Nantong University Affiliated Hospital Successfully Completes First Clinical Application of Ablation Technologies’ Adjustable Circular PFA System

Recently,Affiliated Hospital of Nantong UniversityAs one of the first clinical application units in China,By Professor Lu Qi, Director of the Department of Cardiology, and his teamApplication of AccuPulse Medical^®Disposable Cardiac Pulsed Field Ablation Catheter and AccuBlator^®Cardiac Pulsed Field Ablation System Successfully Performed Cardiac Pulsed Field Ablation (PFA) Procedure on a Patient with Atrial Fibrillation.

The patient is a 61-year-old male. Preoperative examination revealed an anteroposterior diameter of the left atrium of 47 mm. Intraoperative modeling using the HD Grid catheter indicated enlarged pulmonary veins. The operator employed the AccuPulse Medical 15–20 mm adjustable-loop cardiac pulsed field ablation catheter. The procedure focused on pulmonary vein isolation (PVI). To ensure the quality of PVI and reduce the risk of recurrence, additional ablation pulses were appropriately delivered to the regions with enlarged pulmonary veins, thereby enhancing the continuity of ablative lesions and ensuring effective isolation.

PVI Ablation Map

The total procedure time was 97 minutes, with only 9 minutes required from venous puncture to transseptal puncture for establishing left atrial access. Mapping and modeling took 15 minutes, and pulmonary vein ablation lasted 60 minutes, delivering a total of 216 ablation lesions. Intraoperatively, circumferential pulmonary vein isolation was performed on the left superior and right inferior pulmonary veins, among others, with an additional 12 supplemental ablations applied to the anterior-superior aspect of the right-sided veins. Following ablation, substrate mapping was conducted using the catheter, and bidirectional pulmonary vein block was verified under pharmacological provocation. After confirming the efficacy of the ablation, the catheter was withdrawn, and the procedure was completed successfully.

Pre- and Post-operative Substrate Mapping

The operator fully affirmed the clinical performance of the catheter. The loop-adjustment function operated normally, with a stable and controllable circular configuration that rapidly adapted to the pulmonary vein antrum across varying anatomical structures. The overall manipulation process was smooth, and contact-force feedback was clear and sensitive, enabling the operator to accurately assess the degree of catheter-myocardial tissue contact and effectively ensure ablation efficacy. The impedance monitoring function was reliable, with stable real-time data providing robust support for the safety and effectiveness of energy delivery. In summary, the catheter features a rational design and reliable performance, meeting the requirements for circumferential pulmonary vein isolation under various complex anatomical conditions, including enlarged pulmonary veins, thereby providing strong assurance for the precise implementation of pulsed field ablation.

Flexible Adaptation, Precise Conformity:Its unique 7.5F adjustable loop diameter design allows for flexible adaptation to the pulmonary vein anatomy of different patients, enabling personalized fitting and significantly enhancing procedural adaptability and safety.

Intelligent Contact, Real-Time Feedback:The system is equipped with AccuPulse’s proprietary impedance-based contact force sensing technology, which enables real-time monitoring of catheter-tissue contact quality, provides clear indications of contact status, and assists operators in achieving stable and reliable catheter manipulation, thereby ensuring a solid foundation for precise ablation.

Efficient Integration, Streamlined Processes:The circular catheter integrates mapping, modeling, and ablation functions into a single device. It enables rapid intraoperative construction of three-dimensional electroanatomical models of the heart and precise lesion localization, significantly reducing reliance on additional high-density mapping catheters in conventional procedures. This approach not only lowers procedural complexity but also reduces consumable costs, offering atrial fibrillation patients a safer, more effective, and less invasive treatment option.

Safer:7.5F Ultra-Fine Catheter, Reducing Tissue Trauma

More Stable:Smart Contact Force Guidance for More Precise Procedures

More Flexible:Adjustable loop diameter (15–20 mm or 20–25 mm) to accommodate diverse clinical choices

AccuPulse Medical’s approved single-use cardiac pulsed field ablation catheter overcomes the challenges of catheter contact stability and anatomical adaptability in the PFA field, providing a precise and reliable solution for pulmonary vein isolation (PVI). The AccuPulse cardiac pulsed field ablation catheter features a unique 7.5F adjustable loop diameter design, flexibly accommodating pulmonary vein ablation across diverse anatomical structures. Its intelligent contact feedback and flexible electrode selection empower operators with superior control, enabling precise pulsed field ablation!

AccuPulse Medical is an innovative enterprise dedicated to the research, development, and commercialization of cutting-edge technologies in the field of cardiac electrophysiology. Backed by a core team with profound expertise in electrophysiology and extensive experience in the industrialization of medical devices, the company is committed to providing safer, more efficient, and more convenient treatment options for patients with arrhythmias, such as atrial fibrillation.

This AccuPulse^®Disposable Cardiac Pulsed Field Ablation Catheter and AccuBlator^®The successful application of the cardiac pulsed field ablation system at the Affiliated Hospital of Nantong University marks a milestone achievement for AccuPulse in the field of innovative electrophysiological therapy technologies.

Ph.D., Professor. Director of the Cardiovascular Intensive Care Unit and Director of the Arrhythmia Center at the Affiliated Hospital of Nantong University. Proficient in the implantation of complex pacemakers (ICD, CRT, LBBP, Micra), catheter ablation for complex arrhythmias (atrial fibrillation, atrial flutter, ventricular arrhythmias), left atrial appendage closure, and ablation for hypertrophic obstructive cardiomyopathy.Academic Appointments: Member of the Catheter Ablation Professional Group under the National Medical Quality Control Center for Arrhythmia Intervention Technology; Member of the Heart Rhythm Committee of the Chinese Medical Doctor Association; Standing Committee Member of the Geriatric Cardiovascular Disease Branch of the China Research Hospital Association for Geriatric Health Care; Member of the Young and Middle-aged Electrophysiology Working Committee of the Chinese Society of Cardiac Electrophysiology and Pacing and the Heart Rhythm Committee of the Chinese Medical Doctor Association; Standing Committee Member of the Arrhythmia Prevention and Treatment Professional Committee of the National Pharmaceutical Technology Market Association; Member of the Translational Medicine Branch of the Chinese Research Hospital Association; Vice Chairman of the Jiangsu Provincial Society of Cardiac Electrophysiology and Pacing; Vice Chairman of the Cardiogenic Stroke Prevention and Treatment Committee of the Jiangsu Stroke Society; Vice Chairman of the Cardiovascular Disease Branch of the Jiangsu Geriatric Medical Association; Member of the Cardiovascular Disease Branch of the Jiangsu Medical Association; Member of the Heart Rhythm Committee of the Jiangsu Medical Doctor Association; Member of the Heart Failure Committee of the Jiangsu Medical Doctor Association; Chairman of the Cardiac Electrophysiology and Pacing Branch of the Nantong Medical Association; Chairman of the Heart Rhythm Physicians Branch of the Nantong Medical Doctor Association; Vice Chairman of the Cardiovascular Disease Branch of the Nantong Medical Association; Executive Director of the Atrial Fibrillation and Heart Failure Center at the Affiliated Hospital of Nantong University.Academic Achievements: Recipient of First and Second Prizes for the Introduction of New Medical Technologies in Jiangsu Province; authored more than 50 academic papers. Recognized as a High-Level Talent under the Provincial "Six Major Talent Peaks" Program and as a Young and Middle-aged Scientific and Technological Leader under the Municipal "226 Project." Proposed novel concepts for sequential precision treatment and management of refractory heart failure, as well as sequential precision cryoablation therapy for long-standing persistent atrial fibrillation.