
At a time when global biomedical innovation is deeply integrated and cross-border collaboration is increasingly becoming the mainstream,“Going Global”From“Optional”Change to“Required Question”. However, in the face of capital cycle fluctuations, geopolitical challenges, and complex barriers to overseas clinical development, how to truly achieve“"Go Global, Land Locally"”, has become an imperative challenge that every Chinese innovative pharmaceutical company with global ambitions must confront.
Nowadays,Market forBDDeals are no longer made with blind buying; instead, stakeholders are scrutinizing the likelihood of performance behind down payments and assessing whether core equity pricing is reasonable, as pure pipeline narratives can no longer sustain valuations. This shift occurs amid capital cycle fluctuations, overseas clinical barriers, and a profound transition toward value-driven models.,NewcoModeEmerging as a New Pathway for Chinese Innovative Drugs to Go Global, Leveraging Its Flexible and Efficient Capital Structure and Risk-Sharing Mechanisms。How to Leverage the Resource Networks of Top-Tier Global Investment Firms? How to Mitigate Risks in Cross-Border Clinical Development“Acclimatization Issues”? How to pass throughNewcoHow to Maximize Value Through the Model?
4Month27Day,MPMin conjunction with its incubatedNewco- K2 Therapeutics,Held in Pudong, Shanghai【Boundless Innovation, Strategic Global Expansion:MPMCross-Border Collaboration and Clinical Strategy】Forum,Engage in In-Depth Dialogues with Top Global Investors, Clinical Development Experts, and Successful Entrepreneurs:
MPMAsian Investment Strategies from a Global Perspective——Decoding the Asian Investment Strategy of Top-Tier Global Investment Firms
New Cross-Border Clinical Collaboration Opportunities for Chinese Innovative Drugs: Deciphering the FDA Review Puzzle and Exploring Pathways for China-US Clinical Synergy
How K2 Helps Innovative Pharmaceutical Companies Go Global Quickly: From Deal Structure to Practical Implementation, Sharing Success Stories
This is not only a feast of ideas, but also a profound dialogue connecting East and West, and linking capital with innovation. Here, we go beyond“Discussion on Going Global”, more committed to building for you“Going Global”of the bridge!
Meeting Information
Time:2026Year4Month27Day(Monday)
Format: Closed-door meeting; invitation & review system (approx.100Person)
Location:UpHai·Pudong;Specific address will be sent after registration approval.
Co-organized by:MPM、K2 Therapeutics
Conference Organizer:BiGBiotech Innovation Club
Target Audience:Possessing a near-clinical or clinical-stage pipeline, or intending to expand into overseas marketsbiotechFounder/Executives;
FollowNewcoPartner at an Investment Firm Focused on Investment Models, Cross-Border Collaboration, and Innovation Opportunities
Registration QR Code
Closed-Door Meeting; Invitation Only (Limited to 100 Seats)
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Agenda
15:00 –15:20Registration & Welcome Tea Break
15:20-15:25 Forum Opening
Wu Jie Head of MPM APAC
15:25-15:40 MPM’s Development History and Investment Landscape(15min)
David Kolesky MPM Principal
15:40-15:55 MPM US Incubated Enterprise Sharing- OrnaDevelopment History(15min)
Frank Neumann MPM Entrepreneur Partner/Orna CMO
David Kolesky K2 Head of Corp Development
15:55 – 16:10 Asia Expansion Strategy & China Biopharma Outlook(15min)
Wu Jie MPMHead of Asia-Pacific Region
16:10-16:25 K2 Introduction(15min)
Binsen Li K2 Head of BD
16:25-17:25 Dialogue: K2 Newco Transaction(Each20min)
JinWang(K2 VP of Clinical Development)x David Miao(Adcoris Founder & CEO)
David Kolesky(K2 Head of Corp Development)x Renhong Tang(Simcere Zaiming Chairman &CEO)
Wu Jie(K2 CBO)x Haotian Wang(Higend Founder & CEO)
17:25-18:05 Panel: New Drug Development from a Global Perspective: Review Trends and Cross-Border Clinical Collaboration(40min)
Proposed Discussion Panelists:
Binsen Li K2 Head of BD(Moderator)
Samit HirawatK2 Independent Director
Frank NeumannK2 CMO
Pankaj Bhargava MPM Entrepreneur Partner, CEO of Ashibio
18:05-18:10 Closing Remarks(5min)
Ansbert Gadicke MPM Managing Partner/K2 Chairman
18:00– 20:00 Spring Reception
Guest Profile

