DyWin Biosciences Upgrades Next-Gen Nucleic Acid Synthesis Chip to Gb-Scale, Enabling Ultra-High-Throughput Applications Including HD Video DNA Data Storage

Recently, Dynasty Gene announced the successful upgrade of its next-generation nucleic acid synthesis chip, increasing the synthesis throughput to the gigabase (Gb) level per chip. This breakthrough overcomes the limitations of existing technologies and opens up new possibilities for ultra-high-throughput application scenarios such as AI-driven biopharmaceuticals and data storage.

As a pioneer of next-generation nucleic acid synthesis in China, Dynasty Gene has successfully commercialized its DYHOW new-generation ultra-high-throughput DNA synthesis platform. This platform is based on a proprietary virtual-wall quartz chip synthesis process, achieving high-precision repetitive superposition of ultramicro droplets at the micrometer scale and stable, reliable microfluidic control, thereby enabling true ultra-high-throughput, high-quality in situ oligonucleotide synthesis. Recently, Dynasty Gene upgraded the manufacturing process of its next-generation nucleic acid synthesis chips to the second generation. The latest DYHOW 2.0 platform significantly increases synthesis density per unit area. While maintaining unchanged costs, it boosts the overall throughput—i.e., the number of personalized sequences synthesized simultaneously in a single run—from 1.5 million to 4.35 million, with the total number of bases synthesized per run successfully reaching the gigabase (Gb) level.

Nucleic acid synthesis is a critical enabling technology that underpins life sciences and applied research. Driven by demands from fields such as biopharmaceuticals, genomics, and synthetic biology, ultra-high-throughput nucleic acid synthesis, in particular, holds extensive application value and numerous potential use cases. Currently, the throughput of ultra-high-throughput nucleic acid synthesis has reached the level of millions to tens of millions of bases. This scale largely meets the needs of conventional basic and applied research. However, for applications requiring higher DNA throughput at lower costs—such as AI-driven biopharmaceuticals and DNA data storage—existing throughput remains a bottleneck. Breakthroughs in gigabase-level synthesis throughput have enhanced the efficiency of ultra-high-throughput DNA synthesis and further reduced costs, providing robust foundational tool support for the development of these applications.

The most notable advancement is DNA data storage technology. This novel approach encodes information using the nucleotide sequences of DNA. Compared with conventional hard disk drive (HDD) storage, DNA-based storage offers unparalleled advantages: its storage density is one million times greater than that of conventional media, with each gram of DNA capable of storing up to 215 petabytes (PB) of data—equivalent to the capacity of 220,000 1-terabyte (TB) hard drives. This provides a new paradigm for addressing the exponentially growing demand for data storage. When stored under appropriate conditions, DNA can remain stable for hundreds of thousands of years, making it highly valuable for the ultra-long-term archival of critical cold data.

Dynasty Gene also demonstrated a test of high-definition video storage using high-throughput DNA synthesized on the DYHOW 2.0 platform. Researchers employed a mature codec system to store a 9.6 MB high-definition video showcasing urban roads into DNA, and after sequencing and decoding, successfully retrieved the source video file information with 100% fidelity.