Jilin University to Transfer Patent for Magnetic Targeting-Based Static Fixation Device for Stem Cell Guidance at RMB 20,000

Recently, Jilin University released a public notice on the transformation of scientific and technological achievements, proposing to transfer“A Magnetic Targeting-Based Static Fixation Device for Stem Cell Guidance”The relevant patents were assigned to Inner Mongolia Yinfeng Mengke Biotechnology Co., Ltd. for use, with a total transaction amount of RMB20,000 yuan. The inventor of this patented technology isWang Haotian and His Team。

This technology is a stem cell-guided static immobilization technique based on magnetic targeting, with its core beingProvides precise and stable magnetic field support for magnetically targeted stem cell therapy via a dedicated device, ultimately enhancing the therapeutic efficacy of magnetically targeted drug delivery., primarily applied inTargeted TherapyField.

Magnetic Targeting TechnologyWith advantages such as strong targeting capability and minimal damage to normal tissues, it has become an important development direction in the field of stem cell therapy, whilePrecise Control of External Magnetic FieldsIt directly affects the targeted accumulation efficiency and therapeutic efficacy of magnetic nanomedicines, serving as a core component in ensuring the safety and effectiveness of magnetic targeting therapy. In clinical treatments for conditions such as tumors and cardiovascular diseases, external magnetic fields are required to guide stem cells carrying magnetic nanoparticles precisely toward the lesion sites. However, if the angle and coverage area of the magnetic field do not match the lesion, it will not only reduce the targeted enrichment concentration of stem cells but may also lead to drug deposition in normal organs, causing adverse reactions and severely compromising treatment safety.

Such magnetic field modulation devices are key enabling tools for magnetically targeted stem cell therapy. For instance, in the treatment of solid tumors, lesions often have irregular shapes and are located deep within the body, requiring precise magnetic field coverage of the lesion area with stable angular orientation—a level of flexible adaptation that traditional equipment struggles to achieve. In the treatment of cardiovascular diseases, lesions are frequently situated at sites of vascular stenosis, demanding highly precise control over magnetic field strength; both excessive and insufficient field intensity can adversely affect the adhesion and engraftment efficacy of stem cells.

Therefore,Precise and Flexible Magnetic Field ControlIt is a core requirement for enhancing the efficacy of magnetic targeted therapy and an important prerequisite for promoting its clinical adoption.

Currently, traditional magnetic targeting devices used in clinical practice suffer from inherent structural design flaws and significant challenges during magnetic field modulation. Most conventional systems employ electromagnets with fixed specifications, capable only of simple horizontal movement. They lack the flexibility to adjust the vertical and lateral deflection angles of the magnetic field according to the lesion’s location, making it difficult to precisely align the magnetic field direction with the target lesion."Targeting Bias", significantly reducing treatment efficacy.

The magnetic field-generating components of certain devices have a fixed size and cannot adapt to lesions of varying dimensions. This results in an excessively large magnetic field coverage for small lesions, while failing to provide complete coverage for larger lesions.

Meanwhile, traditional devices lack stable angular fixation and intensity adjustment mechanisms. During treatment, the magnetic field is prone to deviation, and the precision of magnetic field intensity adjustment is insufficient, making it difficult to meet the personalized therapeutic needs of different drugs and patients. The overall assembly and disassembly of the equipment are cumbersome, hindering the replacement of magnetic field-generating components and complicating storage and transportation. Furthermore, the lack of hygienic protective design facilitates bacterial growth after prolonged use, posing a risk of cross-infection.

Furthermore, the bulky size and limited mobility of certain devices make them difficult to adapt to clinical scenarios across different departments, further restricting the clinical application of magnetic targeting technology. These issues have created an urgent clinical need for a novel magnetic field regulation device featuring multi-dimensional adjustment, flexible adaptability, and precise controllability, so as to resolve the current industry bottlenecks in magnetic targeted stem cell therapy.

Addressing the widespread issues associated with conventional magnetic targeting field devicesLimited angle adjustment, poor lesion adaptability, and cumbersome operation and maintenance...and other industry pain points, Jilin University has developed “A Magnetic Targeting-Based Static Fixation Device for Stem Cell Guidance,” which“Multi-Dimensional Precision Control + Modular Convenient Design”Centered on this core, an integrated solution that balances targeting precision with clinical efficiency has been developed through structural innovation and functional integration. This approach achieves systematic optimization in both magnetic field modulation capabilities and operational experience, significantly enhancing the safety and practicality of magnetically targeted stem cell therapy.

The core breakthrough of this device lies in the innovative construction ofFull-Dimensional Magnetic Field Control System, effectively addressing the issue of targeting deviations in traditional equipment caused by inaccurate magnetic field positioning and insufficient adaptability. Traditional devices typically support only horizontal movement, making it difficult to accommodate individualized variations in the spatial location, depth, and orientation of different lesions.