Wu Jie K2 CBO
Wu Jie is the Head of APAC at MPM BioImpact, where she focuses exclusively on early-stage investment and company creation opportunities in the region.
Prior to joining MPM BioImpact, Wu Jie spent 16 years with Temasek and invested in healthcare companies across different geographies and subsectors, including Juno Therapeutics, Guardant Health and JW Therapeutics. She most recently served as Director of Life Sciences Investment at Temasek International in Singapore. Before that, she served as Director of Temasek’s China Investment Team.
Wu Jie received a M.S. degree in biotechnology from Johns Hopkins University, as well as both a M.S. and B.S. degree in engineering from Princeton University.

Frank Neumann K2 CMO
Prior to joining MPM BioImpact, Frank served as Senior Vice President and Global Head of Clinical Development at Kite, a Gilead Company. Previously Frank held positions as Chief Medical Officer at Verastem, Inc. (also known as Verastem Oncology) and Vice President, Head of Oncology Clinical Research at bluebird bio. In addition, he was clinical development head of global cell therapy approaches at Takeda Pharmaceuticals, where he also held various leadership roles of increasing prominence including global clinical lead and medical team lead for two distinct cancer therapies. Earlier in his career, Frank was a member of the oncology medical teams at AstraZeneca and Sanofi-Aventis.
Board certified in Hematology/Oncology, Internal Medicine and Palliative Care Medicine, Frank was a research scholar at the University of Texas MD Anderson Cancer Center and is currently an assistant professor at the Heinrich Heine University in Düsseldorf, Germany, where he received his M.D. He earned his Ph.D. from the Rheinische-Friedrich-Wilhelm University in Bonn, Germany.

Binsen Li K2 Head of BD
Dr. Binsen Li is a Principal of the investment team at MPM BioImpact Asia and is responsible for investment identification, due diligence and company creation opportunities in the APAC region.
Prior to joining MPM BioImpact, Binsen spent five years at Hillhouse Capital in New York, where he covered global healthcare investments across both the private and public markets.
Binsen earned his Ph.D. in Biochemistry, Molecular and Structural Biology from the University of California, Los Angeles. Earlier in his career, Binsen conducted neurobiology research at Harvard Medical School and received his B.A. in Biochemistry, Cellular and Molecular Biology from Connecticut College.

Haotian Wang Higend Founder & CEO
Haotian Wang is a graduate of Tsinghua University/PUMC. He has 10+ years of clinical medicine experience, and 8+ years clinical development, management and investment experience in healthcare industry.
As a founding team member of top tier China CRO and the core team member, he has supported 70+ IND submissions with successful approval (US/China), 150+ Phase I/IIa trials, 50+ Phase II/III studies, and 4 NDA/BLA approvals. He joined Legend Capital in 2021, served as a VP and director, focusing on early-stage biotech investment. Successively participated and worked as a core team member in the investment 10+ projects with a cumulative investment amount of about 100M USD, and providing post-investment support for 20+ projects, covering R&D translation and strategic planning.
He has hands-on experience in founding medical startups and CROs, with expertise in US/China regulatory systems and cross-cultural collaboration.

