May 17,According to the CDE official website, Merck KGaA's Class 1 new drugM9140 for InjectionClinical trial application accepted. According to publicly available data, M9140 is an anti-CEACAM5 ADC。

M9140 is MerckDeveloped using proprietary technologyAn antibody-drug conjugate (ADC) targeting cancer cells expressing carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5).
MerckThe ADC pipeline is led by the targeting of CEACAM5 M9140,The drug'sThe drug has a wide therapeutic window and is stable in the bloodstream, and its combination with DDR inhibitors can produce a synergistic effect.The cytotoxic payload in M9140 is a topoisomerase 1 (TOP1) inhibitor, which prevents DNA repair. Currently,M9140 is in Phase I clinical trials for colorectal cancer.Merck Partial Pipeline
Summary
CEACAM5 is a glycoprotein that is overexpressed in pancreatic cancer, gastrointestinal cancer, and lung cancer. ADCs are novel anti-cancer drugs that can directly deliver cytotoxic payloads to cancer cells and kill them.Based on the principle of CEA-targeted drug delivery, in recent yearsCEA, as one of the commonly used tumor markers in clinical practice, has entered the ADC track.。ChinaA total of 90 pipelines targeting CEACAM5 have been developed globally, currently inClinical Stage: 10 Pipeline Projects.
Table Source:Medicine Monster, Stop

Cell Line Product Inquiry
Submission | Business Cooperation
Reprint | Join the Communication GroupClick "Pharmaceutical Research Network" below to follow more exciting content.