GSK's BCMA-Targeted ADC Blenrep Shows Superior PFS Over Standard Therapy in Phase 3 DREAMM-7 Trial

▎Edited by the WuXi AppTec content team

Today, GSK announced positive topline results from the interim efficacy analysis of the Phase 3 clinical trial DREAMM-7 program. The results showed that the antibody-drug conjugate belantamab mafodotin, as a second-line therapy, met the primary endpoint of progression-free survival (PFS) in treating relapsed or refractory multiple myeloma.Belantamab mafodotin in combination with bortezomib and dexamethasone (BorDex) significantly extended the time without disease progression or death compared to the current standard treatment regimen for this condition.In addition, during this analysis, it was observed thatSignificant and Clinically Meaningful Overall Survival (OS) Trend, the trial is still ongoing to further monitor OS outcomes.

In the DREAMM-7 trial, 494 participants were randomly assigned in a 1:1 ratio to receive either belantamab mafodotin in combination with BorDex or daratumumab in combination with BorDex. All participants had received at least one prior line of therapy for multiple myeloma and had demonstrated disease progression during or after their most recent treatment.

The primary endpoint of the trial was progression-free survival as determined by an independent review committee. Key secondary endpoints included overall survival, duration of response, etc.Belantamab mafodotinIt is an antibody-drug conjugate composed of a monoclonal antibody targeting B-cell maturation antigen (BCMA) linked to the cytotoxic payload auristatin F through a non-cleavable linker.

The safety and tolerability of the Belantamab mafodotin regimen are consistent with the known safety profile of the drugs in the combination therapy. These interim analysis results will be presented at an upcoming scientific conference and shared with regulatory authorities.

[1] GSK announces positive results from DREAMM-7 head-to-head phase III trial for Blenrep in relapsed/refractory multiple myelomahttps://www.gsk.com/en-gb/media/press-releases/gsk-announces-positive-results-from-dreamm-7-head-to-head-phase-iii-trial-for-blenrep/

