Nature: Pigs died 6 hours ago
Post-Systemic "Revival"August 3,NaturePublished an article titled“Cellular recovery after prolonged warm ischaemia of the whole body”The study developed a system called OrgnEx, which was tested on pigs that had been dead for an hour after their hearts stopped. The system allowed oxygen to circulate within the pigs, preserved tissue integrity, reduced cell death, and restored specific molecular and cellular processes in multiple vital organs, as well as restored circulation throughout the body. This significant research achievement could potentially help extend the health of human organs during surgery and be used for preserving tissues and organs, increasing the availability of transplantable organs.Without eggs, sperm, and uterus,
Stem Cells Successfully Cultivate Embryo
On August 1, scientists at the Weizmann Institute of Science in IsraelCellAn article published reported that they successfully used stem cells to cultivate a synthetic embryo model of mice outside the uterus, a process that does not require the combination of sperm and egg. This method opens up new perspectives for studying how stem cells form various organs in developing embryos and makes it possible to use synthetic embryo models to generate tissues and organs for transplantation.
AbbVie's ADC Therapy Initiates Phase 3 Clinical Trial
For Non-Small Cell Lung CancerRecently, the China Drug Clinical Trial Registration and Information Disclosure Platform showed that AbbVie has initiated an international multicenter (including China) Phase 3 clinical trial to evaluate the efficacy and safety of telisotuzumab vedotin (ABBV-399) in previously treated non-squamous non-small cell lung cancer patients. Public data indicates that ABBV-399 is an investigational antibody-drug conjugate (ADC) targeting c-Met. The drug has received Breakthrough Therapy Designation from the U.S. FDA for the treatment of non-small cell lung cancer.KissingCan trigger herpes simplex virus infectionSmall blisters on the mouth are often referred to as "fever blisters" or "cold sores." This is a viral infection, and the culprit is "Herpes Simplex Virus Type 1" (HSV-1).It is usually hidden in the sensory nerves of the face.In the neurons, when psychological or physiological stress occurs, they may be activated and cause trouble.That's right, it's about piling bubbles on the edge of your lips.This virus is estimated to have infected two-thirds of the global population at a minimum.How it became one of the most widely spread infectious diseases worldwide remains an unsolved mystery and is extremely difficult to track.5,000 years agoThen appearedHSV-1 strain,This is very likely related to the kissing culture that humans have developed.
Regeneron Terminates COVID-19 Cocktail
Four Clinical Studies on TherapyRecently, Regeneron terminated four clinical trials of the COVID-19 neutralizing antibody Ronapreve (REGEN-COV, casirivimab + imdevimab).The study includes:Phase IIa Clinical Trial to Evaluate the Efficacy and Safety of Subcutaneous REGEN-COV in High-Risk COVID-19 Patients Under 12 Years Old (Started on September 13, 2021);Phase Ia Clinical Trial to Evaluate the Efficacy and Safety of REGEN-COV in Pediatric Patients Hospitalized with COVID-19 (Started on December 16, 2021);Phase III Clinical Trial to Evaluate the Efficacy of REGEN-COV in Preventing COVID-19 in Immunocompromised Adolescents and Adults (Started on October 25, 2021);Clinical trial to evaluate the effectiveness of REGEN-COV in treating outpatients with COVID-19 (started on June 16, 2020).According to the update on the official website of the clinical trial, "Emerging SARS-CoV-2 variants impacting susceptibility to study drug"These four items were the reasons for the clinical termination."
