Yongheng Yaoyao Intelligent Technology: Pioneering Digital Life Chemistry Services and Biochemical New Materials Innovation

The integrated development of the digital economy and the real economy has become an important means for China to enhance industrial competitiveness, as well as a crucial path to building a modern industrial system on the road to Chinese-style modernization.

In recent years, the Chinese government has issued a series of policies in the fields of data centers, cloud computing, and other digital economy sectors. These policies outline China's blueprint for digital transformation, covering key areas such as building modern data infrastructure, promoting cloud computing technology, developing artificial intelligence, and protecting data security.

YONG HENG YAO YAO, established in 2021, focuses on【Digital Service Business】——1. Life Chemistry Nuclear Library (Database, Knowledge Base, Expert Pool), 2. Bio-cloud Service Platform (Research Assistance Platform, Industrial Assistance Platform, Customized Service Platform), 3. Molecular Dynamics Simulator (Super MD, Supramolecular Database, Block Trading Center).【Biochemical New Materials Business】——1. Supramolecular environmentally friendly new materials (formaldehyde adsorption, xylene adsorption, VOC adsorption), 2. Biomedical aesthetic materials (high-end medical aesthetics raw materials, advanced medical aesthetics technology), 3. Biomedical material preparation (exosome and its lyophilized powder preparation, suspension and adherent cell preparation) and other strategic industries that are strongly encouraged and supported by the state, have achieved rapid development relying on the "company's innovation team" and become a pioneer enterprise in China's bioeconomy industry innovation, as specifically reflected below:

• YONG HENG YAO YAO has become a National High-tech Enterprise, a newly listed company on the Ningbo Equity Exchange (listing code 784236), an enterprise establishing the Ningbo Doctoral Innovation Station, an innovative small and medium-sized enterprise in Ningbo City, a science and technology-oriented small and medium-sized enterprise in Zhejiang Province and Ningbo City, a national-level science and technology-oriented small and medium-sized enterprise, an enterprise engineering (technology) center in Zhenhai District, a practice and internship base for college students in Zhenhai District, an Alibaba Product Ecosystem Integration Certified Enterprise, and a member enterprise of the Photosynthesis Organization.

• A total of 3 authorized invention patents (12 accepted and disclosed), 11 authorized utility model patents, 15 software copyrights, and 5 national trademarks. The total number of authorized intellectual properties amounts to 34.

• Successfully introduced more than 50 high-caliber engineering talents, attracted quality venture capital investors, achieved equity financing of 39 million yuan, and received continuous revolving financial support from banks.

YONG HENG YAO YAO actively responds to the national call and has established a "one body, two wings" strategic layout. "One body" refers to "digital innovation" as the core, while "two wings" are "digital technology innovation services" in software and "new materials technology innovation business" in hardware. This time, VCBeat interviewed the company's project team regarding YONG HENG YAO YAO’s layout in the life chemistry field.

Laboratory Entrepreneurship Scenario

The project team consists of technical personnel with PhD, master's, and bachelor's degrees from 985, 211, Double First-Class universities, as well as returned overseas students and engineers with years of engineering experience. They have participated in major national scientific research projects such as the State Council's National Key Projects, the Ministry of Science and Technology's International Cooperation Projects, the NDRC's Industrial Upgrade Projects, the National Natural Science Foundation, and the 863 Program. The team includes key members of Zhejiang Province's New Generation Mobile Internet Client Software Key Scientific Innovation Team. They possess entrepreneurial experience and expertise in scientific research, technology development, project management, and personnel organization. They have extensive experience in digital technology, predictive algorithm technology, GPT application technology, automation technology, and industrialization.

YONG HENG YAO YAO's independently developed "Life Chemistry Digital Technology Software Service Platform" consists of a core life chemistry library, a bio-cloud software platform, and a molecular dynamics software platform. It provides full-process coverage across various fields such as biopharmaceuticals/new materials research and development, computational simulation, project progress management, and laboratory management. By integrating technologies like big data, artificial intelligence, cloud computing, and digital twin, the platform achieves automation, standardization, and multi-technology synergy, and innovatively addresses the non-digital pain points of traditional laboratories.