.data_color_scheme_dark{--weui-ORANGERED: #ff6146;--weui-BG-0: #111;--weui-BG-1: #1e1e1e;--weui-BG-2: #191919;--weui-BG-3: #202020;--weui-BG-4: #404040;--weui-BG-5: #2c2c2c;--weui-FG-0: rgba(255, 255, 255, .8);--weui-FG-HALF: rgba(255, 255, 255, .6);--weui-FG-1: rgba(255, 255, 255, .5);--weui-FG-2: rgba(255, 255, 255, .3);--weui-FG-3: rgba(255, 255, 255, .1);--weui-FG-4: rgba(255, 255, 255, .15);--weui-FG-5: rgba(255, 255, 255, .1);--weui-RED: #fa5151;--weui-REDORANGE: #ff6146;--weui-ORANGE: #c87d2f;--weui-YELLOW: #cc9c00;--weui-GREEN: #74a800;--weui-LIGHTGREEN: #3eb575;--weui-BRAND: #07c160;--weui-BLUE: #10aeff;--weui-INDIGO: #1196ff;--weui-PURPLE: #8183ff;--weui-WHITE: rgba(255, 255, 255, .8);--weui-LINK: #7d90a9;--weui-TEXTGREEN: #259c5c;--weui-FG: #fff;--weui-BG: #000;--weui-TAG-TEXT-RED: rgba(250, 81, 81, .6);--weui-TAG-BACKGROUND-RED: rgba(250, 81, 81, .1);--weui-TAG-TEXT-ORANGE: rgba(250, 157, 59, .6);--weui-TAG-BACKGROUND-ORANGE: rgba(250, 157, 59, .1);--weui-TAG-TEXT-GREEN: rgba(6, 174, 86, .6);--weui-TAG-BACKGROUND-GREEN: rgba(6, 174, 86, .1);--weui-TAG-TEXT-BLUE: rgba(16, 174, 255, .6);--weui-TAG-BACKGROUND-BLUE: rgba(16, 174, 255, .1);--weui-TAG-TEXT-BLACK: rgba(255, 255, 255, .5);--weui-TAG-BACKGROUND-BLACK: rgba(255, 255, 255, .05)}.data_color_scheme_dark{--weui-BTN-ACTIVE-MASK: rgba(255, 255, 255, .1)}.data_color_scheme_dark{--weui-BTN-DEFAULT-ACTIVE-BG: rgba(255, 255, 255, .126)}.data_color_scheme_dark{--weui-DIALOG-LINE-COLOR: rgba(255, 255, 255, .1)}.data_color_scheme_dark{--weui-BG-COLOR-ACTIVE: #373737}.data_color_scheme_dark{--weui-BG-6: rgba(255, 255, 255, .1);--weui-ACTIVE-MASK: rgba(255, 255, 255, .1)}.rich_media_content{color:#000000e5;font-size:17px;font-size:var(--articleFontsize);overflow:hidden;text-align:justify}.rich_media_content{color:#ffffffa6;color:var(--weui-FG-HALF)}.rich_media_content{position:relative;z-index:0}.wxw-img{vertical-align:bottom}.h5_image_link{position:relative;display:inline-block;vertical-align:bottom;-webkit-user-select:none;-ms-user-select:none;user-select:none}.h5_image_link:before,.h5_image_link:after{content:"";position:absolute;top:8px;right:8px;width:20px;height:20px;display:-ms-flexbox;display:flex;-ms-flex-align:center;align-items:center;-ms-flex-pack:center;justify-content:center;z-index:1}.h5_image_link:before{background:#5f5f5f80;-webkit-backdrop-filter:blur(20px);backdrop-filter:blur(20px);border-radius:100%}.h5_image_link:after{-webkit-mask:url(data:image/svg+xml;charset=utf8;base64,PHN2ZyB4bWxucz0naHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmcnIHdpZHRoPScxNicgaGVpZ2h0PScxNicgdmlld0JveD0nMCAwIDE2IDE2Jz4gIDxnIGZpbGw9JyM1NzZCOTUnPiAgICA8cGF0aCBkPSdNOC41NjYgNy40MzRsLTEuOTgtMS45OC0uNzU0Ljc1NSAxLjI1NyAxLjI1N0gyLjMzM3YxLjA2N0g3LjA5TDUuODMyIDkuNzlsLjc1NC43NTUgMS45OC0xLjk4YS44LjggMCAwIDAgMC0xLjEzMnonLz4gICAgPHBhdGggZD0nTTQuMzMzIDExLjhIMy4yNjd2MS4wNjdhLjguOCAwIDAgMCAuNzk3LjhoNy44MDVhLjguOCAwIDAgMCAuNzk4LS43OThWMy4xMzFhLjc5OS43OTkgMCAwIDAtLjc5OC0uNzk4SDQuMDY0YS44LjggMCAwIDAtLjc5Ny44VjQuMmgxLjA2NnYtLjhIMTEuNnY5LjJINC4zMzN2LS44eicvPiAgPC9nPjwvc3ZnPg==) no-repeat 50% 50%;mask:url(data:image/svg+xml;charset=utf8;base64,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) no-repeat 50% 50%;-webkit-mask-size:14px;mask-size:14px;background:#fff}.h5_image_link:empty{display:none}.rich_media_content p{clear:both;min-height:1em}td p{margin:0;padding:0}@media(prefers-color-scheme:dark){body:not([data-weui-theme=light]) .rich_media_content img:not(.wx_img_placeholder){filter:brightness(.8)}}body,.wx-root,page{--weui-BTN-HEIGHT: 48;--weui-BTN-HEIGHT-MEDIUM: 40;--weui-BTN-HEIGHT-SMALL: 32}body,.wx-root{--weui-FG-1: rgba(0, 0, 0, .55);--weui-ORANGERED: #ff6146;--weui-BG-0: #ededed;--weui-BG-1: #f7f7f7;--weui-BG-2: #fff;--weui-BG-3: #f7f7f7;--weui-BG-4: #4c4c4c;--weui-BG-5: #fff;--weui-FG-0: rgba(0, 0, 0, .9);--weui-FG-HALF: rgba(0, 0, 0, .9);--weui-FG-1: rgba(0, 0, 0, .5);--weui-FG-2: rgba(0, 0, 0, .3);--weui-FG-3: rgba(0, 0, 0, .1);--weui-FG-4: rgba(0, 0, 0, .15);--weui-FG-5: rgba(0, 0, 0, .05);--weui-RED: #fa5151;--weui-REDORANGE: #ff6146;--weui-ORANGE: #fa9d3b;--weui-YELLOW: #ffc300;--weui-GREEN: #91d300;--weui-LIGHTGREEN: #95ec69;--weui-BRAND: #07c160;--weui-BLUE: #10aeff;--weui-INDIGO: #1485ee;--weui-PURPLE: #6467f0;--weui-WHITE: #fff;--weui-LINK: #576b95;--weui-TEXTGREEN: #06ae56;--weui-FG: #000;--weui-BG: #fff;--weui-TAG-TEXT-RED: rgba(250, 81, 81, .6);--weui-TAG-BACKGROUND-RED: rgba(250, 81, 81, .1);--weui-TAG-TEXT-ORANGE: #fa9d3b;--weui-TAG-BACKGROUND-ORANGE: rgba(250, 157, 59, .1);--weui-TAG-TEXT-GREEN: #06ae56;--weui-TAG-BACKGROUND-GREEN: rgba(6, 174, 86, .1);--weui-TAG-TEXT-BLUE: #10aeff;--weui-TAG-BACKGROUND-BLUE: rgba(16, 174, 255, .1);--weui-TAG-TEXT-BLACK: rgba(0, 0, 0, .5);--weui-TAG-BACKGROUND-BLACK: rgba(0, 0, 0, .05)}body,.wx-root{--weui-BG-6: rgba(0, 0, 0, .05);--weui-ACTIVE-MASK: rgba(0, 0, 0, .05)}@media screen and (min-width:1024px){body:not(.pages_skin_pc){background:#191919;background:var(--weui-BG-2)}}@media(prefers-color-scheme:dark){body:not([data-weui-theme=light]).my_comment_empty_data{background-color:#111}}.wx-root,body{--weui-BTN-ACTIVE-MASK: rgba(0, 0, 0, .1)}.wx-root,body{--weui-BTN-DEFAULT-ACTIVE-BG: #e6e6e6}.wx-root,body{--weui-DIALOG-LINE-COLOR: rgba(0, 0, 0, .1)}.wx-root,body{--weui-BG-COLOR-ACTIVE: #ececec}@media(prefers-color-scheme:dark){.wx-root:not([data-weui-theme=light]),body:not([data-weui-theme=light]){--appmsgExtra-BG: #121212}}@media(prefers-color-scheme:dark){.wx-root:not([data-weui-theme=light]),body:not([data-weui-theme=light]){--weui-ORANGERED: #ff6146;--weui-BG-0: #111;--weui-BG-1: #1e1e1e;--weui-BG-2: #191919;--weui-BG-3: #202020;--weui-BG-4: #404040;--weui-BG-5: #2c2c2c;--weui-FG-0: rgba(255, 255, 255, .8);--weui-FG-HALF: rgba(255, 255, 255, .6);--weui-FG-1: rgba(255, 255, 255, .5);--weui-FG-2: rgba(255, 255, 255, .3);--weui-FG-3: rgba(255, 255, 255, .1);--weui-FG-4: rgba(255, 255, 255, .15);--weui-FG-5: rgba(255, 255, 255, .1);--weui-RED: #fa5151;--weui-REDORANGE: #ff6146;--weui-ORANGE: #c87d2f;--weui-YELLOW: #cc9c00;--weui-GREEN: #74a800;--weui-LIGHTGREEN: #3eb575;--weui-BRAND: #07c160;--weui-BLUE: #10aeff;--weui-INDIGO: #1196ff;--weui-PURPLE: #8183ff;--weui-WHITE: rgba(255, 255, 255, .8);--weui-LINK: #7d90a9;--weui-TEXTGREEN: #259c5c;--weui-FG: #fff;--weui-BG: #000;--weui-TAG-TEXT-RED: rgba(250, 81, 81, .6);--weui-TAG-BACKGROUND-RED: rgba(250, 81, 81, .1);--weui-TAG-TEXT-ORANGE: rgba(250, 157, 59, .6);--weui-TAG-BACKGROUND-ORANGE: rgba(250, 157, 59, .1);--weui-TAG-TEXT-GREEN: rgba(6, 174, 86, .6);--weui-TAG-BACKGROUND-GREEN: rgba(6, 174, 86, .1);--weui-TAG-TEXT-BLUE: rgba(16, 174, 255, .6);--weui-TAG-BACKGROUND-BLUE: rgba(16, 174, 255, .1);--weui-TAG-TEXT-BLACK: rgba(255, 255, 255, .5);--weui-TAG-BACKGROUND-BLACK: rgba(255, 255, 255, .05)}}@media(prefers-color-scheme:dark){.wx-root:not([data-weui-theme=light]),body:not([data-weui-theme=light]){--weui-BTN-ACTIVE-MASK: rgba(255, 255, 255, .1)}}@media(prefers-color-scheme:dark){.wx-root:not([data-weui-theme=light]),body:not([data-weui-theme=light]){--weui-BTN-DEFAULT-ACTIVE-BG: rgba(255, 255, 255, .126)}}@media(prefers-color-scheme:dark){.wx-root:not([data-weui-theme=light]),body:not([data-weui-theme=light]){--weui-DIALOG-LINE-COLOR: rgba(255, 255, 255, .1)}}@media(prefers-color-scheme:dark){.wx-root:not([data-weui-theme=light]),body:not([data-weui-theme=light]){--weui-BG-COLOR-ACTIVE: #373737}}@media(prefers-color-scheme:dark){.wx-root:not([data-weui-theme=light]),body:not([data-weui-theme=light]){--weui-BG-6: rgba(255, 255, 255, .1);--weui-ACTIVE-MASK: rgba(255, 255, 255, .1)}}@media(prefers-color-scheme:dark){.wx-root:not([data-weui-theme=light]),body:not([data-weui-theme=light]){--discussInput-BG: rgba(255, 255, 255, .03)}}h1,h2,h3,h4,h5,h6{font-weight:400;font-size:16px}a{color:#576b95;text-decoration:none;-webkit-tap-highlight-color:#0000;-webkit-user-drag:none}a{color:#7d90a9;color:var(--weui-LINK)}a,button{cursor:pointer}@media screen and (min-width:1024px){body:not(.pages_skin_pc) :root{--appmsgPageGap: 20px}}:root{--articleFontsize: 17px}:root{--sab: env(safe-area-inset-bottom)}:root{--wxBorderAvatarRatio: 3}:root{--discussPageGap: 20px}:root{--appmsgPageGap: 20px}*{margin:0;padding:0}.rich_media_content *{max-width:100%!important;box-sizing:border-box!important;-webkit-box-sizing:border-box!important;word-wrap:break-word!important}