MSD to Acquire Harpoon Therapeutics for $680 Million to Expand Oncology Pipeline with Clinical-Stage Multispecific Antibody Therapies

▎Edited by the WuXi AppTec content team

MSD and Harpoon Therapeutics Announce Definitive Agreement

According to the agreement, Merck & Co., Inc. will spend approximately $680 million to acquire Harpoon Therapeutics, Inc. through its subsidiary. Merck will obtain a series of T-cell engager therapies under research, including HPN328, a DLL3-targeted T-cell engager in Phase 1/2 clinical development, further expanding its oncology R&D pipeline.

Harpoon Therapeutics has made significant progress in the field of cancer immunotherapy, developing a series of innovative T-cell engagers. These achievements are based on the company's proprietary tri-specific T-cell Activating Construct (TriTAC) platform, an engineered protein technology designed to direct the patient’s own immune cells to attack tumor cells. Additionally, Harpoon's ProTriTAC platform applies the prodrug concept to the TriTAC platform, creating a T-cell engager that remains inactive until it reaches the tumor site.

▲Harpoon Therapeutics' main therapy under development (Image Source:

Harpoon Therapeutics Official Website）

Harpoon’s lead candidate drug HPN328 is a T-cell engager targeting DLL3. DLL3 is an inhibitory Notch ligand that is highly expressed in small cell lung cancer (SCLC) and neuroendocrine tumors.HPN328 is currently undergoing a Phase 1/2 clinical trial to evaluate the safety, tolerability, and pharmacokinetics of HPN328 monotherapy in patients with advanced cancers expressing DLL3. The study is also assessing the efficacy of HPN328 in combination with atezolizumab for the treatment of SCLC patients. In October 2023, Harpoon Therapeutics announced positive interim data on the tolerability and response of HPN328 in certain SCLC and neuroendocrine tumor patients.

This acquisition also includes other pipeline candidates, such as HPN217, which targets B-cell maturation antigen (BCMA) and is currently in Phase 1 clinical trials for the treatment of patients with relapsed/refractory multiple myeloma. Harpoon's pipeline also includes several preclinical candidates, such as HPN601, a conditionally activated drug targeting epithelial cell adhesion molecule (EpCAM), for the treatment of patients with EpCAM-expressing tumors.

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