First Successful Clinical Application of AccuPulse® Pulsed Field Ablation System at Gaozhou People's Hospital Marks Milestone for EpiPulse Medical

On the Occasion of the Annual Academic Conference on Cardiac Pacing and Electrophysiology of the Guangdong Medical Association,At Gaozhou People's HospitalUnder the leadership of President Zhu Xiulong, Associate Chief Physician Qiu Guo and Attending Physician Feng Weiming of the Department of Cardiovascular Medicine, along with their teamAccuPulse Medical Application^®Single-Use Cardiac Pulsed Field Ablation Catheter and AccuBlator^®Cardiac Pulsed Field Ablation System Successfully Performed Cardiac Pulsed Field Ablation (PFA) Procedure on a Patient with Atrial Fibrillation.

The patient is a 70-year-old female who previously underwent pulmonary vein isolation (PVI) ablation using radiofrequency (RF) energy, followed by recurrence of paroxysmal atrial fibrillation. Based on preoperative echocardiography, which showed a left atrial diameter of 30 mm, the operator selected the AccuPulse 15–20 mm adjustable loop cardiac pulsed field ablation catheter for the procedure.

Preoperative Substrate Mapping Map

Preoperative substrate mapping revealed a distinct ablation line with no detectable potentials in the left pulmonary veins, whereas electrical activity had recovered in the right pulmonary veins. Therefore, this procedure focused on supplemental ablation targeting the right pulmonary veins. The total procedure time was only 67 minutes, including 13 minutes for modeling and mapping. Pulmonary vein isolation (PVI) using the PFA catheter was completed in just 20 minutes. A total of 35 PFA ablations were delivered, with a cumulative energy delivery time of only 6.125 seconds.

Comparison of Potentials Before and After RSPV Ablation

The operator adopted an ablation strategy of “entering the pulmonary vein with a small-diameter catheter loop and then expanding the loop diameter,” delivering radiofrequency energy only after confirming good contact force indicators. A total of four energy delivery sets (23 applications) were administered to the right superior pulmonary vein (RSPV). At each position, six ablations were performed, followed by rotation through a specified angle (e.g., 180°) and another six ablations to consolidate the lesion set and address potential gaps. Subsequently, 11 ablations were delivered slightly deeper at the pulmonary vein ostium, followed by 12 ablations at the vestibular region upon withdrawal, achieving continuous coverage from deep to superficial layers. For the right inferior pulmonary vein (RIPV), two energy delivery sets were applied, with 12 ablations performed at the vestibular region. After completion of ablation for all four pulmonary veins, electrophysiological testing and repeat substrate mapping were conducted to confirm complete pulmonary vein isolation, and the procedure was concluded successfully.

Postoperative Substrate Mapping

The operator’s team evaluation indicated that the ablation procedure proceeded smoothly throughout, with no serious adverse events occurring intraoperatively. The patient recovered well postoperatively, without any complications. AccuPulse’s adjustable circular PFA catheter achieved rapid and effective ablation within the pulmonary veins. Its contact indication function provided objective and reliable decision support for energy delivery, significantly enhancing ablation efficiency. Meanwhile, the adjustable circular catheter design flexibly accommodates variations in pulmonary vein anatomy among different patients, demonstrating excellent maneuverability and stability in complex anatomical regions. This ensured precise completion of detailed ablation, including at the pulmonary vein antrum. While ensuring procedural safety, the device fully demonstrated its clinical advantages of high efficiency, precision, and strong adaptability, providing an effective solution for interventional treatment of atrial fibrillation.

Flexible Adaptation, Precise Conformity:Its unique 7.5F adjustable loop diameter design allows for flexible adaptation to the pulmonary vein anatomy of different patients, enabling personalized fitting and significantly enhancing procedural adaptability and safety.

Intelligent Contact, Real-Time Feedback:The system is equipped with AccuPulse’s proprietary impedance-based contact force sensing technology, which enables real-time monitoring of catheter-tissue contact quality, provides clear indications of contact status, and assists operators in achieving stable and reliable catheter manipulation, thereby ensuring precise ablation.