Jin Wang K2 VP of Clinical Development
Dr. Jin Wang is Vice President of Clinical Development at K2 Therapeutics, where she leads global development strategies and supports investment, search and evaluation, and business development initiatives. With 15 years of drug development experience, Dr. Wang has directed programs spanning early to late phases, including globally approved Tislelizumab and Zanidatamab.
Before joining K2, Dr. Wang held senior leadership roles across global biopharma. At Gilead Sciences, she led clinical development for the APAC region. As Chief Medical Officer at Ablaze Pharmaceuticals, she advanced a radiopharmaceutical pipeline to IND-enabling stages prior to its acquisition by Bristol Myers Squibb. At BeiGene, she directed global development strategies and cross-functional teams for major oncology assets.
Her earlier career includes impactful contributions at Eli Lilly and IQVIA, as well as hands-on patient care at Shanghai Changzheng Hospital.
Dr. Wang holds an MD and PhD in Medicine and is board-certified in Medical Oncology.

David Miao Adcoris Founder & CEO
Dr. Miao formerly served as the Principal Scientist at Enanta Pharmaceuticals, where he played a key role in the development of Viekira Pak, the FDA approved 2nd cure drug for Hepatitis C.
Formerly served as the Senior Director of Chemistry and a senior member of the research and development team at Ambrx Inc., promoted multiple products including hGH, FGF21, Arx788, in Phase II and Phase III clinical trials; developed a non-natural amino acid-based site-specific conjugation method as the ADC platform technology, which led to collaborations with Pfizer, Merck, Astellas, and BMS.
Throughout multiple successful entrepreneurial ventures, Dr. Miao has served as the founder and chief officer of several biotech companies such as Concortis Biosystems, Nanjing Levena/Levena (Suzhou), Zova Biopharmaceuticals, Sorrento Therapeutics, Imbioray Biopharma. Ph.D. in Chemistry at Peking University, Postdoctoral fellow at Vanderbilt University

David Kolesky K2 Head of Corp Development
Dr. David Kolesky is a Principal at MPM BioImpact. He is responsible for driving investments and company creation activities.
Before joining MPM BioImpact, David was a Principal at Flagship Pioneering, where he focused on conceiving, creating, and operating new bioplatform technology companies. David co-founded and helped launch several companies, notably Senda Biosciences and Montai Health, where he held key leadership roles at early stages of development including Chief Scientific Officer and Chief Innovation Officer at Montai, and Head of Platform at Senda. David has developed a wide range of scientific and technical experience by working across diverse platforms, including AI-enabled small molecule discovery, programmable delivery of genomic medicines, and cell & tissue engineering.
David received his Ph.D. in Engineering Sciences from Harvard University and conducted a postdoctoral fellowship at the Wyss Institute for Biologically Inspired Engineering. His work has been published in top journals and he is co-inventor of several issued patents. David has received numerous awards, including the National Inventor’s Hall of Fame Collegiate Inventor Prize.
A native of South Florida, David received his B.S in Materials Science and Engineering from the University of Florida.

Samit Hirawat K2 Independent Director
Samit Hirawat, M.D., serves as an independent member of the Board of Directors at K2 Therapeutics.
Most recently, Samit Hirawat, M.D., served as Chief Medical Officer, Executive Vice President, and Head of Global Drug Development at Bristol Myers Squibb, where he oversaw the drug development development portfolio and advanced multiple transformative therapies across therapeutic areas and modalities to registration trials and approvals globally. Prior to that, he spent more than a decade at Novartis Pharmaceuticals in roles of increasing strategic responsibility, leading to his position as Executive Vice President and Head of Oncology Development. Earlier in his career, Samit held clinical development positions at PTC Therapeutics and Pharmacia/Pfizer.
Samit Hirawat, M.D., earned his Bachelor of Medicine and Bachelor of Surgery (MBBS) from Sawai Man Singh Medical College in Jaipur, India. He completed his Internal Medicine residency and Medical Oncology fellowship at North Shore University Hospital. He has published more than 150 peer-reviewed manuscripts and abstracts across therapeutic areas.

