The Future Is Here, No More Waiting | Thermo Fisher's Automated NGS System Genexus Officially Launched

Recently, Thermo Fisher Scientific officially launched the Ion Torrent™ Genexus™ Purification System in the United States for the global market. The launch of the Genexus Purification System has given rise to the first fully automated, end-to-end NGS integrated system in the high-throughput sequencing industry—the Ion Torrent™ Genexus™ High-Throughput Sequencing System—truly achieving a seamless "sample-in to report-out" workflow.

The Genexus system is an accessible next-generation sequencing (NGS) platform for molecular testing and translational research institutions that truly realizes the “All in One, One for All” philosophy. By seamlessly integrating high-precision industrial manufacturing with cutting-edge life sciences, it features unparalleled all-in-one integration, exceptional automation, minimal manual intervention, remarkably fast testing speed, and outstanding result accuracy, propelling the NGS industry to new heights of greater precision, simplicity, intelligence, and advancement!

The GeneXus Purification System is compact yet powerful. Powered by MagMAX technology, it features pre-loaded reagents and consumables that are simple and easy to use. Requiring only a single manual step, the system enables automated extraction, purification, and quantification of DNA and RNA from diverse sample types. It delivers rapid processing, flexible throughput, and a fully automated workflow that streamlines quality control, yielding high-quality nucleic acid end products with excellent reproducibility and broad compatibility.

It is well known that next-generation sequencing (NGS) technology is highly powerful, yet it is widely regarded as a "four-too" product: too difficult, too expensive, too time-consuming, and too complex. NGS demands highly specialized personnel, involves complex operations and lengthy workflows that are both time-consuming and labor-intensive, presents significant challenges in data interpretation, requires long-term professional study and continuous training, and entails high comprehensive implementation costs. These practical realities constitute the greatest obstacles hindering the widespread application of NGS technology and its accessibility to the general public.

Confronted with these challenges, the Thermo Fisher Ion Torrent platform rises to the occasion, transforming numerous highly demanding impossibilities into achievable realities. Tracing the evolution of the Ion Torrent technology platform, from the launch of the Ion PGM™ system through successive iterative upgrades to the Ion Proton™ and Ion GeneStudio™ S5 series, it has consistently delivered higher sequencing throughput, enhanced automation, increasingly comprehensive solutions, broader application scenarios, and a continuously expanding repository of application experience and data. Built upon steadfast dedication and profound accumulation of expertise, the Genexus system emerges as the culmination of over a decade of continuous advancement and relentless innovation. Specifically engineered to address the aforementioned pervasive challenges within the NGS industry, it represents the latest breakthrough solution.

The Genexus System consists of the Genexus Purification System, the Genexus Integrated Sequencer, and Genexus`Software`composed of, innovatively integrating all wet-lab and dry-lab workflows for NGS, along with the end-to-end hardware systems andSoftwareThe system is fully integrated.

Genexus System Workflow

With just two instruments, the entire workflow—from sample nucleic acid extraction, purification, quantification, and dilution, to library preparation, template preparation, and sequencing, followed by data quality control, analysis, variant calling, annotation, and report generation—can be fully automated. The entire process requires only two manual steps, significantly reducing manual intervention.

Innovatively integrating nucleic acid extraction, purification, quantification, liquid handling, visual monitoring, temperature control, library preparation, template preparation, next-generation sequencing instruments, basic analysis software, and data and reporting servers into a single unified platform, this system consolidates numerous hardware and software components to lead industry advancement.

A simple, user-friendly system that requires only 2 steps and 15 minutes of hands-on operation and setup for the entire workflow. All reagents are preloaded, and consumables are barcoded for immediate use upon unpacking. An onboard intelligent visual tracking and feedback system monitors consumable status in real time, featuring built-in error-proofing safeguards. The entire process is controlled by intuitive software that requires only a quick 4-step configuration. With a flexible throughput of 1–32 samples, the complete NGS workflow can be completed in as little as one day, offering exceptional flexibility and efficiency. Equipped with a “smart brain” and “capable limbs,” the Geneexus system enables even personnel without prior NGS experience to rapidly initiate NGS projects.

Wide range of applications, suitable for``Tumor``, Microbiology and Infectious Diseases, ReproductionGeneticsSpecialized testing across various fields, as well as translational research applications in a broader range of areas. Leveraging the core Ion AmpliSeq™ technology, it provides a one-stop solution for the flexible and customized design of diverse genetic testing panels for humans and other species.

Compatible with a wide range of sample types, including FFPE, whole blood, plasma, fresh tissue, frozen tissue, and peripheral blood leukocytes.

Fast testing speed: the final mutation test report is available in as little as one day.

Currently, more than 10,000 original research articles utilizing Ion Torrent technology have been published, and numerous domestic and international studies and practical applications have consistently demonstrated the accuracy and reliability of Ion Torrent technology and the Ion AmpliSeq method.

 

This latest system will also be showcased at this year's China International Import Expo (CIIE). You are welcome to visit Hall 8.1.Medical Devicesand at the Thermo Fisher Scientific booth in the Medical & Healthcare Exhibition Area, experience the Genexus system up close!

The Genexus system enables NGS users to save time, reduce operational burdens, minimize effort, lower costs, and optimize personnel and space utilization. It promotes the widespread adoption of NGS precision medicine testing across more molecular diagnostic and translational research institutions, facilitating localized testing and expanding applications into broader and deeper fields. In China, Thermo Fisher Scientific consistently upholds its corporate mission to "enable our customers to make the world healthier, cleaner, and safer." By leveraging smarter tools to deliver more precise test results in less time, it accelerates the rapid formulation of diagnostic and treatment protocols, adding greater momentum to safeguard life! (Bioon)

ClickLink, learn more about the Genexus system!

*For research use only. Not for use inDiagnosisIntended Use