesticideGoltrevo, and simultaneously release based onspinosadsynthetic insecticides VarpelgoThis move reflects the company’s future strategy: integrating biologics with traditional chemical agents to enhance crop protection efficacy. This represents not only product-level innovation but also a transformation in business model and R&D pipeline—from single chemical products to biologics, and ultimately to biosynthesis-driven hybrid solutions.

NextProteinAcquired2070USD 10,000 (approximately1.5billion yuan)BRound of financing, building mainstream insect-based ingredients with cost competitiveness and industrial scalability

An Agri-Tech Company Headquartered in Paris and TunisNextProteinPlans are underway to construct a second production base in Tunisia, with an estimated annual output of12,000 tons of insect raw materials, including2,500tons of protein powder.NextProteinBy utilizing black soldier fly larvae (BSF) Converting low-value agricultural and food by-products into protein powder (nextMeal), oils and fats (nextOil) and fertilizers (nextGrow), primarily supplying the aquaculture, livestock farming, and pet food industries, thereby replacing traditional, resource-intensive feed ingredients such as fish meal.

CompanyThe model emphasizes capital and operational efficiency, deeply optimizes process workflows, and aims to address key bottlenecks in industry expansion.，and provide low-cost raw materials with global supply chain competitiveness. The team has tested over100formulations, continuously optimizing feed conversion ratios to enhance industrial scalability. Just last month, a South African insect protein companyInsecoBankruptcy due to production failures caused by the power crisis highlights the high sensitivity of insect farming to energy stability. Investors believeNextProteinThese technologies and scalable production capabilities are poised to transform insect protein from a niche sustainable product into a mainstream industrial ingredient globally.

Pow.BioContinuous Biomanufacturing Platform Successfully Expanded to3000Increase, Cost Reduction50%

This move is regarded as a significant step toward promoting the large-scale application of continuous fermentation in global biomanufacturing.Pow.BiowithBühlerGroup andATV TechnologiesCompleted in collaboration. The trial was conducted in France.CompiègneofATVfacilities. Compared with traditional batch processes, continuous fermentation achieves3Double the output of high-quality dairy protein. Projected costs (COGS) can reduce by more than50%, highlighting the economic viability of continuous processes.Pow.BioThe use of machine learning algorithms and model predictive control systems has significantly improved process outcomes.Pow.BioEstablished in California, USA this year2.5a 10,000-square-foot new facility, serving as a demonstration of its platform’s scalable deployment.

EnzymitAchieving the World's First Pilot-Scale Cell-Free Hyaluronic Acid Production

Israeli Cell-Free Bio-Manufacturing Synthetic Biology CompanyEnzymitAgricultural cooperatives renowned for the sustainable production of plant-based ingredients CosunCollaboration has reached an important milestone. They jointly achieved this using a pure enzyme, cell-free method.200Hyaluronic Acid (HA) pilot-scale production. The global market value of hyaluronic acid products2025Year94.3billion USD, expected to2035will expand to159.4hundred million U.S. dollars, highlighting the growing demand for high-purity, high-performance biomaterials. This production run yielded several kilograms of high-purity hyaluronic acid. The company’s next target is human milk oligosaccharides (HMO）。

Enzymit The innovative cell-free process allows manufacturers to determine the size of hyaluronic acid during production. This method can achieve approximately10 kDato4 MDaof the specified size to create a narrow size distribution ofHA, all of which can be achieved through standard production settings without modifying the enzyme or organism.Enzymitcell-free biomanufacturing platform that employs AI-designed enzymes to synthesize complex biological products without relying on living cells, thereby enabling a faster, cleaner, and more efficient production process.

Samsung BiologicsAnnounced the completion of itsBioepisSpin-offs, Sharpened FocusCDMOStrategic Positioning.

Samsung Biologics has separated its investment and subsidiary management business units to establish SamsungEpis Holdings. Samsung Biologics stated that it will focus onCDMOBusiness operations are centered on three major objectives: expanding production capacity, diversifying the service portfolio, and strengthening global presence. The company plans to2032Second Bio-Park completed in [Year], with total production capacity increased to 132.4WuXi Biologics continues to maintain its position as the world's largest biologics manufacturer.