The project team told VCBeat that the core of laboratory digital transformation is to support laboratories in forming valuable digital assets—trustworthy data—and ultimately empower the value creation process. Based on this, YONG HENG YAO YAO launched the "Life Chemistry Digital Technology Software Service Platform," advancing laboratory operations from the manual "agricultural" era to the automated and digitized "industrial" era, and finally to the latest "intelligent" era. This improves work efficiency, reduces errors, ensures compliance, cuts costs, and enhances effectiveness for academic institutions and R&D enterprises in the biopharmaceutical field, solving long-standing problems in traditional laboratories.

Digital laboratory services include information resource sharing, full-process paperlessness, automated data collection, intelligent analysis, etc., which can help laboratories improve quality management methods, standardize laboratory management processes, achieve big data analysis and application in laboratories, and enhance user satisfaction with the services. These numerous advantages make laboratory digitalization a trend, but "digital transformation" is a completely new proposition for many laboratories. Due to a lack of mature experience, the transformation process is fraught with challenges.

Life Chemistry Digital Technology Software Service Platform

"The Core Library of Life Chemistry" includes the Life Chemistry Database, the Life Chemistry Knowledge Base, and the Life Chemistry Expert Database. It is the world's first comprehensive database that integrates compounds, proteins, genes, and natural products, with data volume reaching PB levels, successfully benchmarking against internationally renowned databases. Functions include similarity compound search, virtual screening, and more. Additionally, it features proprietary functionalities such as ADMET, chemical retrosynthesis, AI-powered intelligent assistant, and a knowledge graph of life chemistry, transforming experimental data from mere results into foundational drivers for innovative research and development.

In order to address the "chokepoint" risk of potential data supply disruptions from overseas, YONG HENG YAO YAO's "Core Library of Life Chemistry" is grounded in China’s national conditions. By localizing data, ensuring autonomy in derived data, and translating data into Chinese, it tackles the issue of foreign data supply disruptions at its source. The platform not only incorporates all authoritative online data but also adds innovative data through autonomous information extraction. The data volume is comprehensive and rich, with diverse dimensions, leading globally, and will continue to expand.

At the same time, the proportion of independent creation is high, with open-source integrated data accounting for only 40%, AI information extraction data making up 40%, manually collected data comprising 10%, and user-uploaded and experiment-generated data each accounting for 5%. Multilingual content enables global users to get started quickly and can meet the needs of various stages of biopharmaceutical R&D and production.

Considering data security issues, YONG HENG YAO YAO stores hundreds of billions of data on local servers, achieving localized data security and preventing data loss. The platform has been in trial operation since 2023 and will gradually replace international authoritative websites between 2024 and 2025.

YONG HENG YAO YAO's "BioCloud Software Platform," including the research platform, industrial platform, and customization platform, is the world’s first AI + cloud platform to simultaneously cover various fields such as biopharmaceutical R&D, project progress management, and laboratory management. It features laboratory digitization, molecular biology-assisted design, data analysis, AI biological design software, AI-assisted decision-making, technical support services, and advanced customization services, meeting the needs of biopharmaceutical R&D, project progress management, and laboratory management.

Combined with its exclusive core library of life chemistry, it makes it possible to acquire high-quality, high-throughput, high-standard, and low-cost big data for drug research and development, also ushers in the "digital intelligence" era, bringing groundbreaking changes to the field of drug discovery.

The highlight of this platform lies not only in applying artificial intelligence and computational biology to drug research and development, significantly shortening R&D time and reducing costs. Through digital products such as the AI natural product synthesis system, AI compound screening system, and intelligent validation system, it compresses the time for laboratory development by 40%-50%, reduces costs by about half, and increases success rates by 30%-40%, achieving cost reduction and efficiency improvement while accelerating R&D progress.

Moreover, laboratories adopting digital technology will facilitate the strengthening of data resource management and integration for academic institutions and R&D enterprises in the biopharmaceutical field by digitally integrating laboratory-related system resources. This will help medical laboratories evolve from "rapid expansion" to "meticulous development," improving the work efficiency of R&D laboratories.

