Sichuan University Announces Transfer of a TCM Patent for Oral Mucosal Ulcer Repair at RMB 100,000 Plus Royalties
Recently, Sichuan University announced the transformation of scientific and technological achievements through patent licensing, intending to license the patents“Extract of Traditional Chinese Medicine Compound for Oral Mucosa Repair, Its Extraction Method, Oral Mucosa Repair Preparation, and Its Preparation Method”Proposed transfer at a transaction price of RMB100,000 yuan plus sales commission。
The core transaction details of this patent areA Traditional Chinese Medicine Compound Solution for Oral Mucosal Lesions, Including Erosion, Congestion, and Ulceration, containing specific proportions ofExtracts of Traditional Chinese Medicine Formulas, Innovative Extraction Processes, and Two Optimized Dosage Forms. Its core technological innovations are concentrated in four areas:First, adhere to the TCM principle of “Jun-Chen-Zuo-Shi” compatibility., with Lithospermum and Aloe vera as the sovereign herbs, Scutellaria baicalensis and others as the minister herbs, and borneol and camphor as the guiding herbs, to achieve synergistic enhancement through multi-component collaboration;Second, oil immersion extraction is used to replace traditional water extraction., efficiently extract lipophilic active ingredients to enhance drug stability and mucosal affinity;Third, it offers dual dosage forms: gel and mouthwash., adapting to different patient use scenarios and enhancing drug adhesion and convenience;4. Establishing a multi-target mechanism of action, simultaneously addressing therapeutic needs for inflammation, infection, and tissue repair, with clinical efficacy and safety significantly superior to those of traditional formulations.
As a critical protective barrier within the oral cavity, the oral mucosa serves protective, sensory, and secretory functions, with its health status directly impacting essential physiological activities such as eating, swallowing, and daily communication. When the oral mucosa develops pathological changes—such as erosion, hyperemia, and ulceration—due to various triggers including infection, trauma, and inflammation, it not only causes significant pain but also severely diminishes patients' quality of life. Consequently, oral mucosal diseases have become one of the most prevalent clinical health issues.
Currently, clinical treatment regimens for such lesions are primarily categorized into three types:First, Western pharmaceutical preparations represented by glucocorticoids and steroids, although it can rapidly reduce inflammatory responses, long-term use is prone to causing side effects such as oral infections and immunosuppression, leading to poor medication adherence among patients;Second, traditional Chinese herbal preparations, which are mostly prepared using traditional techniques such as water decoction and extract preparation., issues such as insufficient release of active ingredients and poor formulation stability exist, leading to uncertain therapeutic efficacy;Third, traditional Chinese medicine gels and mouthwash products available on the market,These products typically rely on single herbal ingredients or simple compound formulas, lacking systematic research and scientifically designed formulations. Consequently, they demonstrate suboptimal efficacy in bacterial inhibition and mucosal repair, failing to meet patients’ core therapeutic needs.
Upon closer examination, current treatment regimens still exhibit significant shortcomings: the risk of side effects associated with corticosteroids limits their long-term use; traditional Chinese medicine preparations suffer from unstable efficacy and a lack of robust clinical data due to irrational formulation ratios and outdated extraction processes; and single dosage forms fail to meet personalized patient needs, such as varying lesion areas and usage preferences. In this context, there is an urgent clinical need for a novel therapeutic approach that combines safety, potency, and stability. Such a solution should reduce reliance on corticosteroids while achieving comprehensive anti-inflammatory, antibacterial, and tissue-repair effects through scientifically optimized formulations and advanced manufacturing processes, thereby providing safer and more effective treatment options for patients with oral mucosal lesions.
Grounded in Traditional Chinese Medicine (TCM) theory and supported by process innovation, this patented technology has established multidimensional core advantages and innovative breakthroughs, comprehensively addressing the pain points of traditional oral mucosal treatment formulations. In terms of formulation design, its innovationAdopting the Traditional Chinese Medicine principle of “Jun-Chen-Zuo-Shi” compatibility, thereby establishing a scientifically coordinated system of traditional Chinese medicine compound formulations.
With Lithospermum (25.0%) and Aloe Vera (35.6%) serving as the “monarch” ingredients, they deliver the core benefits of promoting blood circulation to remove stasis and moisturizing for regeneration, respectively. The combination of Scutellaria baicalensis, Phellodendron amurense, and Coptis chinensis—known as the “Three Huangs”—acts as the “minister” ingredients to enhance anti-inflammatory and antibacterial effects. Although Borneol and Camphor each account for only 0.1%, they serve as “guide” ingredients that significantly improve drug permeability. The precise formulation of 13 herbal ingredients achieves a multi-faceted synergistic effect of anti-inflammation, antibacterial action, and promotion of repair. Furthermore, all components are natural Chinese herbal medicines with strictly controlled heavy metal content, thereby avoiding the risks associated with long-term use of hormonal drugs. Skin irritation testing has confirmed the absence of adverse reactions such as erythema and edema, ensuring safety for long-term use.
