Affluence Medical Enters Strategic Collaboration with Edwards Lifesciences for Kalios Adjustable Mitral Annuloplasty Ring

Jul 13, 2024 22:15 CST Updated 22:15

Affluent Medical

Minimally Invasive Implant Developer

Edwards Lifesciences

Cardiovascular Surgical Equipment Provider

Affluence MedicalAnnouncement of Agreement with Edwards for Unrestricted Adjustment of Mitral Annuloplasty RingKaliosAndCooperation Agreement on Mitral Valve Technology.According to the terms of the agreementAffluence MedicalWill receive a prepayment of 15 million euros from Edwards.

This cooperation agreement includes three parts:

Part 1: Edwards pays 5 million euros in advance for the exclusive option of Kephalios (Kephalios is a wholly-owned subsidiary of Affluent Medical and the owner of Kalios technology).

Part Two:Edwards Prepayment5 million euros,ObtainAffluence MedicalBionicGlobal Non-Exclusive License for Intellectual Property of Mitral Valve Replacement Technology in Cardiac Surgery Only.Affluent Medical RetainedAll patent rights for transcatheter valves, includingEpyGON Technology.

Part Two：Edwards Prepayment€5 million for the acquisition partAffluent Medical equity (approximately 9.21%).

Executive Evaluation

"We are proud to sign these agreements with the global leader in structural heart innovation.We look forward to Edwards becoming a shareholder of our company.Edwards' strong global market influence and commercial infrastructure make our product Kalios potentially helpful for doctors and their patients worldwide, while leveraging our technology to build a solid partnership for Kalios and surgical mitral valves. Affluence MedicalWill continue to develop its transcatheter mitral valve Epygon and artificial urinary sphincter Artus for incontinence.”

--- Sébastien Ladet Affluent Medical ChiefExecutive

Edwards Lifesciences is the leader in the field of structural heart disease, with product offerings spanning aortic, mitral, and tricuspid valves, as well as pulmonary valves. It boasts the most extensive product portfolio among all participants in the valve disease market. Particularly in the TAVR and TTVR fields, Edwards Lifesciences maintains a leading edge over its competitors.In the field of transcatheter mitral valve, Edwards Lifesciences has the replacement product EVOQUE, the edge-to-edge repair product PASCAL, and more. However, for Edwards, which aspires to become the absolute leader in this field, this is not enough. To solidify its leadership position in the valve sector, it has made a difficult decision to...Intensive Care Business. Recapitalizing funds to focus on the development of innovative products in the valve field. Upon saleAfter one month of intensive care business, Edwards began to enhance its valve business.Affluence MedicalFeatured Mitral Valve Annuloplasty Repair TechniquesKaliosBecoming Edwards' First Choice, WithEdge-to-EdgeRepair ProductsPASCAL complements and enhances competitiveness with Abbott.

In the future, Edwards will continue to strengthen its valve product line, after all$4.2 Billion Cash Can Do a Lot.

Kalios

KaliosIt is an artificial mitral valve annuloplasty ring, which differs from traditional mitral valve rings in that it can be percutaneously and repeatedly adjusted at any time after implantation, without stopping the heart, to adapt to the patient’s actual needs, thereby avoiding the need for a second surgery.

KaliosByConfiguration at implants and Kalios fit two parts.

Configuration at implants

Including a lead (thin tube) that is implanted in the patient's body, with its distal end positioned subcutaneously near the clavicle for easy access to the device (e.g., pacemaker).

Kalios fit

Consists of three balloon catheters and three connecting tubes.

KaliosCan be implanted as a traditional "Carpentier" ring for normalMitral Annuloplasty。In the case of recurrent mitral regurgitation, even months or years after the initial surgery,Configuration at implantsWhen fully stable with inward cell growth, it can still be adjusted as needed.Kalios fit，TherebyThe leaflets are more tightly sealed, preventing regurgitation.

Kalios Demonstration

Affluent Medical

Affluent MedicalCommitted to providing the world's best available therapies to address unmet needs in broad and significant diseases so far. Millions of patients around the world are suffering and consistently unable to find the optimal treatment.

Affluent MedicalCommitted to developing breakthrough medical devices using novel approaches. A deep understanding of physiology aids in our design of a new generation of minimally invasive prosthetics, aiming to mimic anatomical structures and restore the natural physiology of critical functions.

Affluent MedicalBesidesKaliosIn addition, its mitral valve---EpygonIt is also very outstanding.Specifically, you can learn about "The Only TMVR Preserving Natural Left Atrial "Blood Flow Vortex" --- Epygon”。

Affluent Medical is a very good target in the mitral valve field for companies or institutions in China.