Johnson & Johnson Submits Clinical Application in China for Ophthalmic Gene Therapy JNJ-81201887 Targeting Geographic Atrophy in AMD

On May 17, Johnson & Johnson's gene therapy JNJ-81201887 for the treatment of ophthalmic diseases had its clinical application accepted by the National Medical Products Administration in China.

Patients with age-related macular degeneration (AMD) typically have lower levels of CD59, a protein that protects the retina from damage caused by the body's natural immune response "complement" system. Geographic atrophy is a late progressive form of AMD. In geographic atrophy, the overactive complement destroys cells in the central area of the retina, the macula (responsible for central vision and seeing details), leading to the ongoing development of blindness.

JNJ-81201887 (JNJ-1887, AAVCAGsCD59) is an investigational one-time gene therapy for the treatment of geographic atrophy. JNJ-1887 aims to increase the expression of soluble CD59 (sCD59) to protect retinal cells, thereby slowing and preventing disease progression.

The Phase IIb PARASOL study of JNJ-81201887 for the treatment of adults aged 60 and above with advanced dry AMD geographic atrophy is currently recruiting patients. JNJ-1887 has received Fast Track designation from the U.S. FDA and Advanced Therapy Medicinal Product (ATMP) designation from the European Medicines Agency (EMA).

JNJ-81201887 was initially developed by Hemera Biosciences, and on December 2, 2020, Johnson & Johnson acquired the development rights to this candidate therapy.

Copyright © 2023 PHARMCUBE. All Rights Reserved.

Welcome to forward, share, and reasonably cite. When citing, please clearly indicate the source of the article; if you need to reproduce it, please leave a message to the WeChat Official Account's backend or send a message, and include the name and ID of the official account.

Disclaimer: The information in this WeChat article is for general reference only and should not be used directly as decision-making content. PharmaCube assumes no responsibility for any loss incurred by any party due to the use of the content herein.

Exciting Preview

Online Live Streaming & Offline Salon

↑ Click to scan the QR code and reserve a live broadcast ↑