Next Bridge Hydrocarbons, Inc. Announces Filing of S-1 Registration Statement for Innovative Hip Implant – Ultra-Crosslinked Gradient Polyethylene Acetabular Liner

# Artificial JointMarket Size

Artificial Joint Replacement SurgeryIs a treatmentEnd-stage Severe Osteoarthritis and Advanced Knee Joint DiseaseA very mature and effective surgery,It is one of the common joint replacement surgeries. The hip joint has a high usage rate in humans, so it is relatively more prone to degenerative diseases compared to other joints.

Artificial JointMainly refers to the treatment of diseases such as osteoarthritis, rheumatoid arthritis, femoral head necrosis, and severe fractures around the joints.Orthopedic Implants. The expected service life of joint products is typically over twenty years, withMainly focusing on hip and knee joints。

According to the "Survey on the Prevalence of Primary Osteoarthritis in People Over 40 Years Old in China," the incidence rate of osteoarthritisIncrease with ageThe prevalence rates of primary osteoarthritis in people aged 40-49, 50-59, 60-69, and over 70 are 30.1%, 48.7%, 62.2%, and 62.0%, respectively. Osteoarthritis is more common in the elderly. In recent years, the aging trend of the population in China has intensified.The market size of joint-related consumables is expected to grow rapidly.。

In the first year of China's national joint consumables procurement in 2021, a total of 538,000 sets were purchased. The average price reductions for hip and knee joints reached 80% and 84%, respectively. With the significant decrease in artificial joint product prices, a surge in market demand is expected.

Based on the number of artificial joint replacement surgeries performed from 2013 to 2018, the number of hip and knee replacement surgeries in China from 2019 to 2025 was estimated respectively. Combined with the market prices from national procurement, the estimation was calculated.The scale of China's artificial joint market is approximately 6.955 billion yuan in 2025..(Data source:MDCLOUD）

Hip joint products generally include acetabular cups, femoral heads, liners, and femoral stems. The main innovation points in structural design are relatively concentrated in the acetabular cup, femoral stem, and the cooperation mechanism between the acetabular cup and liner. One of the medium to long-term problems that needs to be solved in this cooperation mechanism isImplantationObjectWear. After the prosthesis is implanted into the human body, it needs to be accompanied by movement for decades, and the friction interfaceThe failure means the failure of the prosthesis, requiring revision surgery. To address the wear issue, b-ONE has developed a hip prosthesis - cross-linked gradient polyethylene acetabular liner.

Ultra-high cross-linked gradient polyethylene uses gradient cross-linking technology, introducing an ultra-high equivalent irradiation cross-linking degree on the critical friction interface surface layer of artificial joints, thereby achieving superior performance.Wear Resistance; As the material depth increases, the cross-linking degree gradually decreases, maintaining the mechanical toughness and strength of the material. Studies have shown that the wear performance of this material in water is higher than that of several highly cross-linked polyethylene components and close to the wear data of ceramic components. Meanwhile,Mechanical toughness is superior to ceramics, making it possible to design and manufacture a new type of ultra-thin, ultra-durable artificial joint prosthesis.

# b-ONE Ortho

In 2021,b-ONE Ortho Acquires Shanghai Shengshi Medical Device Technology Co., Ltd.(hereinafter referred to as b-ONE Ortho). b-ONE Ortho has a relatively complete product portfolio in the fields of limb joint replacement, oncology, and personalized custom joints, and has a long-term collaboration with Dai Kerong, an academician of the Chinese Academy of Engineering. In the 2021 National Artificial Joint Centralized Procurement in China, b-ONE Ortho's hip and knee joint products were selected. After the completion of the acquisition, b-ONE Ortho became a rare domestic provider capable of offering...Total Joint Replacement Solutions for LimbsThe enterprise.

b-ONE's product line includesHip, Knee, Shoulder, Ankle, Wrist, Tumor, and Customized Artificial Joint Replacement Systems, andMemory Alloy Fracture Fixation SolutionAmong them, several product lines are among the few domestically produced brands in China that have obtained registration certificates, such as wrist joint and ankle joint replacement systems. For instance, the ankle joint replacement system, paired with the self-developed Insight+ personalized surgical osteotomy system, has been used in surgical procedures at multiple large tertiary hospitals in China.

In the field of shoulder jointsb-ONE can provide a complete shoulder joint solution, including an integrated half shoulder joint, a standard shoulder replacement system, and a reverse shoulder replacement system.In the field of oncology and personalized custom implantsBenefiting from the years of technical accumulation by Shengshi Medical, b-ONE can currently provide a complete solution, including limb-sparing solutions for bone tumors in various parts of the limbs such as the pelvis, femur, tibia, calcaneus, humerus, scapula, phalanges, and ulna and radius.

In the commercialization of joint implantsAccording to Wang Junwen, founder and CEO of b-ONE, since the official commercialization of b-ONE products in early 2019 in China, they have covered hundreds of hospitals.Both hip and knee products have been selected in the national centralized procurement of artificial joints in China., with the qualifications for hospital admission, is expected to expand to more hospitals; in the international market, it has currently entered more than ten countries including Southeast Asia, Latin America, and Africa, and is preparing to expand into markets such as Japan, South Korea, and the Middle East.

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