In recent years, the application of exosomes in disease diagnosis and treatment has received widespread attention. On May 10, 2022, the National Development and Reform Commission issued the "14th Five-Year Plan for Bioeconomy Development." "Exosome therapy" was included in the national economic development plan for the first time. In the column "Bioeconomic Innovation Capability Enhancement Project" under the section "Construction of Key Common Biotechnology Innovation Platforms," "exosome therapeutic products" were mentioned again, highlighting the importance of exosomes.

However, the fluid environment where exosomes exist is complex, and there are significant differences in size, morphology, and biochemical characteristics. Moreover, the process of isolating and extracting exosomes is cumbersome. Therefore, how to effectively isolate exosomes for further research has always been a challenge in this field.

"New Materials Technology Innovation Business" is the hardware business of YONG HENG YAO YAO, consisting of three parts: supramolecular environmentally friendly new materials, medical cosmetology new materials, and exosome preparation technology. Since supramolecular environmentally friendly new materials involve the industrial and new energy fields, they will not be included in this discussion for now.

YONG HENG YAO YAO has developed, through years of dedicated efforts, a high-throughput exosome purification technology platform with independent intellectual property rights, a large-scale exosome lyophilized powder freeze-drying process platform, and customized directional services, offering products and services including biomedical beauty raw materials, medical aesthetics intermediates, high-purity lyophilized powder, low-purity lyophilized powder, and other customized solutions.

It is reported that the YONG HENG YAO YAO exosome R&D team has collaborated with multiple medical aesthetics enterprises, medical institutions, and biopharmaceutical companies in China to complete the technical research and development and industrial production of high-purity exosome lyophilized powder and low-purity exosome lyophilized powder. Among these, the high-purity exosome lyophilized powder undergoes a 4-layer deep filtration system and customized freeze-drying technology, achieving an exosome purity of over 99%, with a freeze-dried storage duration of up to more than 2 years.

In addition, relying on profound technical accumulation and equipment development experience, YONG HENG YAO YAO can also OEM high-end medical devices according to customer needs.

YONG HENG YAO YAO Intellectual Property

In terms of commercialization, the company's automated equipment and exosome lyophilized powder have already achieved profitability. In the future, YONG HENG YAO YAO's R&D team will continue to focus on the original value of exosome purification technology and further enhance the development of exosome lyophilized powder, aiming to provide more efficient, convenient, and reliable exosome solutions for additional biomedicine, medical institutions, and biopharmaceutical enterprises.

Striving forward on a new journey, forging ahead with courage to write a new chapter. Looking back at the just-passed 2023, YONG HENG YAO YAO has made significant progress in all its businesses – the core life chemistry library was successfully developed, the first phase of the bio-cloud software platform R&D was completed, the "ExoT IP" platform for exosome biomedicine was initially developed, innovative products for molecular dynamics simulators were completed, and the development of supramolecular cage eco-friendly new materials was largely finished.

There is no doubt that a new round of technological revolution and industrial transformation is reshaping the global innovation landscape and restructuring the global economic framework. Digital technology and the digital economy, as the forefront of this global technological revolution and industrial transformation, are increasingly integrating into all fields and processes of socioeconomic development. The digital transformation of the global economy is now an inevitable trend.

The project team, composed of young tech professionals from the post-90s and post-00s generations, is highly motivated. From focusing on life chemistry to balancing "software and hardware," they are building a digital technology software service platform for life chemistry and advancing new materials technology innovation. The team continuously responds enthusiastically to national calls, contributing their youth to China’s biochemistry and industrial fields.

The entrepreneurial journey, while full of challenges, is also brimming with hope. The company's team shows us through their actions that technology, difficulties, and funding are not obstacles to entrepreneurship—where there is a dream, every point in life can be a starting point.

With a vast journey of ten thousand miles ahead, the time for striving is now. We also look forward to YONG HENG YAO YAO's rise to prominence, rooted in China and facing the globe, delivering "Chinese wisdom" and telling the "Chinese story" on the world stage of life chemistry and industry, bridging the gap between technology and commercialization through digitalization and original innovation.

References:"YONG HENG YAO YAO 'Life Chemistry Digital Technology Software Service Platform' Goes Online, Leading the Exploration Path of Laboratory Digitization"