Javelin: The First Non-Balloon Intravascular Lithotripsy Catheter Designed to Tackle CTO Lesions

Nov 03, 2024 22:15 CST Updated 22:15

Johnson & Johnson

Healthcare Product Manufacturers, Health Service Providers

Johnson & Johnson (Shockwave) Unveils Next-Gen Peripheral IVL Catheter at TCT 2024 ConferenceJavelin。JavelinUnlike the previous balloon-based IVL catheter developed by Johnson & Johnson, this is the first IVL catheter without a balloon.

AndByChrist Hospital'sJ.D. CorlAt the TCT ConferenceIntroductionJavelinCase of Treating Peripheral Lesions. An 85-year-old elderly woman suffers fromThe patient has a severe calcification (CTO) lesion in the left anterior tibial artery, with a length of 92mm. AfterJavelinAfter treatment, not only was the patency of the left anterior tibial artery achieved, but the minimum lumen diameter (MLD) on angiography also reached 1.9mm.

Peripheral Artery Disease (PAD): A type of atherosclerosis where fats deposit along the arterial walls, causing narrowing and obstructive lesions, primarily affecting the arteries of the lower limbs and feet.

PAD is a common vascular disease, affecting more than 20 million people in the United States and 202 million people worldwide.

When an artery is blocked by a blood clot, preventing blood from flowing to the lower limbs and feet, PAD will appear. Blockage can lead to poor blood circulation, pain while walking, and changes in skin color.

It is estimated thatPADUp to 40% of patients may have complete vascular occlusion, and these patients often suffer from disabling disabilities or severe limb ischemia. Today's Crossing CTO techniques are very challenging and can easily lead to surgical failure, prolonged operation time, increased radiation exposure for both patients and doctors, higher perioperative complications, and repeated interventions.

As the pioneer of shock wave technology for treating vascular calcification, Johnson & Johnson also hopes toShock WaveTechnology for TreatmentComplete OcclusionBlood vessels, but the previously developed balloon-based IVL catheter clearly could not fulfill this wish. To this end, Johnson & Johnson developed a balloon-free IVL catheter based on the previous IVL catheter---Javelin。JavelinAchieve the placement of the shock wave generator at the farthest end of the catheter, continuously crushing proximal vascular calcified lesions through shock waves, and gradually reopening the vessel.Complete OcclusionBlood vessels.

IfJavelinIt can be achieved in the periphery, and its technical principle can also be applied to complete coronary occlusion. This is very promising in solving one of the two difficult "fortresses" in the field of heart disease—CTO, making this medical challenge easily resolvable.

Javelin

JavelinIt is a new type of shockwave catheter, which is different from traditional balloon-type shockwave catheters in that it has no balloon andThe shock wave generator is set at the distal end of the catheter, thereby achievingTransmit shock waves to the front of the catheter, and use shock waves to open occluded blood vessels.

JavelinThe catheter includes a flushing lumen, a guidewire lumen, a pressurization lumen, and a shock wave generator.

The pressurized chamber can be filled with saline to achieve the predetermined treatment pressure.
Flushing the catheter lumen allows for irrigation of the treatment area with saline solution.
The guidewire lumen is used for passing through aA 0.014" (0.36 mm) guidewire to facilitate passage through occluded vascular segments under guidewire guidance.

According to Johnson & Johnson's introduction, oneJavelinThe catheter can deliver 12 rounds of shock waves, with each round consisting of 10 shocks, totaling 120 shocks.

Currently,JavelinOnlySuitable for lithotripsy and crossing peripheral arterial calcified lesions, including iliac arteries, femoral arteries, iliofemoral arteries, popliteal arteries, and infrapopliteal arteries. FutureJavelinThe technology can also be applied to coronary arteries.

Shockwave Medical

ShockWave MedicalAs part of Johnson & Johnson's medical device division, its aim is to improveTreatment Methods for Calcified Cardiovascular Diseases.ShockWave MedicalThe goal is to establish a new standard for medical device treatment of cardiovascular calcification diseases through its differentiated and proprietary local delivery of ultrasound for the treatment of calcified plaques, which they callIntravascular Lithotripsy（“IVL”）。