Porespect Technology Completes Tens-of-Millions Pre-A+ Financing, Accelerating Solid-State Nanopore Technology Toward Industrialization

Recently, Guangzhou Porespect Technology Co., Ltd. (hereinafter referred to as "Porespect Technology") announced the completion of a Pre-A+ financing round of tens of millions of RMB, with investment from SunLand Capital. Following its previous Pre-A financing round led by Lenovo Capital, Porespect Technology has completed two consecutive financing rounds within six months. The continued recognition from capital markets and the execution of orders from listed company clients mark the company's entry into an accelerated phase in terms of foundational technology, product delivery, and industrial validation. The proceeds from this round will be primarily used for the construction of solid-state nanopore chip testing and packaging production lines, the development of detection products, and technological expansion into the advanced semiconductor sector.

Converting biological information into computable electrical signals is Porespect Technology's core definition of solid-state nanopore technology. This technology constructs nanoscale pores on thin film materials such as silicon nitride. When molecules including deoxyribonucleic acid, ribonucleic acid, and proteins are driven through the pores one by one under an electric field, the size, shape, and charge of the molecules generate picoampere-level transient perturbations to the ionic current.

Combined with high-speed acquisition and intelligent algorithms, the platform translates these "current fingerprints" into molecular identity and abundance information. Compared with detection principles that rely on complex optical, amplification, or labeling processes, solid-state nanopores enable direct measurement of the intrinsic physical properties of biological macromolecules, moving away from indirect biochemical reaction-based detection. This approach offers advantages including high sensitivity, fast speed, ease of miniaturization, compatibility with semiconductor processes, and scalability for array-based expansion.

The key to the commercialization of solid-state nanopores lies not only in "seeing signals," but also in the ability to consistently manufacture nanopores with uniform performance at stable, low cost. Porespect Technology was co-founded by doctoral graduates from Stanford University, Imperial College London, Peking University, and other leading institutions. The core team spans materials and physics, chemical analysis, semiconductor devices, molecular biology, and algorithms. The company has independently established a complete technological chain covering chip design, precision pore fabrication, microfluidic packaging, data acquisition, and signal analysis, forming high-consistency solid-state nanopore fabrication and detection capabilities that lay the foundation for the scalable application of this technology.

Based on the ability of solid-state nanopores to precisely construct, regulate, and read substances, ions, and interfaces at the nanoscale, Porespect Technology is developing a diversified application portfolio spanning "biological information reading, advanced semiconductors, and neuromorphic intelligence." Biological information reading is the core direction for the company's current productization and commercial deployment, using single-molecule current fingerprint reading of biological macromolecules including deoxyribonucleic acid, ribonucleic acid, and proteins as the entry point to serve applications in life science research, clinical diagnostics, drug discovery, public health, and industrial testing. The advanced semiconductor direction extends precision pore fabrication and micro-nano regulation capabilities toward nanoscale structure manufacturing and device integration. Looking further ahead, the company is exploring the potential value of nano-confined ion transport in fluidic memristors, neuromorphic computing, and future brain-computer interfaces. All three pathways are built upon the same foundational capability: constructing manufacturable, controllable, and readable physical interfaces at the nanoscale.

In the biological information reading direction, Porespect Technology is preparing to launch a 32-to-96-channel solid-state nanopore single-molecule analysis platform. This platform integrates array chips, multi-channel micro-current acquisition, fluidic control, and intelligent analysis software, enabling highly sensitive and rapid analysis of biological macromolecules including deoxyribonucleic acid, ribonucleic acid, and proteins under the same hardware and algorithmic architecture. Multi-channel parallel capability will drive solid-state nanopores from single-point research tools toward batch sample processing, multi-target co-detection, and automated workflows, providing a general-purpose analytical infrastructure for life science research, clinical diagnostics, and industrial testing. In areas including bloodstream infection detection, Alzheimer's disease-related biomarker detection, and rapid pathogen testing, the company is conducting collaborative research and methodological validation with leading domestic medical testing and in vitro diagnostics enterprises. At the same time, the company has secured orders from listed company clients, providing real-world demand and a delivery foundation for the market introduction of its multi-channel products.

In the advanced semiconductor direction, leveraging its capabilities in small-diameter, high-consistency, and precisely controllable pore fabrication, Porespect Technology has completed collaborative validation in areas including nanoscale precision drilling for advanced semiconductor components, micro-nano processing of dielectric thin films, and local confined structure regulation, and has secured orders from leading domestic semiconductor equipment clients. In this application scenario, solid-state nanopores serve not only as the core interface for biological molecule reading, but also as a foundational process capability for high-precision micro-nano structure manufacturing and device functional regulation, further expanding the company's industrial boundaries in advanced manufacturing.

In the brain-computer interface and neuromorphic intelligence direction, the company is exploring phenomena including tunable conductivity, state memory, and synapse-like responses exhibited by confined ion transport through solid-state nanopores, and is advancing proof-of-concept validation for fluidic memristors and neuromorphic devices. This direction remains in the early technology exploration stage, with the potential to create new technological pathways in areas including low-power neural signal preprocessing, neuromorphic computing, and foundational brain-computer interface-related devices in the future.