Currently, Samsung Biologics operates five manufacturing facilities worldwide, with a total production capacity of78.410,000 liters, and throughExellenS™ Standardized frameworks enable equivalence and digitalization of manufacturing networks. Its customer base has expanded from the global top20Major Pharmaceutical Companies Expand to the Forefront40large, and accelerate entry into the Japanese and Asia-Pacific markets. The future product portfolio will cover antibody-drug conjugates (ADC), and other next-generation therapies such as organoids.

Danish Insect Agriculture CompanyENORMDeclared bankruptcy.

ENORMThe company persisted for six months through a court-supervised restructuring process but ultimately filed for bankruptcy in recent days. The company had previously2022Annual Fundraising5000ten thousand euros, and2023Established a plant in the Jutland Peninsula in , with an annual production target of11,000 tons of black soldier fly larval protein powder, becoming one of the largest insect farming facilities in Europe. Despite strong early market interest, by2024Demand weakened significantly at year-end, and sales fell short of expectations, leading to a break in the capital chain.

Several Insect Farming Companies Face Difficulties: South AfricaInsecoCeased operations, France ŸnsectSeeking Court Protection, Canada Aspire Food GroupAssets were sold. However, new players in the field are still securing financing, such asnextProtein（2100ten thousand U.S. dollars) andVolare（3000USD 10,000).

Fungal Protein CompaniesMeati FoodsPlunged into Crisis Again, Wages Delayed

Famous Mycelium-Based Meat Alternative CompanyMeati FoodsOnce again plunged into financial and operational crisis. Since9Since the end of last month, the company has repeatedly delayed or failed to pay salaries. Currently,MeatiLocated at the Thornton, Colorado facility8fermenter, only operating within it2Production has nearly ground to a halt. The company attempted to promote its direct sales business and planned to launch new grinding products containing some soybean, but the outlook remains uncertain. New owners Meati Holdings stated that the recent freezing of its bank accounts reflected confusion over liabilities, but the issue has now been resolved and there are no outstanding debt problems.Meati HoldingsExpanding the product line, preparing to2026Yearly brand rebranding.

This Year2Month,MeatiFinancial covenants linking revenue to gross profit have led to the primary lendersTrinity CapitalWithdrew two-thirds of the company's cash.CEO Yasir AbdulUpon taking over, one needs to assume approximately1350Tens of thousands of dollars in debt and tax liens, with cash flow remaining under persistent strain.Meati Has received over3.75$100 million in financing, enteringKroger、Whole FoodsWait7000Multiple stores. Morale was high early this year due to new product launches and distribution expansion, but it subsequently took a sharp downturn, leaving the future trajectory fraught with uncertainty.

Fork & GoodAcquisition of Cultivated MeatOrbillion Bio, integrationB2BPlatform

These two U.S. companies are undergoing deep integration to address the awkward situation of a sharp decline in investment and financing in this sector. The new company will adopt“Profit Margin Priority”Strategy: First validate medium-scale economies, then expand to ensure cost competitiveness.

Fork & GoodProducing cultured pork using a patented integrated cell manufacturing platform, with its pilot facility capable of operating in less than800 approximately in square feet of space7tons of products. With the expansion of scale,Fork & GoodThe goal is to set the cost at a commercial level per pound of biomass.5U.S. dollars, ultimately making it per pound2The price of commodity pork in US dollars remained flat. AndOrbillionAn algorithm has been developed that can, at low cost and in record time,2DCulture conversion to3DCulture. It has been completed200Enhance the production of Wagyu beef and collaborate with premium meat manufacturers in the Netherlands Luiten Food Collaboration, opened its 1,200 distribution points. The merged company is preparing to enter the U.S. FDA Submit Application, Fastest 2026 Cultured pork to be launched in Q2.