Pankaj Bhargava CEO of Ashibio
Pankaj has over 20 years of drug development and senior management experience. He is an Entrepreneur Partner at MPM BioImpact Capital where he founded āshibio. Previously he served as the Oncology Therapeutic Area Head at Gilead Sciences. He has also held executive positions at multiple biotech companies during his career, including Sanofi and Dicerna Pharmaceuticals, where he led development programs for oncology and rare genetic diseases. Pankaj earned his M.D. from the University of Delhi and completed fellowship training in medical oncology and clinical pharmacology at Georgetown University and NIH, including a visiting fellowship at FDA. He is an alumnus of Program for Leadership Development at Harvard Business School and has held academic faculty positions at Harvard Medical School, Dana-Farber Cancer Institute and University of California, San Francisco.

Ansbert GadickeMPM Managing Partner & K2 Executive Chairman
Dr. Ansbert Gadicke is the Managing Partner of MPM BioImpact. Ansbert founded MPM Capital in 1992 as a biotech venture capital firm and later its affiliate BioImpact Capital for private/public funds. He is the driving force at MPM BioImpact behind building leading companies such as BioMarin Pharmaceuticals (NASDAQ: BMRN), Idenix Pharmaceuticals (acquired by Merck & Co.), Mitobridge (acquired by Astellas), TriNetX, and Pharmasset (acquired by Gilead Sciences) and, more recently, Cullinan Therapeutics (NASDAQ: CGEM), ElevateBio and Orna Therapeutics. MPM BioImpact believes that these companies, in which Ansbert was the lead investor and served on the Boards of Directors, are some of the biggest successes in biotech – companies that ultimately result in helping thousands of patients live longer and vastly improved lives. For example, Sovaldi, developed by Pharmasset, was the first cure for Hepatitis C, the most successful product launch in the pharmaceutical industry and has today cured over 6 million patients of Hepatitis. Prior to founding MPM, Ansbert was at The Boston Consulting Group in their Boston office.
Ansbert’s commitment to drug discovery and curing disease inspires his work both within and outside of MPM BioImpact. In recognition of MPM’s novel work to finance and build companies which may have a significant impact on cancer care and cures globally, Ansbert is a recipient of the 2017 Global Oncology Visionary Award. He is a member of the Harvard Medical School Board of Fellows and the Research Advisory Council of Massachusetts General Hospital.
Ansbert received an M.D. from J.W. Goethe University in Frankfurt and held research positions at the Whitehead Institute for Biomedical Research at the Massachusetts Institute of Technology and the Biochemistry Department at Harvard University. While at the German Cancer Research Center, he focused on HPV16 and 18 in Professor Harald zur Hausen’s group (Nobel Laureate in Physiology or Medicine, 2008). Ansbert has published in leading scientific journals such as Nature and Cell.
Introduction to the Organizer & Undertaker
MPM BioImpact
MPM BioImpact is a globally leading biopharmaceutical investment firm with over 30 years of specialized experience in founding and investing in innovative enterprises, dedicated to delivering transformative therapies for patients.
MPM BioImpactThey are the creators of the enterprise. Possessing a professional team of entrepreneurial partners with deep expertise in new drug R&D, intellectual property, clinical strategy, and commercialization, these are the key factors for successfully building a company.
MPM BioImpaCT conclusionCombining MPM CAPITAL®’s 30-plus years of successful experience in biopharmaceutical venture capital, BioImpact’s expertise in impact investing, and over a decade of secondary market investment experience. With assets under management totaling $3.5 billion, the portfolio encompasses early-stage venture capital funds and small- to mid-cap hedge funds.
As one of the most influential associations in China’s biopharmaceutical sector, the Biomedical Innovation Group (BiG) is a non-profit membership organization that brings together more than 600 industry elites, including academicians, clinical experts, pharmaceutical company founders, executives, and investors, while also operating a professional media platform.
BiG’s core mission is to build a bridge for an innovation ecosystem, facilitating the translation of academic achievements into clinical applications and industrial commercialization, empowering breakthroughs in life sciences and the upgrading of the health industry, and accelerating the globalization of Chinese new drugs. Through a diverse array of activities—including annual summits, quarterly forums, closed-door seminars, Young CEO Forums, cloud-based sharing sessions, and the dissemination of high-value content—BiG has fostered collaborative innovation among academia, industry, and research institutions, establishing itself as a central hub in the development of the new drug R&D ecosystem.