In extraction technology, breaking through the limitations of traditional water extraction, innovativelyAdopting the Oil Maceration Extraction Method, withOlive OilUsing it as a solvent not only enables efficient dissolution of lipophilic active ingredients such as flavonoids and terpenes, but its inherent unsaturated fatty acids also enhance mucosal affinity. Combined with 15 days of sealed maceration at 20–25°C and 45–55% relative humidity, along with intermittent heating on days 1, 7, and 15, this process ensures high extraction efficiency while effectively preventing the degradation of heat-sensitive components. After refinement through 0.5–1.0 μm filtration equipment, the extract exhibits uniform texture and excellent stability. In a 14-day accelerated stability test at 54°C, the decline in active ingredient content was only 2.8%, supporting a shelf life of up to one year.
Achieved dual optimization and breakthroughs in dosage form and efficacy. LaunchingGelandMouthwashTwo formulations are available. The gel formulation, prepared with an extract, thickener, and deionized water in a 3:1:6 ratio, enhances drug adhesion to and retention time on the mucosa. The mouthwash formulation incorporates humectants and sweeteners to optimize the user experience, making it suitable for extensive mucosal lesions and meeting the individualized needs of different patients. Clinical studies have demonstrated that the overall efficacy rate of this preparation in the treatment of oral lichen planus is as high as95.99%, significantly superior to the 72.71% observed in the control group, with 20-minute bacteriostatic rates against Staphylococcus aureus and Escherichia coli of no less than 99.0% and 99.5%, respectively. Through multi-target mechanisms, including inhibition of inflammatory factors and promotion of growth factor expression, it achieves comprehensive therapeutic effects encompassing anti-inflammatory, antibacterial, and tissue repair actions.
Current Oral Mucosa Repair Market“Clear Essential Demand but Supply Imbalance”On one hand, conditions such as oral ulcers and lichen planus have high incidence rates and are prone to recurrence, creating an urgent patient demand for safe and effective treatment regimens. On the other hand, existing therapeutic options have significant limitations: Western hormonal drugs carry risks of side effects, while traditional Chinese medicine preparations suffer from inconsistent efficacy and outdated manufacturing processes, making them unable to adequately meet patients’ core needs.
Galla Chinensis TeaAs a traditional representative of Chinese herbal medicines for oral ulcers, this product is positioned as a daily adjunctive regimen primarily targeting mild, occasional oral ulcers triggered by "internal heat" (shanghuo). Its formulation centers on single-ingredient Galla Chinensis (Wubeizi), supplemented by green tea and honey to enhance efficacy. It does not follow the complex "monarch, minister, assistant, and envoy" compatibility logic of Traditional Chinese Medicine; instead, it relies solely on the simple synergy between Galla Chinensis’s astringent, detoxifying, and wound-healing properties, the tea polyphenols in green tea, and the reparative components of honey. The preparation adopts a traditional water decoction process, extracting water-soluble active ingredients through boiling. This method results in insufficient release of lipid-soluble components and easy degradation of heat-sensitive compounds, leading to limited utilization and stability of active ingredients. Available only as a liquid decoction for oral administration, the medication has limited direct contact and retention time on the oral mucosa, resulting in weak local protective and reparative effects on ulcer surfaces. Furthermore, Galla Chinensis contains tannins; excessive or long-term intake may irritate the gastric mucosa. It is prone to "retaining pathogenic factors" in patients with exogenous cough or damp-heat diarrhea, imposing clear restrictions on the eligible population. Overall, it can only provide adjunctive symptom relief, lacks suitability for severe lesions such as mucosal erosion and congestion, and is unsupported by robust clinical data.
Against this backdrop, there is an urgent market need for a novel product that combines high safety, potent efficacy, and reliability. This patent offers a precise solution to the aforementioned pain points, boasting extremely broad market prospects. From the demand side, the essential nature of treating mucosal diseases, coupled with their tendency for recurrent episodes, establishes a continuous and stable market foundation. From the supply side, the product features a scientifically formulated combination based on the traditional Chinese medicine (TCM) principle of “Jun-Chen-Zuo-Shi” (sovereign, minister, assistant, and envoy), utilizes an innovative oil-immersion extraction process, and is available in dual dosage forms: gel and mouthwash. This approach not only avoids the side effects associated with hormonal treatments but also addresses the efficacy limitations of traditional TCM products through multi-target synergistic action and robust clinical data, thereby creating a significant differentiated competitive advantage. Furthermore, as consumer health awareness rises, the demand for natural, safe, and highly effective pharmaceuticals is growing. This product aligns perfectly with this industry trend. It not only meets the urgent needs of a vast patient population but also has the potential to disrupt the existing market landscape, becoming a benchmark product in the field of oral mucosal repair. It serves as a high-quality example of the modernization of TCM, demonstrating immense market potential and industrial value.