Efficient Integration, Streamlined Processes:The circular catheter integrates mapping, modeling, and ablation functions into a single device. It enables rapid intraoperative construction of three-dimensional electroanatomic heart models and precise lesion localization, significantly reducing reliance on additional high-density mapping catheters in traditional procedures. This not only lowers procedural complexity but also reduces consumable costs, offering atrial fibrillation patients a safer, more effective, and less invasive treatment option.

Safer:7.5F Ultra-fine Catheter, Reducing Tissue Trauma

More Stable:Intelligent Contact Force Alert for Enhanced Procedural Precision

More Flexible:Adjustable loop diameter (15–20 mm or 20–25 mm) to accommodate diverse clinical preferences

AccuPulse’s approved disposable cardiac pulsed field ablation catheter overcomes the challenges of catheter contact stability and anatomical adaptability in the PFA field, providing a precise and reliable solution for pulmonary vein isolation (PVI). The AccuPulse cardiac pulsed field ablation catheter features a unique 7.5F adjustable loop diameter design, flexibly accommodating pulmonary vein ablation across diverse anatomical structures. Its intelligent contact feedback and flexible electrode selection empower operators with full control, enabling precise pulsed field ablation!

AccuPulse is an innovative company dedicated to the research, development, and commercialization of cutting-edge technologies in the field of cardiac electrophysiology. Backed by a core team with profound expertise in electrophysiology and extensive experience in the industrialization of medical devices, AccuPulse is committed to providing safer, more efficient, and more convenient treatment options for patients with arrhythmias, such as atrial fibrillation.

AccuPulse^®Disposable Cardiac Pulsed Field Ablation Catheter and AccuBlator^®The successful application of the cardiac pulsed field ablation system at Gaozhou People's Hospital marks a milestone achievement for AccuPulse in the field of innovative electrophysiological therapy.

Chief Physician of Cardiology, President of Gaozhou People's Hospital; Postdoctoral Cooperative Supervisor at Southern Medical University; External Industry (Enterprise) Mentor for Doctoral Candidates in Biology and Pharmaceutical Engineering at Sun Yat-sen University; Master’s Supervisor in Cardiology at Guangdong Medical University; Council Member of the Guangdong Medical Association; Vice Chairman of the Quality Control Branch for Cardiovascular Diseases under the Guangdong Hospital Association; Vice Chairman of the Cardiac Pacing and Electrophysiology Physicians Branch under the Guangdong Medical Doctor Association; Vice Chairman of the Pacing and Electrophysiology Physicians Branch under the Guangdong Interventional Cardiology Association; First Vice Chairman of the Precision Medicine Branch of the Guangdong Medical Association; Executive Director of the 7th Chinese Hypertension League; Vice Chairman of the County-Level Branch of the Guangdong Hospital Association; Vice Chairman of the Cardiology Branch of the Maoming Medical Association; Standing Committee Member of the Guangdong Health Education Management Committee; Committee Member of the Cardiovascular Management Professional Committee under the Guangdong Medical Industry Association; Chairperson of the China Democratic Progressive Party (CDP) Gaozhou Municipal Committee.Expertise lies in the interventional diagnosis and treatment of coronary heart disease and arrhythmias. Holds national certifications from the Ministry of Health in three areas: cardiac pacing, radiofrequency ablation for electrophysiology, and coronary intervention. Participated in two projects under the National Ministry of Science and Technology’s “12th Five-Year Plan” and received one Guangdong Provincial Scientific and Technological Achievement Promotion Award. Published 25 papers in provincial and national journals and 4 SCI-indexed articles, with a highest impact factor of 14.5. Authored one monograph as the primary author.

Associate Chief Physician, Member of the Young Committee of Guangdong Electrophysiology Society, previously trained in electrophysiology at Guangdong Provincial People's Hospital, proficient in performing various catheter ablation procedures for arrhythmias and pacemaker implantation.

Commenced clinical practice in cardiology in 2015, and completed advanced training in cardiac pacing and electrophysiology procedures at the First Affiliated Hospital of Sun Yat-sen University; Member of the Pharmacotherapy Group of the 5th Committee of the Cardiac Pacing and Electrophysiology Branch of the Guangdong Medical Association; Member of the 1st Young Professionals Committee of the Cardiovascular Medicine Branch of the Maoming Medical Association; Committee Member of the 3rd Committee of the Cardiac Pacing and Electrophysiology Professional Physicians Branch of the Guangdong Medical Doctor Association.