Chocolate Giant Barry Callebaut and the Cocoa-Free Chocolate CompanyPlanet A FoodsEstablish Long-Term Collaboration

This collaboration serves both as a risk hedge for traditional chocolate giants and as an accelerator for the globalization of alternative-cocoa startups. Barry Callebaut (Barry Callebaut) Emphasizing that cocoa remains the core business, but in the face of market volatility, a diversified layout is needed. WithPlanet A The collaboration will leverage locally sourced sustainable materials to shorten the supply chain and reduce the environmental footprint, complementing the company’s broader sustainability strategy.

Planet AFounded in2021year, headquartered in Munich,Planet AofChoVivaThe brand uses crops such as sunflower seeds as raw materials to provide“Chocolate-like”experience. It has already8countries launched70Multiple Products.2024Completion by Year-End3000$10,000Bround of financing, and with the UKAldiExpand Cooperation.

Believer MeatsCultivated chicken has been approved by the U.S. Department of Agriculture

It is permitted to produce and sell cultured chicken meat at its facility in North Carolina, while also exporting to international markets.Believer MeatsThe first and only company to receive approval from the U.S. Department of AgricultureUSDAApproved large-scale cultured meat producer; the company has previously obtainedFDASafety clearances; these approvals collectively complete the company’s regulatory pathway for listing in the United States.

Believer MeatsThe plant located in Wilson County, North Carolina, covers an area of 200,000 square feet, is the world's largest cultured meat production base, with an annual production capacity of up to 12,000 Metric tons (approx. 2,600 10,000 pounds). Utilizing a proprietary cell culture process that combines centrifugal perfusion with a closed-loop medium regeneration system to enhance efficiency, reduce waste, and lower costs.

Japan’s food innovation ecosystem is maturing, with a significant surge in its share of financing.

2025Japan's share of agricultural and food technology investment in Asia in the year2024annual6.1%surge to13%, becoming the third-largest investor after India and China. New cross-industry partnerships have emerged across the entire value chain.

Biotalys# Stock Price Soars14%，EPAPlan to register the first protein-based biological fungicide.

Biotalysis the Flanders Institute for Biotechnology (VIB) in Belgium (VIB) incubated enterprise. The company relies on Agrobody Foundry™ Platform, leveraging an antibody-inspired protein library to screen for and develop biocontrol products targeting fungi, insects, and bacteria. The product registered under this initiative is namedEvoca, isBiotalysKey Pilot Cases for the Business Model. Previously, although the company had achieved R&D results, it did not yet have any marketed products.

Traditional R&D platforms for chemical and microbial food protection products typically require in-depth exploration and screening of a large number of potential new primary candidates during the research phase to identify those effective against specific insects, fungi, or microorganisms. In contrast, AGROBODY Foundry™ The platform is specifically designed to generate [agents/products] targeting insects, fungi, or microorganisms.AGROBODY™ Advantages of Bioactive Substances.AGROBODY™ Bioactive substances are designed to act on a given target through immune processes, which has the potential to provide a broad range of active protein-based bioactive agents with different modes of action in a single step.

The 5th Pilot-Scale Training Program in Biomanufacturing Makes a Grand Return!

November 26–27, Changshu, Jiangsu

Lock in 150 seats—first come, first served

This training session focuses on the core challenges of building pilot-scale production platforms, specially invitingXia Jianye, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences; Zang Hengchang, Shandong Universityand other leading experts, providing in-depth analysis of key technological modules such as high-throughput fermentation, separation and purification, and digitalization and intelligence.

Drawing on the proven experience from the first four editions and integrating real-world case studies from companies such as Bloomage Biotech and Morimatsu Life Sciences, this training program provides local governments and enterprises with a one-stop solution ranging from process scale-up to operational mechanisms.

Exclusive benefits, including instant discounts for group registrations and 50% off for returning students, are now available to help bridge the “valley of death” in biomanufacturing and seize first-mover advantage in this trillion-dollar industry.

30 secondsComplete a Short Survey

Add WeChat to claimResearch Report on the Biomanufacturing IndustryBig Gift Package