Biokin:Received an $800 million upfront payment from Bristol-Myers Squibb for the BL-B01D1 development and commercialization licensing agreement.CareRay Digital Medical Technology Co., Ltd.:On March 8, 2024, the company, through the Shanghai Stock Exchange trading system, repurchased 100,000 shares of the company for the first time via centralized bidding. The repurchased shares account for 0.11% of the company's total share capital of 88,129,027 shares. The highest price for the repurchase was RMB 13.64 per share, and the lowest price was RMB 13.33 per share. The total amount of funds paid was RMB 1,352,331.03.Hao Outop:The board of directors received a letter from Mr. JOHN LI, one of the actual controllers, chairman, and general manager of the company, on March 6, 2024, titled "A Proposal for HOB Biotech Group Co., Ltd. to Repurchase the Company's Shares." Based on confidence in the company's future development, recognition of the company's value, and fulfilling social responsibilities, Mr. JOHN LI proposed that the company use its own funds to repurchase part of the issued Renminbi ordinary shares (A-shares) through the Shanghai Stock Exchange trading system via centralized bidding.Daily Pharmaceutical FocusXingqi Pharmaceutical:Received the "Drug Registration Certificate" for Atropine Sulfate Eye Drops issued by the National Medical Products Administration.Dirui Industrial Co.,Ltd.:Recently obtained one "Medical Device Change Registration Document" and two "Medical Device Registration Certificates" issued by the National Medical Products Administration, thirteen "Medical Device Change Registration (Filing) Documents" and one "Medical Device Registration Certificate" issued by the Jilin Province Medical Products Administration, and two "Class I Medical Device Filing Information Forms" issued by the Changchun Market Supervision Administration.TIANYU PHARM:TIANYU PHARM's subsidiary, Linhai Tianyu, underwent an on-site GMP inspection by the European Directorate for the Quality of Medicines & Healthcare ("EDQM") for the Active Pharmaceutical Ingredient CEP (Certificate of Suitability to the European Pharmacopoeia) from October 18 to October 20, 2023. Recently, the company received the inspection certificate issued by EDQM, and the inspection was successfully passed.Amoy Diagnostics Co. LTD.:Completed the relevant change registration procedures and obtained the renewed Business License issued by the Xiamen Market Supervision Administration.
Daily Pharmaceutical News
Johnson & Johnson Completes Acquisition of Ambrx Biopharma
Recently, Johnson & Johnson announced the successful completion of its acquisition of Ambrx Biopharma, Inc. Ambrx Biopharma is a clinical-stage biopharmaceutical company with a proprietary synthetic biology technology platform for designing and developing next-generation ADCs. The acquisition was completed in an all-cash merger transaction, with a total equity value of approximately $2 billion (approximately 14.3 billion RMB at the time), and a net amount of $1.9 billion after deducting the estimated acquired cash, as announced on January 8, 2024. This transaction will be considered a corporate merger.
Human Natural Protein Can Form Virus-like Capsids and Be Engineered as mRNA Delivery VectorsOn March 5, 2024, Professor Zhang Feng's team published a research paper titled: Human paraneoplastic antigen Ma2 (PNMA2) forms icosahedral capsids that can be engineered for mRNA delivery in the Proceedings of the National Academy of Sciences (PNAS). The study developed an mRNA delivery method based on the human PNMA2 protein, which naturally forms icosahedral capsids in human cells. Engineered variants of PNMA2 (ePNMA2) can encapsulate mRNA in vitro and deliver it to host cells.Science | Amazing BioSUM Sticker: Can Monitor Life-Threatening Postoperative Complications in Real TimeRecently, a latest study published in the journal *Science* has brought a breakthrough. A joint research team developed a novel sticker material that monitors pH changes in organ tissues in real time through ultrasound, indicating anastomotic leakage. The authors refer to this biodegradable, shape-adaptive, and ultrasound-readable material structure as "BioSUM." Professor John Rogers from Northwestern University, Researcher Heling Wang currently at Tsinghua University, and Professor Chet Hammill from Washington University in St. Louis are the co-corresponding authors of the paper.Among anastomotic leaks from different sites, gastric fluid is acidic due to the presence of gastric acid; pancreatic fluid is alkaline; and the leaked fluid from the intestines is weakly acidic with a pH slightly lower than that of normal tissue. If a "pH reagent" readable by ultrasound could be placed inside the body, timely monitoring of anastomotic leaks could be achieved through changes in pH values. BioSUM can reveal fluid leakage within the body with high sensitivity and specificity, enabling doctors to intervene earlier. After the patient recovers, the biocompatible, bioabsorbable patch will disappear on its own without the need for surgical removal. The research team has also developed software capable of automatically analyzing images, making it convenient for radiologists to use.
Industry Communication and Exchange