The present invention achieves this by“Height Adjustment + Bidirectional Angle Adjustment + Self-Rotating Positioning”Three-Tier Collaborative Regulatory Mechanism, achieving high-precision adaptation of the magnetic field to the lesion:

Height Adjustment:The motor body drives the rotation of the first lead screw, which in turn moves the carrier frame and electromagnetic induction coil assembly vertically to precisely match the depth of the lesion.

Bidirectional Angle Adjustment:The vertical and horizontal orientations are independently driven by electric linear actuators operating rack-and-pinion mechanisms, enabling angular deflection of the coil in both the vertical and horizontal planes to flexibly adapt to the spatial orientation of the lesion;

Fixed Spin Angle:By rotating the handle to drive the second lead screw, the arc-shaped clamping and positioning block is pushed to tightly secure the connecting rod, allowing for fine-tuning and reliable locking of the coil’s rotational angle around its axis, thereby ensuring that the magnetic field direction is precisely perpendicular to the lesion surface.

The synergistic action of the three-level regulation mechanism significantly enhances the matching degree and stability of magnetic field coverage, thereby improving the enrichment efficiency of magnetic stem cells in the target area and reducing the risk of drug deposition in non-target regions.

In terms of adaptability and ease of operation, the deviceAdopts a modular architecture and human-centered design, significantly enhancing clinical operational efficiency. To address the issues of fixed dimensions and difficulty in replacement associated with magnetic field generating components in conventional devices, the present invention employs a quick-release structure comprising fixing snap-fit posts and slots, in conjunction with a linkage unlocking mechanism consisting of sliders, locking rods, and springs. This design allows for the rapid replacement of electromagnetic induction coils of different specifications by simply pulling the unlocking handle, thereby flexibly adapting to the magnetic field coverage requirements for both minute and larger lesions.

The device body integrates universal wheels and a push handle, facilitating flexible transport between different clinical departments. A built-in storage compartment can hold disassembled components and spare coils, and is equipped with an ultraviolet sterilization lamp to achieve integrated storage and disinfection, effectively reducing the risk of cross-infection. The lifting adjustment base and the load-bearing frame adopt a bolted mounting plate structure, which is easy to assemble and disassemble, significantly reducing the operational burden on medical staff.

Furthermore, multiple detailed design features further enhance the device'sStructural Stability and Clinical Applicability：

First Limiting Sleeve and Second Limiting SleeveConstrain the travel range of the rack to ensure smooth and precise angular adjustment, thereby preventing magnetic field deviation during treatment;

Snap-fit Structure between the Shaft Seat and the Shaft Seat SlotEnhanced the connection rigidity between the connecting rod and the fixed locking post, ensuring stable coil positioning during prolonged treatment;

The storage compartment is equipped with a sealed door,Effective dust and stain resistance to protect internal components;

ApprovedAdjust the magnitude of the current supplied to the electromagnetic induction coil., enabling precise, on-demand adjustment of magnetic field strength to meet the requirements of different magnetic drug properties and personalized treatment plans for patients.

As the clinical translation of stem cell targeted therapy accelerates in fields such as oncology, cardiovascular disease, and neural repair, market demand for high-precision, adaptable, and user-friendly in vitro magnetic guidance devices continues to rise. Domestic and international enterprises and research institutions are carrying out technological iterations focused on pain points including magnetic field regulation, lesion adaptation, and clinical integration, forming"Clinical-Grade Cell Sorting Platform + Interventional Magnetic Navigation System + Research-Grade Magnetic Field Generation Device"The competitive landscape is parallel, with publicly available authoritative information on relevant product specifications, registration progress, and application cases.

MiltenyiAs the global benchmark in magnetic cell separation and targeted delivery, launchesCliniMACS Prodigy Fully Automated Cell Processing System, providing standardized solutions for the in vitro labeling and scalable manufacturing stages of stem cell therapy. This system employs MACS superparamagnetic microbead labeling technology and integrates the entire workflow, including cell sorting, washing, concentration, and formulation. It supports magnetic labeling and GMP-grade automated preparation of mesenchymal stem cells, hematopoietic stem cells, and other cell types, while closed sterile tubing reduces the risk of contamination. The system has obtained CE certification and FDA approval, and has been installed and applied clinically in multiple centers across China.

SiemensRelying onHigh-Field MRI Technology Introduces MAGNETOM Cima.X Ultra-High Gradient Magnetic Resonance System, providing integrated imaging-magnetic field support for magnetic resonance-guided targeted delivery of magnetic stem cells/nanomedicines. Its gradient field strength is approximately five times higher than that of conventional MRI, with a soft-tissue resolution of 0.4 mm, enabling real-time tracking of the in vivo distribution of magnetically labeled stem cells and supporting dynamic monitoring and dose optimization during the targeted delivery process. The system has been applied to precise navigation in neurosurgery and guidance for brain-computer interface surgeries, and preclinical validation of magnetically targeted drug delivery has been conducted. Relevant parameters and clinical cases have been disclosed at the China International Import Expo and academic conferences.